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dc.contributor.authorMontalvo Quiros, Sandra
dc.contributor.authorLuque García, José L.
dc.date.accessioned2019-09-05T11:36:51Z
dc.date.available2019-09-05T11:36:51Z
dc.date.issued2019
dc.identifier.issn0278-6915spa
dc.identifier.urihttp://hdl.handle.net/10641/1670
dc.description.abstractTitanium dioxide nanoparticles (TiO2-NPs) are being used in several consumer products. The high refractive index of nano-scaled titanium dioxide particles allows them to protect from UV radiation, and so, they can be found as one of the main components of cosmetics and suncreens. Many studies have reported the potential toxicological effects associated to TiO2-NPs such as ROS generation, DNA damage, apoptosis and cell cycle arrest, among others. The continuous and systematic use of TiO2-NPs in cosmetic products requires a full comprehension of the risks involving their sustained contact with the human skin. Thus, it is important to evaluate not only the hazardous effects but to elucidate the biomolecular mechanisms involved in such effects. Based on this premises, we have evaluated the potential toxicity of TiO2-NPs using a human epithelial cell culture (HaCaT cells) as in-vitro model, together with different bioanalytical approaches and mass spectrometrybased quantitative proteomics, to gain a deeper insight into the molecular mechanisms of toxicity associated to TiO2-NPs exposurespa
dc.language.isoengspa
dc.publisherFood and Chemical Toxicologyspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectTiO2 nanoparticlesspa
dc.subjectToxicity mechanismsspa
dc.subjectQuantitative proteomicsspa
dc.titleCombination of bioanalytical approaches and quantitative proteomics for the elucidation of the toxicity mechanisms associated to TiO2 nanoparticles exposure in human keratinocytes.spa
dc.typearticlespa
dc.description.versionpre-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent451 KBspa
dc.identifier.doi10.1016/j.fct.2019.03.036


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España