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dc.contributor.authorGarcía Romero, Noemí 
dc.contributor.authorPalacín Aliana, I.
dc.contributor.authorEsteban Rubio, S.
dc.contributor.authorMadurga Lacalle, Rodrigo 
dc.contributor.authorRius Rocabert, Sergio
dc.contributor.authorCarrión Navarro, Josefa
dc.contributor.authorPresa, Jesús
dc.contributor.authorCuadrado Castano, Sara
dc.contributor.authorSánchez Gómez, Pilar
dc.contributor.authorGarcía Sastre, Adolfo
dc.contributor.authorNistal Villan, Estanislao
dc.contributor.authorAyuso Sacido, Ángel
dc.description.abstractGlioblastoma (GBM) is the most aggressive and frequent primary brain tumor in adults with a median overall survival of 15 months. Tumor recurrence and poor prognosis are related to cancer stem cells (CSCs), which drive resistance to therapies. A common characteristic in GBM is CDKN2A gene loss, located close to the cluster of type I IFN genes at Ch9p21. Newcastle disease virus (NDV) is an avian paramyxovirus with oncolytic and immunostimulatory properties that has been proposed for the treatment of GBM. We have analyzed the CDKN2A-IFN I gene cluster in 1018 glioma tumors and evaluated the NDV oncolytic e ect in six GBM CSCs ex vivo and in a mouse model. Our results indicate that more than 50% of GBM patients have some IFN deletion. Moreover, GBM susceptibility to NDV is dependent on the loss of the type I IFN. Infection of GBM with an NDV-expressing influenza virus NS1 protein can overcome the resistance to oncolysis by NDV of type I-competent cells. These results highlight the potential of using NDV vectors in antitumor
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectOncolytic virotherapyspa
dc.subjectNewcastle disease virus (NDV)spa
dc.subjectInterferon Ispa
dc.titleNewcastle Disease Virus (NDV) Oncolytic Activity in Human Glioma Tumors Is Dependent on CDKN2A-Type I IFN Gene Cluster
dc.description.extent3309 KBspa

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España