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dc.contributor.authorGarcía García, Gracia
dc.contributor.authorFernández Álvarez, Fátima
dc.contributor.authorCabeza, Laura
dc.contributor.authorDelgado, Ángel V.
dc.contributor.authorMelguizo, Consolación
dc.contributor.authorPrados, José C.
dc.contributor.authorArias, José L.
dc.date.accessioned2021-01-13T17:00:01Z
dc.date.available2021-01-13T17:00:01Z
dc.date.issued2020
dc.identifier.issn2073-4360spa
dc.identifier.urihttp://hdl.handle.net/10641/2167
dc.description.abstractA reproducible and efficient interfacial polymer disposition method has been used to formulatemagnetite/poly("-caprolactone) (core/shell) nanoparticles (average size 125 nm, production performance 90%). To demonstrate that the iron oxide nuclei were satisfactorily embedded within the polymeric solid matrix, a complete analysis of these nanocomposites by, e.g., electron microscopy visualizations, energy dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, electrophoresis, and contact angle goniometry was conducted. The magnetic responsive behaviour of these nanoparticles was quantitatively characterized by the hysteresis cycle and qualitatively investigated by visualization of the colloid under exposure to a 0.4 T magnet. Gemcitabine entrapment into the polymeric shell reported adequate drug loading values ( 11%), and a biphasic and pH-responsive drug release profile ( four-fold faster Gemcitabine release at pH 5.0 compared to pH 7.4). Cytotoxicity studies in MCF-7 human breast cancer cells proved that the half maximal inhibitory concentration of Gem-loaded nanocomposites was two-fold less than that of the free drug. Therefore, these core/shell nanoparticles could have great possibilities as a magnetically targeted Gemcitabine delivery system for breast cancer treatment.spa
dc.language.isoengspa
dc.publisherPolymersspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectBreast cancerspa
dc.subjectDrug loadingspa
dc.subjectGemcitabinespa
dc.subjectMagnetic drug deliveryspa
dc.subjectMagnetitespa
dc.subjectPH-responsive drug releasespa
dc.subjectPolymer-coated nanoparticlespa
dc.titleGemcitabine-Loaded Magnetically Responsive Poly("-caprolactone) Nanoparticles against Breast Cancer.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent3677 KBspa
dc.identifier.doi10.3390/polym12122790spa
dc.relation.publisherversionhttps://www.mdpi.com/2073-4360/12/12/2790spa


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España