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dc.contributor.authorBenito Léon, Julián
dc.contributor.authorLouis, Elan D.
dc.contributor.authorManzanedo, Eva
dc.contributor.authorHernández-Tamames, Juan Antonio
dc.contributor.authorÁlvarez-Linera, Juan
dc.contributor.authorMolina-Arjona, José Antonio
dc.contributor.authorMatarazzo, Michele
dc.contributor.authorRomero Muñoz, Juan Pablo 
dc.contributor.authorDomínguez-González, Cristina
dc.contributor.authorDomingo-Santos, Ángela
dc.contributor.authorSánchez-Ferro, Álvaro
dc.description.abstractVery little is known about the pathogenesis of orthostatic tremor (OT). We have observed that OT patientsmight have deficits in specific aspects of neuropsychological function, particularly those thought to rely on the integrity of the prefrontal cortex, which suggests a possible involvement of frontocerebellar circuits. We examined whether resting-state functional magnetic resonance imaging (fMRI) might provide further insights into the pathogenesis on OT. Resting-state fMRI data in 13 OT patients (11 women and 2 men) and 13 matched healthy controls were analyzed using independent component analysis, in combination with a “dual-regression” technique, to identify group differences in several resting-state networks (RSNs). All participants also underwent neuropsychological testing during the same session. Relative to healthy controls, OT patients showed increased connectivity in RSNs involved in cognitive processes (default mode network [DMN] and frontoparietal networks), and decreased connectivity in the cerebellumand sensorimotor networks.Changes in network integrity were associated not onlywith duration (DMN and medial visual network), but also with cognitive function. Moreover, in at least 2 networks (DMN and medial visual network), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, visual memory, and language). In this exploratory study, we observed selective impairments ofRSNs inOT patients. This and other future resting-state fMRI studiesmight provide a novelmethod to understand the pathophysiological mechanisms of motor and nonmotor features of
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectCase–control studyspa
dc.subjectFunctional connectivityspa
dc.subjectMagnetic resonance imagingspa
dc.subjectOrthostatic tremorspa
dc.titleResting state functional MRI reveals abnormal network connectivity in orthostatic
dc.description.extent619 KBspa

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España