Show simple item record

dc.contributor.authorSan Mauro Martín, Ismael
dc.contributor.authorGaricano Vilar, Elena
dc.contributor.authorSanz Rojo, Sara
dc.contributor.authorCollado Yurrita, Luis
dc.contributor.authorPérez Arruche, Eva
dc.contributor.authorArce Delgado, Esperanza
dc.contributor.authorBlumenfeld Olivares, Javier Andrés
dc.date.accessioned2020-12-09T10:15:40Z
dc.date.available2020-12-09T10:15:40Z
dc.date.issued2019
dc.identifier.issn2072-6643spa
dc.identifier.urihttp://hdl.handle.net/10641/2124
dc.description.abstractCardiovascular disease is linked to high serum low density lipoprotein (LDL)-cholesterol levels. Cardiovascular risk may be indirectly influenced by genetic load. Serum LDL-cholesterol levels may be reduced by the consumption of food enriched with plant sterols (PS). The aim was to test a plant sterol treatment on cholesterol levels according to different genetic polymorphisms. A pilot interventional trial was performed in 26 children (n = 16 girls, n = 10 boys). Seven hundred milliliters/day of commercial skimmed milk with added plant sterols delivering 2.2 g plant sterols were ingested for three weeks. Blood draws were performed at the baseline and end of the study. Significant modifications of non-high density lipoprotein (HDL)-cholesterol (p = 0.010; p = 0.013) and LDL-cholesterol (p = 0.004; p = 0.013) levels appeared in the genes LIPC C-514T and PPAR-α L162V carriers. No statistically significant differences were observed for other genes. LIPC C-514T and PPAR-alpha L162V carriers could benefit from a plant sterol supplement to ameliorate hypercholesterolemia.spa
dc.language.isoengspa
dc.publisherNutrientsspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectCholesterolspa
dc.subjectGeneticsspa
dc.subjectLow-density lipoprotein cholesterolspa
dc.subjectSterolspa
dc.titleGene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent1,25 MBspa
dc.identifier.doi10.3390/nu11102538spa
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/11/10/2538/xmlspa


Files in this item

FilesSizeFormatView
nutrients-11-02538-v2.pdf1.259MbPDFView/Open

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España