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dc.contributor.authorVarillas Delgado, David 
dc.contributor.authorTellería Orriols, Juan José
dc.contributor.authorMartín Saborido, Carlos 
dc.date.accessioned2020-11-26T19:39:20Z
dc.date.available2020-11-26T19:39:20Z
dc.date.issued2019
dc.identifier.issn2198-9761spa
dc.identifier.urihttp://hdl.handle.net/10641/2116
dc.description.abstractBackground: The genetic profile that is needed to define an endurance athlete has been studied during recent years. The main objective of this work is to approach for the first time the study of genetic variants in livermetabolizing genes and their role in endurance performance by comparing the allelic and genotypic frequencies in elite endurance athletes to the non-athlete population. Methods: Genotypic and allelic frequencies were determined in 123 elite endurance athletes (75 professional road cyclists and 48 endurance elite runners) and 122 male non-athlete subjects (sedentary). Genotyping of cytochrome P450 family 2 subfamily D member 6 (CYP2D6 rs3892097), glutathione-S transferase mu isoform 1 (GSTM1), glutathione S-transferase pi (GSTP rs1695) and glutathione S-transferase theta (GSTT) genes was performed by polymerase chain reaction (PCR). The combination of the polymorphisms for the “optimal” polygenic profile has been quantified using the genotype score (GS). Results: Statistical differences were found in the genetic distributions between elite endurance athletes and nonathletes in CYP2D6 (p < 0.001) and GSTT (p = 0.014) genes. The binary logistic regression model showed a favourable OR (odds ratio) of being an elite endurance runner against a professional road cyclist (OR: 2.403, 95% CI:1.213–4.760 (p = 0.002)) in the polymorphisms studied. Conclusions: Genotypic distribution of liver-metabolizing genes in elite endurance athletes is different to nonathlete subjects, with a favourable gene profile in elite endurance athletes in terms of detoxification capacity.spa
dc.language.isoengspa
dc.publisherSports Medicine - Openspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectPhysical endurancespa
dc.subjectPerformancespa
dc.subjectSportsspa
dc.subjectCYP2D6spa
dc.subjectCytochrome p 450spa
dc.subjectGlutathione transferasesspa
dc.titleLiver-Metabolizing Genes and Their Relationship to the Performance of Elite Spanish Male Endurance Athletes; a Prospective Transversal Study.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent814 KBspa
dc.identifier.doi10.1186/s40798-019-0227-7spa
dc.relation.publisherversionhttps://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-019-0227-7spa


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España