EEG Microstates Change in Response to Increase in Dopaminergic Stimulation in Typical Parkinson’s Disease Patients.
Autor: Serrano, José Ignacio; Del Castillo, María Dolores; Cortés, Verónica; Mendes, Nuno; Arroyo, Aída; Andreo, Jorge; Rocón, Eduardo; Del Valle, María; Herreros, Jaime; Romero Muñoz, Juan Pablo
Resumen: Objectives: Characterizing pharmacological response in Parkinson’s Disease (PD)
patients may be a challenge in early stages but gives valuable clues for diagnosis.
Neurotropic drugs may modulate Electroencephalography (EEG) microstates (MS). We
investigated EEG-MS default-mode network changes in response to dopaminergic
stimulation in PD.
Methods: Fourteen PD subjects in HY stage III or less were included, and twentyone
healthy controls. All patients were receiving dopaminergic stimulation with levodopa
or dopaminergic agonists. Resting EEG activity was recorded before the first daily PD
medication dose and 1 h after drug intake resting EEG activity was again recorded. Time
and frequency variables for each MS were calculated.
Results: Parkinson’s disease subjects MS A duration decreases after levodopa intake,
MS B appears more often than before levodopa intake. MS E was not present, but MS
G was. There were no significant differences between control subjects and patients after
medication intake.
Conclusion: Clinical response to dopaminergic drugs in PD is characterized by clear
changes in MS profile.
Significance: This work demonstrates that there are clear EEG MS markers of PD
dopaminergic stimulation state. The characterization of the disease and its response to
dopaminergic medication may be of help for early therapeutic diagnosis.
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- MEDICINA [813]