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dc.contributor.authorZaragoza Sánchez, Carlos 
dc.contributor.authorSaura, Marta
dc.contributor.authorHernández, Ignacio
dc.contributor.authorRamírez Carracedo, Rafael
dc.contributor.authorGarcía García, Francisco
dc.contributor.authorZamorano, José L.
dc.contributor.authorMangas, Alipio
dc.contributor.authorToro, Rocío
dc.date.accessioned2019-04-09T12:01:21Z
dc.date.available2019-04-09T12:01:21Z
dc.date.issued2019
dc.identifier.issn0144-8463spa
dc.identifier.urihttp://hdl.handle.net/10641/1619
dc.description.abstractA new familial dilated cardiomyopathy (FDCM) was found related to mutations in BAG3 gene. MicroRNAs (miRNAs) represent new targets of FDCM, although no studies have assessed clinical association between Bcl2-associated athanogene 3 (BAG3)-related DCM and miRNAs. Here, we studied whether a clinical association between BAG3-related FDCM and circulating miRNAs may have diagnostic and prognostic value in a small cohort of familial related individuals carrying a BAG3 mutation (BAG3+) and/or diagnosed of dilated cardiomyopathy (DCM) (DCM+). The analysis of 1759 circulating miRNAs showed significant differences between BAG3+ and BAG3- individuals for miRNAs mir-3191-3p, 6769b-3p, 1249-ep, 154-5p, 6855-5p, and 182-5p, while comparisons between BAG3+/DCM+ versus BAG3+/DCM- were restricted to miRNAs mir-154-5p, 6885-5p, and 182-5p, showing significant correlation with systolic and diastolic blood pressure, A wave, left atrium length, and left atrium area. Additionally, when stratified by gender and age, miRNAs were statistically correlated with critical parameters, including left ventricle ejection fraction (LVEF) and ventricular diameter, in women and young men. Likewise, 56% of BAG3+/DCM+, significantly co-expressed mir-154-5p and mir-182-5p, and a slight 4% did not express such combination, suggesting that co-expression of mir-154-5p and mir-182-5p may potentially show diagnostic value. Further studies will require long-term follow-up, and validation in larger populations.spa
dc.language.isoengspa
dc.publisherBioscience Reportsspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleDifferential expression of circulating miRNAs as a novel tool to assess BAG3-associated familial dilated cardiomyopathy.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent729 KBspa
dc.identifier.doi10.1042/BSR20180934spa


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