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dc.contributor.authorBenito-León, Julián
dc.contributor.authorLouis, Elan D.
dc.contributor.authorRomero Muñoz, Juan Pablo 
dc.contributor.authorHernández-Tamames, Juan Antonio
dc.contributor.authorManzanedo, Eva
dc.contributor.authorÁlvarez-Linera, Juan
dc.contributor.authorBermejo Pareja, Félix
dc.contributor.authorPosada, Ignacio
dc.contributor.authorRocon, Eduardo
dc.description.abstractEssential tremor (ET) has been associated with a spectrum of clinical features, with both motor and nonmotor elements, including cognitive deficits. We employed resting-state functional magnetic resonance imaging (fMRI) to assess whether brain networks that might be involved in the pathogenesis of nonmotor manifestations associated with ET are altered, and the relationship between abnormal connectivity and ET severity and neuropsychological function. Resting-state fMRI data in 23 ET patients (12 women and 11 men) and 22 healthy controls (HC) (12 women and 10 men) were analyzed using independent component analysis, in combination with a ‘‘dualregression’’ technique, to identify the group differences of resting-state networks (RSNs) (default mode network [DMN] and executive, frontoparietal, sensorimotor, cerebellar, auditory/language, and visual networks). All participants underwent a neuropsychological and neuroimaging session, where resting-state data were collected. Relative to HC, ET patients showed increased connectivity in RSNs involved in cognitive processes (DMN and frontoparietal networks) and decreased connectivity in the cerebellum and visual networks. Changes in network integrity were associated not only with ET severity (DMN) and ET duration (DMN and left frontoparietal network), but also with cognitive ability.Moreover, in at least 3 networks (DMN and frontoparietal networks), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, verbal memory, visual memory, and language) and depressive symptoms. Further, in the visual network, decreased connectivity was associated with worse performance on visuospatial ability. ET was associated with abnormal brain connectivity in major RSNs that might be involved in both motor and nonmotor symptoms. Our findings underscore the importance of examining RSNs in this population as a biomarker of
dc.publisherMedicine, Vol. 94, Nº 49spa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectEssential tremorspa
dc.titleAltered Functional Connectivity in Essential Tremor. A Resting-State fMRI
dc.description.extent626 KBspa

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