Show simple item record

dc.contributor.authorNavarrete, Marta
dc.contributor.authorCuartero, María I.
dc.contributor.authorPalenzuela Muñoz, Rocío 
dc.contributor.authorDraffin, Jonathan E.
dc.contributor.authorKonomi, Ainoa
dc.contributor.authorSerra, Irene
dc.contributor.authorColié, Sandra
dc.contributor.authorCastaño Castaño, Sergio
dc.contributor.authorHasan, Mazahir T.
dc.contributor.authorNebreda, Ángel R.
dc.contributor.authorEsteban, José A.
dc.date.accessioned2019-07-31T07:57:18Z
dc.date.available2019-07-31T07:57:18Z
dc.date.issued2019
dc.identifier.issn2041-1723spa
dc.identifier.urihttp://hdl.handle.net/10641/1669
dc.description.abstractNMDA receptor-dependent long-term depression (LTD) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. The core mechanism for this form of plasticity is thought to be entirely neuronal. However, we now demonstrate that astrocytic activity drives LTD at CA3-CA1 synapses. We have found that LTD induction enhances astrocyte-to-neuron communication mediated by glutamate, and that Ca2+ signaling and SNARE-dependent vesicular release from the astrocyte are required for LTD expression. In addition, using optogenetic techniques, we show that low-frequency astrocytic activation, in the absence of presynaptic activity, is sufficient to induce postsynaptic AMPA receptor removal and LTD expression. Using cell-type-specific gene deletion, we show that astrocytic p38α MAPK is required for the increased astrocytic glutamate release and astrocyte-to-neuron communication during low-frequency stimulation. Accordingly, removal of astrocytic (but not neuronal) p38α abolishes LTD expression. Finally, this mechanism modulates long-term memory in vivo.spa
dc.language.isoengspa
dc.publisherNature Communicationsspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleAstrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent5316 KBspa
dc.identifier.doi10.1038/s41467-019-10830-9spa


Files in this item

FilesSizeFormatView
Navarrete_et_al-2019-Nature_Co ...5.191MbPDFView/Open

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España