dc.contributor.author | Calvo Sánchez, María Inmaculada | |
dc.contributor.author | Fernández Martos, Sandra | |
dc.contributor.author | Carrasco, Elisa | |
dc.contributor.author | Moreno Bueno, Gema | |
dc.contributor.author | Bernabéu, Carmelo | |
dc.contributor.author | Quintanilla, Miguel | |
dc.contributor.author | Espada, Jesús | |
dc.date.accessioned | 2019-04-08T11:06:56Z | |
dc.date.available | 2019-04-08T11:06:56Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1674-2788 | spa |
dc.identifier.uri | http://hdl.handle.net/10641/1600 | |
dc.description.abstract | The hair follicle is a biological oscillator that alternates growth, regression, and rest phases driven by the sequential activation
of the proliferation/differentiation programs of resident stem cell populations. The activation of hair follicle stem cell niches and
subsequent entry into the growing phase is mainly regulated by Wnt/β-catenin signalling, while regression and resting phases
are mainly regulated by Tgf-β/Bmp/Smad activity. A major question still unresolved is the nature of the molecular switch that
dictates the coordinated transition between both signalling pathways. Here we have focused on the role of Endoglin (Eng), a key
co-receptor for members of the Tgf-β/Bmp family of growth factors. Using an Eng haploinsufficient mouse model, we report that
Eng is required to maintain a correct follicle cycling pattern and for an adequate stimulation of hair follicle stem cell niches. We
further report that β-catenin binds to the Eng promoter depending on Bmp signalling. Moreover, we show that β-catenin interacts
with Smad4 in a Bmp/Eng-dependent context and both proteins act synergistically to activate Eng promoter transcription. These
observations point to the existence of a growth/rest switching mechanism in the hair follicle that is based on an Eng-dependent
feedback cross-talk between Wnt/β-catenin and Bmp/Smad signals. | spa |
dc.language.iso | eng | spa |
dc.publisher | Journal of Molecular Cell Biology | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Endoglin | spa |
dc.subject | Hair follicle | spa |
dc.subject | Skin stem cells | spa |
dc.subject | Wnt/β-catenin | spa |
dc.subject | Tgf-β/Bmp/Smad | spa |
dc.title | A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | SMUR | spa |
dc.rights.accessRights | open access | spa |
dc.description.extent | 1347 KB | spa |
dc.identifier.doi | 10.1093/jmcb/mjy051 | spa |