dc.contributor.author | San Mauro Martín, Ismael | |
dc.contributor.author | Garicano Vilar, Elena | |
dc.contributor.author | Sanz Rojo, Sara | |
dc.contributor.author | Collado Yurrita, Luis | |
dc.contributor.author | Pérez Arruche, Eva | |
dc.contributor.author | Arce Delgado, Esperanza | |
dc.contributor.author | Blumenfeld Olivares, Javier Andrés | |
dc.date.accessioned | 2020-12-09T10:15:40Z | |
dc.date.available | 2020-12-09T10:15:40Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2072-6643 | spa |
dc.identifier.uri | http://hdl.handle.net/10641/2124 | |
dc.description.abstract | Cardiovascular disease is linked to high serum low density lipoprotein (LDL)-cholesterol
levels. Cardiovascular risk may be indirectly influenced by genetic load. Serum LDL-cholesterol
levels may be reduced by the consumption of food enriched with plant sterols (PS). The aim was
to test a plant sterol treatment on cholesterol levels according to different genetic polymorphisms.
A pilot interventional trial was performed in 26 children (n = 16 girls, n = 10 boys). Seven
hundred milliliters/day of commercial skimmed milk with added plant sterols delivering 2.2 g
plant sterols were ingested for three weeks. Blood draws were performed at the baseline and
end of the study. Significant modifications of non-high density lipoprotein (HDL)-cholesterol
(p = 0.010; p = 0.013) and LDL-cholesterol (p = 0.004; p = 0.013) levels appeared in the genes LIPC
C-514T and PPAR-α L162V carriers. No statistically significant differences were observed for other
genes. LIPC C-514T and PPAR-alpha L162V carriers could benefit from a plant sterol supplement to
ameliorate hypercholesterolemia. | spa |
dc.language.iso | eng | spa |
dc.publisher | Nutrients | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Cholesterol | spa |
dc.subject | Genetics | spa |
dc.subject | Low-density lipoprotein cholesterol | spa |
dc.subject | Sterol | spa |
dc.title | Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dc.rights.accessRights | open access | spa |
dc.description.extent | 1,25 MB | spa |
dc.identifier.doi | 10.3390/nu11102538 | spa |
dc.relation.publisherversion | https://www.mdpi.com/2072-6643/11/10/2538/xml | spa |