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dc.contributor.authorCalvo Sánchez, María Inmaculada
dc.contributor.authorFernández Martos, Sandra
dc.contributor.authorCarrasco, Elisa
dc.contributor.authorMoreno Bueno, Gema
dc.contributor.authorBernabéu, Carmelo
dc.contributor.authorQuintanilla, Miguel
dc.contributor.authorEspada, Jesús
dc.date.accessioned2019-04-08T11:06:56Z
dc.date.available2019-04-08T11:06:56Z
dc.date.issued2018
dc.identifier.issn1674-2788spa
dc.identifier.urihttp://hdl.handle.net/10641/1600
dc.description.abstractThe hair follicle is a biological oscillator that alternates growth, regression, and rest phases driven by the sequential activation of the proliferation/differentiation programs of resident stem cell populations. The activation of hair follicle stem cell niches and subsequent entry into the growing phase is mainly regulated by Wnt/β-catenin signalling, while regression and resting phases are mainly regulated by Tgf-β/Bmp/Smad activity. A major question still unresolved is the nature of the molecular switch that dictates the coordinated transition between both signalling pathways. Here we have focused on the role of Endoglin (Eng), a key co-receptor for members of the Tgf-β/Bmp family of growth factors. Using an Eng haploinsufficient mouse model, we report that Eng is required to maintain a correct follicle cycling pattern and for an adequate stimulation of hair follicle stem cell niches. We further report that β-catenin binds to the Eng promoter depending on Bmp signalling. Moreover, we show that β-catenin interacts with Smad4 in a Bmp/Eng-dependent context and both proteins act synergistically to activate Eng promoter transcription. These observations point to the existence of a growth/rest switching mechanism in the hair follicle that is based on an Eng-dependent feedback cross-talk between Wnt/β-catenin and Bmp/Smad signals.spa
dc.language.isoengspa
dc.publisherJournal of Molecular Cell Biologyspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectEndoglinspa
dc.subjectHair folliclespa
dc.subjectSkin stem cellsspa
dc.subjectWnt/β-cateninspa
dc.subjectTgf-β/Bmp/Smadspa
dc.titleA role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle.spa
dc.typearticlespa
dc.description.versionpre-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent1347 KBspa
dc.identifier.doi10.1093/jmcb/mjy051spa


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