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dc.contributor.authorCalvo Sánchez, María Inmaculada
dc.contributor.authorFernández Martos, Sandra
dc.contributor.authorMontoya, Juan José
dc.contributor.authorEspada, Jesús
dc.date.accessioned2019-04-09T11:21:25Z
dc.date.available2019-04-09T11:21:25Z
dc.date.issued2019
dc.identifier.issn2045-2322spa
dc.identifier.urihttp://hdl.handle.net/10641/1616
dc.description.abstractThe emerging variety of signalling roles for ROS in eukaryotic cells and tissues is currently a matter of intense research. Here we make use of ex vivo cultured single human hair follicles as an experimental model to demonstrate that a transient production of non-lethal endogenous ROS levels in these mini-organs promotes efficiently the entry into the growth phase (anagen). The stimulatory process implicates the specific activation of the hair follicle stem cell niche, encompassing the induction of stem cell differentiation markers (Ck15), overall cell proliferation and sustained growth of the tissue associated with expression of gen targets (Ccnd1) concomitant with the inhibition of Wnt signaling antagonists and repressors (Dkk1, Gsk3β) of Wnt signaling. As a whole, this observation indicates that, once activated, ROS signalling is an intrinsic mechanism regulating the hair follicle stem cell niche independently of any external signal.spa
dc.language.isoengspa
dc.publisherScientific reportsspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleIntrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent1740 KBspa
dc.identifier.doi10.1038/s41598-019-39992-8spa


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España