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dc.contributor.authorGutiérrez Hellín, Jorge 
dc.contributor.authorBaltazar Martins, Gabriel
dc.contributor.authorAguilar Navarro, Millán 
dc.contributor.authorOliván, Jesús
dc.contributor.authorDel Coso, Juan
dc.date.accessioned2021-01-29T09:57:51Z
dc.date.available2021-01-29T09:57:51Z
dc.date.issued2021
dc.identifier.issn2073-4425spa
dc.identifier.urihttp://hdl.handle.net/10641/2202
dc.description.abstractThe p.R577X polymorphism (rs1815739) in the ACTN3 gene causes individuals with the ACTN3 XX genotype to be deficient in functional α-actinin-3. Previous investigations have found that XX athletes are more prone to suffer non-contact muscle injuries. This investigation aimed to determine the influence of the ACTN3 R577X polymorphism in the injury epidemiology of elite endurance athletes. Using a cross-sectional experiment, the epidemiology of running-related injuries was recorded for one season in a group of 89 Spanish elite endurance runners. ACTN3 R577X genotype was obtained for each athlete using genomic DNA samples. From the study sample, 42.7% of athletes had the RR genotype, 39.3% had the RX genotype, and 18.0% had the XX genotype. A total of 96 injuries were recorded in 57 athletes. Injury incidence was higher in RR runners (3.2 injuries/1000 h of running) than in RX (2.0 injuries/1000 h) and XX (2.2 injuries/1000 h; p = 0.030) runners. RR runners had a higher proportion of injuries located in the Achilles tendon, RX runners had a higher proportion of injuries located in the knee, and XX runners had a higher proportion of injuries located in the groin (p = 0.025). The ACTN3 genotype did not affect the mode of onset, the severity, or the type of injury. The ACTN3 genotype slightly affected the injury epidemiology of elite endurance athletes with a higher injury rate in RR athletes and differences in injury location. However, elite ACTN3 XX endurance runners were not more prone to muscle-type injuries.spa
dc.language.isoengspa
dc.publisherGenesspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectAthletic performancespa
dc.subjectExercise-related injuryspa
dc.subjectSingle nucleotide polymorphismspa
dc.subjectTrack and field athletespa
dc.titleEffect of ACTN3 R577X Genotype on Injury Epidemiology in Elite Endurance Runners´.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent248 KBspa
dc.identifier.doi10.3390/genes12010076spa
dc.relation.publisherversionhttps://www.mdpi.com/2073-4425/12/1/76spa


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