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dc.contributor.authorMademont Sole, Irene
dc.contributor.authorMates, Jesús
dc.contributor.authorFernández Ávila, Ana Isabel
dc.contributor.authorYotti, Raquel
dc.contributor.authorEspinosa, Mª Ángeles
dc.contributor.authorPérez Serra, Alexandra
dc.contributor.authorColl, Mónica
dc.contributor.authorMéndez, Irene
dc.contributor.authorIglesias, Anna
dc.contributor.authorDel Olmo, Bernat
dc.contributor.authorRiuró, Helena
dc.contributor.authorCuenca, Sofía
dc.contributor.authorAllegue, Catarina
dc.contributor.authorCampuzano, Óscar
dc.contributor.authorPicó, Ferrán
dc.contributor.authorFerrer Costa, Carles
dc.contributor.authorÁlvarez, Patricia
dc.contributor.authorCastillo, Sergio
dc.contributor.authorGarcía Pavía, Pablo 
dc.contributor.authorGonzález López, Esther
dc.contributor.authorPadrón Barthe, Laura
dc.contributor.authorDíaz de Bustamante, Aránzazu
dc.contributor.authorDarnaude, María Teresa
dc.contributor.authorGonzález Hevia, José Ignacio
dc.contributor.authorBrugada, Josep
dc.contributor.authorFernández Avilés, Francisco
dc.contributor.authorBrugada, Ramón
dc.description.abstractHypertrophic cardiomyopathy (HCM) is the most prevalent inherited heart disease. Three hundred and eighty-seven consecutive unrelated patients with HCM were screened for genetic variants in the 5 most frequent genes (MYBPC3, MYH7, TNNT2, TNNI3 and TPM1) using Sanger sequencing (N = 84) or NGS (N = 303). In the NGS cohort we analyzed 20 additional minor or candidate genes, and applied a proprietary bioinformatics algorithm for detecting CNVs. Additionally, the rate and classification of TTN variants in HCM were compared with 427 patients without structural heart disease. A small percentage of HCM cases without point mutations in the 5 main genes are explained by P/LP variants in minor or candidate genes and CNVs. Screening for variants in TTN in HCM patients drastically increases the number of inconclusive tests, and shows a rate of VUS that is similar to patients without structural heart disease, suggesting that this gene should not be analyzed for clinical purposes in HCM. Nextgeneration sequencing (NGS) is the preferred genetic test, but the diagnostic value of screening for minor and candidate genes, and the role of copy number variants (CNVs) deserves further evaluationeng
dc.publisherPlos Onespa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectHypertrophic cardiomyopathyspa
dc.titleAdditional value of screening for minor genes and copy number variants in hypertrophic
dc.description.extent5958 KBspa

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