Mostrar el registro sencillo del ítem

dc.contributor.authorMontalvo Quiros, Sandra
dc.contributor.authorGómez Graña, Sergio
dc.contributor.authorVallet Regí, María
dc.contributor.authorPrados Rosales, Rafael C.
dc.contributor.authorGonzález, Blanca
dc.contributor.authorLuque García, José L.
dc.date.accessioned2021-02-12T10:57:03Z
dc.date.available2021-02-12T10:57:03Z
dc.date.issued2020
dc.identifier.issn0927-7765spa
dc.identifier.urihttp://hdl.handle.net/10641/2218
dc.description.abstractTuberculosis remains today a major public health issue with a total of 9 million new cases and 2 million deaths annually. The lack of an effective vaccine and the increasing emergence of new strains of Mycobacterium tuberculosis (Mtb) highly resistant to antibiotics, anticipate a complicated scenario in the near future. The use of nanoparticles features as an alternative to antibiotics in tackling this problem due to their potential effectiveness in resistant bacterial strains. In this context, silver nanoparticles have demonstrated high bactericidal efficacy, although their use is limited by their relatively high toxicity, which calls for the design of nanocarriers that allow silver based nanoparticles to be safely delivered to the target cells or tissues. In this work mesoporous silica nanoparticles are used as carriers of silver based nanoparticles as antimycobacterial agent against Mtb. Two different synthetic approaches have been used to afford, on the one hand, a 2D hexagonal mesoporous silica nanosystem which contains silver bromide nanoparticles distributed all through the silica network and, on the other hand, a core@shell nanosystem with metallic silver nanoparticles as core and mesoporous silica shell in a radial mesoporous rearrangement. Both materials have demonstrated good antimycobacterial capacity in in vitro test using Mtb, being lower the minimum inhibitory concentration for the nanosystem which contains silver bromide. Therefore, the interaction of this material with the mycobacterial cell has been studied by cryo-electron microscopy, establishing a direct connection between the antimycobactericidal effect observed and the damage induced in the cell envelope.spa
dc.language.isoengspa
dc.publisherColloids and Surfaces B: Biointerfacesspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectAntimycobacterial agentsspa
dc.subjectMycobacterium tuberculosisspa
dc.subjectTuberculosisspa
dc.subjectSilver nanoparticlesspa
dc.subjectMesoporous silica nanoparticlesspa
dc.subjectBacteria wall disruptionspa
dc.titleMesoporous silica nanoparticles containing silver as novel antimycobacterial agents against Mycobacterium tuberculosis.spa
dc.typejournal articlespa
dc.type.hasVersionSMURspa
dc.rights.accessRightsopen accessspa
dc.description.extent1674 KBspa
dc.identifier.doi10.1016/j.colsurfb.2020.111405spa
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S092777652030761Xspa


Ficheros en el ítem

FicherosTamañoFormatoVer
1.- Mesoporous silica nanoparticles ...1.634MbPDFVer/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución-NoComercial-SinDerivadas 3.0 España
Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución-NoComercial-SinDerivadas 3.0 España