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dc.contributor.authorDomínguez, Fernando
dc.contributor.authorCliment, Vicente
dc.contributor.authorZorio, Esther
dc.contributor.authorRipoll Vera, Tomás
dc.contributor.authorSalazar Mendiguchía, Joel
dc.contributor.authorGarcía Pinilla, José Manuel
dc.contributor.authorUrbano Moral, José Ángel
dc.contributor.authorFernández Fernández, Xusto
dc.contributor.authorLópez Cuenca, David
dc.contributor.authorAjo Ferrer, Raquel
dc.contributor.authorSanz Sánchez, Jorge
dc.contributor.authorGómez Pérez, Yolanda
dc.contributor.authorLópez Garrido, Miguel A.
dc.contributor.authorBarriales Villa, Roberto
dc.contributor.authorGimeno, Juan Ramón
dc.contributor.authorGarcía Pavía, Pablo
dc.description.abstractBackground: Chronic anticoagulation with vitamin K antagonists (VKAs) is recommended in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF). Direct oral anticoagulants (NOACs) are an alternative to VKAs but there are limited data to support their use in HCM. We sought to describe the pattern of use, thromboembolic events, bleeding and quality of life in patients with HCM and AF treated with NOACs. Methods: Data from patients treated with NOACs (n=99) and VKA (n=433) at 9 inherited cardiac diseases units were retrospectively collected. Annual rates of embolic events, serious bleeding and death were analysed and compared. Quality of life and treatment satisfaction were evaluated with SF-36 and SAFUCA questionnaires in 80 NOAC-treated and 57 VKA-treated patients. Results: After median follow-up of 63 months (IQR:26–109), thromboembolic events (TIA/stroke and peripheral embolism) occurred in 10% of patients on oral anticoagulation. Major/clinically relevant bleeding occurred in 3.8% and the global mortality rate was 23.3%. Thromboembolic event rate was 0.62 per 100 patient-years in the NOAC group vs. 1.59 in the VKA group [subhazard ratio (SHR) 0.32;95%CI:0.04– 2.45;p=0.27]. Major/clinically relevant bleeding occurred in 0.62 per 100 person-years in the NOAC group vs. 0.60 in the VKA group (SHR 1.28;95%CI 0.18–9.30;p=0.85). Quality of life scores were similar in both groups; however, NOAC-treated patients achieved higher scores in the SAFUCA. Conclusions: HCM patients with AF on NOACs showed similar embolic and bleeding rates to those on VKA. Although quality of life was similar in both groups, the NOAC group reported higher treatment
dc.publisherInternational Journal of Cardiologyspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectHypertrophic cardiomyopathyspa
dc.subjectAtrial fibrillationspa
dc.titleDirect oral anticoagulants in patients with hypertrophic cardiomyopathy and atrial
dc.description.extent929 KBspa

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España