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dc.contributor.authorIbáñez, Jaime
dc.contributor.authorGonzález de la Aleja, Jesús
dc.contributor.authorGallego, Juan A.
dc.contributor.authorRomero Muñoz, Juan Pablo 
dc.contributor.authorSaíz Díaz, Rosana A.
dc.contributor.authorBenito León, Julián
dc.contributor.authorRocón, Eduardo
dc.description.abstractBackground: Essential tremor (ET) is characterised by postural and action tremors with a frequency of 4–12 Hz. Previous studies suggest that the tremor activity originates in the cerebello-thalamocortical pathways. Alprazolam is a short-acting benzodiazepine that attenuates tremors in ET. The mechanisms that mediate the therapeutic action of alprazolam are unknown; however, in healthy subjects, benzodiazepines increase cortical beta activity. In this study, we investigated the effect of alprazolam both on beta and tremor-related cortical activity and on alterations in tremor presentation in ET patients. Therefore, we characterised the dynamics of tremor and cortical activity in ET patients after alprazolam intake. Methods: We recorded hand tremors and contralateral cortical activity in four recordings before and after a single dose of alprazolam. We then computed the changes in tremors, cortico-muscular coherence, and cortical activity at the tremor frequency and in the beta band. Results: Alprazolam significantly attenuated tremors (EMG: 76.2622.68%), decreased cortical activity in the tremor frequency range and increased cortical beta activity in all patients (P,0.05). At the same time, the cortico-muscular coherence at the tremor frequency became non-significant (P,0.05). We also found a significant correlation (r = 0.757, P, 0.001) between the reduction in tremor severity and the increased ratio of cortical activity in the beta band to the activity observed in the tremor frequency range. Conclusions: This study provides the first quantitative analysis of tremor reduction following alprazolam intake. We observed that the tremor severity decreased in association with an increased ratio of beta to tremor-related cortical activity. We hypothesise that the increase in cortical beta activity may act as a blocking mechanism and may dampen the pathological oscillatory activity, which in turn attenuates the observed
dc.publisherPLoS ONEspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.titleEffects of Alprazolam on Cortical Activity and Tremors in Patients with Essential
dc.description.extent685 KBspa

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España