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dc.contributor.authorBenito Léon, Julián
dc.contributor.authorSanz Morales, Emilio
dc.contributor.authorMelero, Helena
dc.contributor.authorLouis, Elan D.
dc.contributor.authorRomero Muñoz, Juan Pablo 
dc.contributor.authorRocón, Eduardo
dc.contributor.authorMalpica, Norberto
dc.date.accessioned2020-01-21T12:09:26Z
dc.date.available2020-01-21T12:09:26Z
dc.date.issued2019
dc.identifier.issn1065-9471spa
dc.identifier.urihttp://hdl.handle.net/10641/1836
dc.description.abstractEssential tremor (ET) is a neurological disease with both motor and non-motor manifestations; however, little is known about its underlying brain basis. Furthermore, the overall organization of the brain network in ET remains largely unexplored. We investigated the topological properties of brain functional network, derived from resting-state functional MRI data, in 23 ET patients vs. 23 healthy controls. Graph theory analysis was used to assess the functional network organization. At the global level, the functional network of ET patients was characterized by lower small-world values than healthy controls - less clustered functionality of the brain. At the regional level, compared with the healthy controls, ET patients showed significantly higher values of global efficiency, cost and degree, and a shorter average path length in the left inferior frontal gyrus (pars opercularis), right inferior temporal gyrus (posterior division and temporo-occipital part), right inferior lateral occipital cortex, left paracingulate, bilateral precuneus bilaterally, left lingual gyrus, right hippocampus, left amygdala, nucleus accumbens bilaterally, and left middle temporal gyrus. In addition, ET patients showed significant higher local efficiency and clustering coefficient values in the frontal medial cortex bilaterally, subcallosal cortex, posterior cingulate, parahippocampal gyri bilaterally (posterior division), right lingual gyrus, right cerebellar flocculus, right postcentral gyrus, right inferior semilunar lobule of cerebellum and culmen of vermis. In conclusion, the efficiency of the overall brain functional network in ET is disrupted. Further, our results support the concept that ET is a disorder that disrupts widespread brain regions, including those outside of the brain regions responsible for tremor.spa
dc.language.isoengspa
dc.publisherHuman Brain Mappingspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleGraph theory analysis of resting-state functional magnetic resonance imaging in essential tremor.spa
dc.typearticlespa
dc.description.versionpre-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent1168 KBspa
dc.identifier.doi10.1002/hbm.24730spa
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/hbm.24730spa


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España