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dc.contributor.authorMoncho Amor, Verónica
dc.contributor.authorPintado Berninches, Laura
dc.contributor.authorIbáñez de Cáceres, Inmaculada
dc.contributor.authorMartín Villar, Ester
dc.contributor.authorQuintanilla, Miguel
dc.contributor.authorChakravarty, Probir
dc.contributor.authorCortes Sempere, María
dc.contributor.authorFernández Varas, Beatriz
dc.contributor.authorRodríguez Antolín, Carlos
dc.contributor.authorDe Castro, Javier
dc.contributor.authorSastre, Leandro
dc.contributor.authorPerona, Rosario
dc.date.accessioned2019-09-09T08:15:51Z
dc.date.available2019-09-09T08:15:51Z
dc.date.issued2019
dc.identifier.issn1661-6596spa
dc.identifier.urihttp://hdl.handle.net/10641/1672
dc.description.abstractDUSP6/MKP3 is a dual-specific phosphatase that regulates extracellular regulated kinase ERK1/2 and ERK5 activity, with an increasingly recognized role as tumor suppressor. In silico studies from Gene expression Omnibus (GEO) and Cancer Genome atlas (TCGA) databases reveal poor prognosis in those Non-small cell lung cancer (NSCLC) patients with low expression levels of DUSP6. In agreement with these data, here we show that DUSP6 plays a major role in the regulation of cell migration, motility and tumor growth. We have found upregulation in the expression of several genes involved in epithelial to mesenchymal transition (EMT) in NSCLC-DUSP6 depleted cells. Data obtained in RNA-seq studies carried out in DUSP6 depleted cells identified EGFR, TGF- and WNT signaling pathways and several genes such as VAV3, RUNXR2, LEF1, FGFR2 whose expression is upregulated in these cells and therefore a ecting cellular functions such as integrin mediated cell adhesion, focal adhesion and motility. Furthermore, EGF signaling pathway is activated via ERK5 and not ERK1/2 and TGF- via SMAD2/3 in DUSP6 depleted cells. In summary DUSP6 is a tumor suppressor in NSCLC and re-establishment of its expression may be a potential strategy to revert poor outcome in NSCLC patients.spa
dc.language.isoengspa
dc.publisherInternational Journal of Molecular Sciencesspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectDUSP6spa
dc.subjectMKP3spa
dc.subjectTumor suppressorspa
dc.subjectTumorigenesisspa
dc.titleRole of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent2676 KBspa
dc.identifier.doi10.3390/ijms20082036spa


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