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dc.contributor.authorBenito León, Julián
dc.contributor.authorSerrano, J. Ignacio
dc.contributor.authorLouis, Elan D.
dc.contributor.authorHolobar, Ales
dc.contributor.authorRomero Muñoz, Juan Pablo 
dc.contributor.authorPovalej-Bržan, P.
dc.contributor.authorBermejo Pareja, Félix
dc.contributor.authorDel Castillo, María Dolores
dc.contributor.authorPosada, Ignacio J.
dc.contributor.authorRocon, Eduardo
dc.date.accessioned2019-09-10T10:58:30Z
dc.date.available2019-09-10T10:58:30Z
dc.date.issued2018
dc.identifier.issn0360-4012spa
dc.identifier.urihttp://hdl.handle.net/10641/1674
dc.description.abstract. There remains much to learn about the changes in cortical anatomy that are associated with tremor severity in Parkinson’s disease (PD). For this reason, we used a combination of structural neuroimaging to measure cortical thickness and neurophysiological studies to analyze whether PD tremor was associated with cortex integrity. Magnetic resonance imaging and neurophysiological assessment were performed in 13 nondemented PD patients (9 women, 69.2%) with a clearly tremor-dominant phenotype. Cortical reconstruction and volumetric segmentation was performed with the Freesurfer image analysis software. Assessment of tremor was performed by means of high-density surface electromyography (hdEMG) and inertial measurement units (IMUs). Individual motor unit discharge patterns were identified from surface hdEMG and tremor metrics quantifying motor unit synchronization from IMUs were defined. Increased motor unit synchronization (i.e., more severe tremor) was associated with cortical changes (i.e., atrophy) in dorsal premotor cortices, left posterior parietal cortex, left lateral orbitofrontal cortex, cingulate cortex bilaterally, left posterior and transverse temporal cortex, and left occipital lobe, as well as reduced left middle temporal volume. Given that the majority of these areas are involved in controlling movement sequencing, our results support Albert’s classic hypothesis that PD tremor may be the result of an involuntary activation of a program of motor behavior used in the genesis of rapid voluntary alternating movements.spa
dc.language.isoengspa
dc.publisherJournal of Neuroscience Researchspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectCortical thicknessspa
dc.subjectElectromyographyspa
dc.subjectParkinson’s diseasespa
dc.subjectMagnetic resonance imagingspa
dc.subjectTremorspa
dc.titleTremor severity in Parkinson’s disease and cortical changes of areas controlling movement sequencing: a preliminary study.spa
dc.typearticlespa
dc.description.versionpre-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent670 KBspa
dc.identifier.doi10.1002/jnr.24248spa


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España