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dc.contributor.authorGutiérrez Hellín, Jorge
dc.contributor.authorRuiz Moreno, Carlos
dc.contributor.authorDel Coso, Juan
dc.date.accessioned2020-07-02T11:15:23Z
dc.date.available2020-07-02T11:15:23Z
dc.date.issued2019
dc.identifier.issn1436-6207spa
dc.identifier.urihttp://hdl.handle.net10641/1943
dc.description.abstractPurpose p-Synephrine, the principal alkaloid of bitter orange (Citrus aurantium), is widely used in dietary supplements for weight loss due to its purported effect of increasing fat oxidation. However, there is a paucity of scientific information about its effectiveness in enhancing fat oxidation during exercise. The aim of this investigation was to determine the effect of an acute dose of p-synephrine on substrate oxidation during prolonged and constant intensity exercise. Methods In a double-blind and randomized experiment, 14 healthy subjects performed two acute experimental trials after ingesting either p-synephrine (3 mg kg−1) or a placebo (cellulose). Energy expenditure and fat oxidation rates were continuously measured by indirect calorimetry during 1 h of continuous cycling at Fatmax, the intensity that induces maximal fat oxidation rate. Results In comparison to the placebo, energy expenditure during 1 h of cycling remained unchanged with p-synephrine (698 ± 129 vs. 686 ± 123 kcal, P = 0.08). However, p-synephrine increased whole-body fat oxidation (33.6 ± 10.4 vs. 37.3 ± 9.8 g, P < 0.01) while also reducing carbohydrate oxidation (99.5 ± 30.4 vs. 85.0 ± 28.4 g, P < 0.01). However, the magnitude of the shift on substrate oxidation induced by p-synephrine was small. Conclusion Acute ingestion of p-synephrine augments fat oxidation during prolonged and constant-intensity exercise.spa
dc.language.isoengspa
dc.publisherEuropean Journal of Nutritionspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectNutrition supplementspa
dc.subjectExercisespa
dc.subjectCitrus aurantiumspa
dc.subjectBitter orangespa
dc.subjectMaximal fat oxidationspa
dc.titleAcute p-synephrine ingestion increases whole-body fat oxidation during 1-h of cycling at Fatmax.spa
dc.typearticlespa
dc.description.versionpre-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent193 KBspa
dc.identifier.doi10.1007/s00394-019-02101-6spa
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00394-019-02101-6spa


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España