Show simple item record

dc.contributor.authorFernández Martos, Sandra
dc.contributor.authorCalvo Sánchez, María Inmaculada
dc.contributor.authorGarcía Alonso, Karla
dc.contributor.authorCastro, Begoña
dc.contributor.authorHashtroody, Bita
dc.contributor.authorEspada, Jesús
dc.date.accessioned2019-04-22T11:14:21Z
dc.date.available2019-04-22T11:14:21Z
dc.date.issued2019
dc.identifier.issn1661-6596spa
dc.identifier.urihttp://hdl.handle.net/10641/1624
dc.description.abstractGlycosaminoglycans (GAGs) and associated proteoglycans have important functions in homeostatic maintenance and regenerative processes (e.g., wound repair) of the skin. However, little is known about the role of these molecules in the regulation of the hair follicle cycle. Here we report that growing human hair follicles ex vivo in a defined GAG hydrogel mimicking the dermal matrix strongly promotes sustained cell survival and maintenance of a highly proliferative phenotype in the hair bulb and suprabulbar regions. This significant effect is associated with the activation of WNT/β-catenin signaling targets (CCDN1, AXIN2) and with the expression of stem cell markers (CK15, CD34) and growth factors implicated in the telogen/anagen transition (TGFβ2, FGF10). As a whole, these results point to the dermal GAG matrix as an important component in the regulation of the human hair follicle growth cycle, and to GAG-based hydrogels as potentially relevant modulators of this process both in vitro and in vivo.spa
dc.language.isoengspa
dc.publisherInternational Journal of Molecular Sciencesspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectGlycosaminoglycansspa
dc.subjectHyaluronic acidspa
dc.subjectStem cellsspa
dc.subjectHuman hair folliclspa
dc.titleSustained Human Hair Follicle Growth Ex Vivo in a Glycosaminoglycan Hydrogel Matrix.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent4320 KBspa
dc.identifier.doi10.3390/ijms20071741spa


Files in this item

FilesSizeFormatView
ijms-20-01741.pdf4.218MbPDFView/Open

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España