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dc.contributor.authorFernández Martos, Sandra
dc.contributor.authorCalvo Sánchez, María Inmaculada
dc.contributor.authorGarcía Alonso, Karla
dc.contributor.authorCastro, Begoña
dc.contributor.authorHashtroody, Bita
dc.contributor.authorEspada, Jesús
dc.description.abstractGlycosaminoglycans (GAGs) and associated proteoglycans have important functions in homeostatic maintenance and regenerative processes (e.g., wound repair) of the skin. However, little is known about the role of these molecules in the regulation of the hair follicle cycle. Here we report that growing human hair follicles ex vivo in a defined GAG hydrogel mimicking the dermal matrix strongly promotes sustained cell survival and maintenance of a highly proliferative phenotype in the hair bulb and suprabulbar regions. This significant effect is associated with the activation of WNT/β-catenin signaling targets (CCDN1, AXIN2) and with the expression of stem cell markers (CK15, CD34) and growth factors implicated in the telogen/anagen transition (TGFβ2, FGF10). As a whole, these results point to the dermal GAG matrix as an important component in the regulation of the human hair follicle growth cycle, and to GAG-based hydrogels as potentially relevant modulators of this process both in vitro and in
dc.publisherInternational Journal of Molecular Sciencesspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectHyaluronic acidspa
dc.subjectStem cellsspa
dc.subjectHuman hair folliclspa
dc.titleSustained Human Hair Follicle Growth Ex Vivo in a Glycosaminoglycan Hydrogel
dc.description.extent4320 KBspa

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España