Show simple item record

dc.contributor.authorRevilla Yates, Eva
dc.contributor.authorVaras, Laura
dc.contributor.authorSierra Isturiz, Javier 
dc.contributor.authorRodríguez, Isabel
dc.date.accessioned2019-10-19T09:04:32Z
dc.date.available2019-10-19T09:04:32Z
dc.date.issued2015
dc.identifier.issn0014-5793spa
dc.identifier.urihttp://hdl.handle.net/10641/1698
dc.description.abstractThe Drosophila cadherin-related protein Dachsous (Ds) plays a prominent role in planar cell polarity (PCP) and growth. The regulation of these two processes is based on the interaction between Ds and Fat proteins, generating an intracellular response required for tissue polarization and modulation of Hippo pathway activity. Here we have performed a comprehensive molecular study of the ds gene during larval development that has shown an unexpected complexity in its transcriptional regulation and revealed the expression of hitherto unsuspected transcripts. Also, knockdown of several isoforms provides new evidence on the importance of the cytoplasmic domain in the mechanism of action of Ds during development.spa
dc.language.isoengspa
dc.publisherFEBS Lettersspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectDachsous transcriptspa
dc.subjectDrosophilaspa
dc.subjectDsIntra isoformspa
dc.subjectPlanar cell polarityspa
dc.titleTranscriptional analysis of the dachsous gene uncovers novel isoforms expressed during development in Drosophila.spa
dc.typearticlespa
dc.description.versionpre-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent1385 KBspa
dc.identifier.doi10.1016/j.febslet.2015.10.012spa


Files in this item

FilesSizeFormatView
FEBSLETTERS.pdf1.352MbPDFView/Open

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España