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dc.contributor.authorPlaza, N.
dc.contributor.authorSimón, D.
dc.contributor.authorSierra Isturiz, Javier 
dc.contributor.authorMoreno Flores, María Teresa 
dc.date.accessioned2019-10-19T08:52:36Z
dc.date.available2019-10-19T08:52:36Z
dc.date.issued2016
dc.identifier.issn0304-3940spa
dc.identifier.urihttp://hdl.handle.net/10641/1697
dc.description.abstractOlfactory ensheathing glia (OEG) cells are known to foster axonal regeneration of central nervous system (CNS) neurons. Several lines of reversibly immortalized human OEG (ihOEG) have been previously established that enabled to develop models for their validation in vitro and in vivo. In this work, a constitutively GFP-expressing ihOEG cell line was obtained, and named Ts14-GFP. Ts14-GFP neuroregenerative ability was similar to that found for the parental line Ts14 and it can be assayed using in vivo transplantation experimental paradigms, after spinal cord or optic nerve damage. Additionally, we have engineered a low-regenerative ihOEG line, hTL2, using lentiviral transduction of the large T antigen from SV40 virus, denominated from now on Ts12. Ts12 can be used as a low regeneration control in these experiments.spa
dc.language.isoengspa
dc.publisherNeuroscience Lettersspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectImmortalized human olfactory ensheathing gliaspa
dc.subjectRetinal ganglion neuronspa
dc.subjectAxonal regenerationspa
dc.subjectGreen fluorescent proteinspa
dc.titleTransduction of an immortalized olfactory ensheathing glia cell line with the green fluorescent protein (GFP) gene: Evaluation of its neuroregenerative capacity as a proof of concept.spa
dc.typejournal articlespa
dc.type.hasVersionSMURspa
dc.rights.accessRightsopen accessspa
dc.description.extent281 KBspa
dc.identifier.doi10.1016/j.neulet.2015.12.001spa


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