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dc.contributor.authorMª Teresa, Grande
dc.contributor.authorLópez Blau, Cristina
dc.contributor.authorSánchez Laorden, Berta
dc.contributor.authorFrutos, Cristina A. de
dc.contributor.authorBoutet, Agnès
dc.contributor.authorGrant Rowe, R.
dc.contributor.authorWeiss, Stephen J.
dc.contributor.authorLópez Novoa, José M.
dc.contributor.authorNieto, M. Angela
dc.date.accessioned2019-11-04T12:14:38Z
dc.date.available2019-11-04T12:14:38Z
dc.date.issued2015
dc.identifier.issn1078-8956spa
dc.identifier.urihttp://hdl.handle.net10641/1713
dc.description.abstractKidney fibrosis is a devastating disease that leads to organ failure, and no specific treatment is available to preserve organ function. In fibrosis, myofibroblasts accumulate in the interstitium leading to massive deposition of extracellular matrix and organ disfunction. The origin of myofibroblasts is multiple and the contribution of renal epithelial cells after undergoing epithelial-to-mesenchymal transition (EMT) is still debated. In a model unable to reactivate the EMT inducer Snail1 upon damage, we show that Snail1 is required in renal epithelial cells for the development of fibrosis. Damage-mediated Snail1 reactivation induces a partial EMT that relays fibrotic and inflammatory signals to the interstitium through the activation of TGF-β and NF-B pathways. Snail1-induced fibrosis can be reverted in vivo and inhibiting Snail1 in a model of obstructive nephropathy highly ameliorates fibrosis. These results reconcile conflicting data on the role of EMT in renal fibrosis and provide avenues for the design of antifibrotic therapies.spa
dc.language.isoengspa
dc.publisherNature Medicinespa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleSnail1 factor behaves as a therapeutic target in renal fibrosis.spa
dc.typearticlespa
dc.description.versionpre-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent8435 KBspa
dc.identifier.doi10.1038/nm.3901spa
dc.relation.publisherversionhttps://www.nature.com/articles/nm.3901spa


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