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dc.contributor.authorBribián, Ana
dc.contributor.authorMedina Rodríguez, Eva M.
dc.contributor.authorJosa Prado, Fernando
dc.contributor.authorGarcía Álvarez, Isabel
dc.contributor.authorMachín Díaz, Isabel
dc.contributor.authorEsteban, Pedro F.
dc.contributor.authorMurcia Belmonte, Verónica
dc.contributor.authorVega Zelaya, Lorena
dc.contributor.authorPastor, Jesús
dc.contributor.authorGarrido, Leoncio
dc.contributor.authorDe Castro, Fernando
dc.date.accessioned2020-07-30T09:56:16Z
dc.date.available2020-07-30T09:56:16Z
dc.date.issued2020
dc.identifier.issn2077-0383spa
dc.identifier.urihttp://hdl.handle.net/10641/1961
dc.description.abstractBesides giving rise to oligodendrocytes (the only myelin-forming cell in the Central Nervous System (CNS) in physiological conditions), Oligodendrocyte Precursor Cells (OPCs) are responsible for spontaneous remyelination after a demyelinating lesion. They are present along the mouse and human CNS, both during development and in adulthood, yet how OPC physiological behavior is modified throughout life is not fully understood. The activity of adult human OPCs is still particularly unexplored. Significantly, most of the molecules involved in OPC-mediated remyelination are also involved in their development, a phenomenon that may be clinically relevant. In the present article, we have compared the intrinsic properties of OPCs isolated from the cerebral cortex of neonatal, postnatal and adult mice, as well as those recovered from neurosurgical adult human cerebral cortex tissue. By analyzing intact OPCs for the first time with 1H High Resolution Magic Angle Spinning Nuclear Magnetic Resonance (1H HR-MAS NMR) spectroscopy, we show that these cells behave distinctly and that they have different metabolic patterns in function for their stage of maturity. Moreover, their response to Fibroblast Growth Gactor-2 (FGF-2) and anosmin-1 (two molecules that have known effects on OPC biology during development and that are overexpressed in individuals with Multiple Sclerosis (MS)) differs in relation to their developmental stage and in the function of the species. Our data reveal that the behavior of adult human and mouse OPCs differs in a very dynamic way that should be very relevant when testing drugs and for the proper design of effective pharmacological and/or cell therapies for MS.spa
dc.language.isoengspa
dc.publisherJournal of Clinical Medicinespa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectOligodendrocytespa
dc.subjectMyelinspa
dc.subjectMultiple sclerosisspa
dc.subjectRemyelinationspa
dc.subjectLeukodystrophiesspa
dc.subjectDemyelinationspa
dc.titleFunctional Heterogeneity of Mouse and Human Brain OPCs: Relevance for Preclinical Studies in Multiple Sclerosis.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent753 KBspa
dc.identifier.doi10.3390/jcm9061681spa
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/9/6/1681spa


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