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dc.contributor.authorGarcía Prado, Javier
dc.contributor.authorGonzález Hernando, Concepción
dc.contributor.authorVarillas Delgado, David 
dc.contributor.authorSaiz Martínez, Raquel
dc.contributor.authorBhosale, Priya
dc.contributor.authorBlazquez Sanchez, Javier
dc.contributor.authorChiva, Luis
dc.description.abstractPurpose Ovarian cancer (OC) is the commonest cause of death by gynaecological cancer in developed countries. Peritoneal carcinomatosis (PC) complete debulking without residual disease of >1 cm is the best prognostic predictor in advanced OC. PC is assessed with Computed tomography (CT). CT accuracy and cytoreduction success predictive ability are limited. PET/CT is not an imaging standard for PC. PC shows high signal foci in Diffusion-weighted magnetic resonance imaging (DWI MRI). We assessed the diagnostic performance (DP) and tumour burden correlation of Whole body DWI with background suppression MRI (WB-DWIBS/MRI) in PC of suspected OC using the Peritoneal Cancer Index (PCI), referring to cytoreduction surgery as the standard reference. Method Fifty patients with suspicion of disseminated OC underwent cytoreduction and WB-DWIBS/MRI. The PCI scores tumour burden (0–3) in 13 anatomical regions (global range of 0–39). Two radiologists (Rad1/Rad2) assessed the PCI preoperatively and with surgical findings. We evaluated regional and global DP, the interobserver agreement (Cohen´s kappa coefficient), statistical differences (McNemar test) and tumour burden (Pearson’s test). Results 72% (36/50) were epithelial OC and 78% (39/50) achieved complete cytoreduction. Global-PCI correlation was 0.762 (Rad1) with DP: Sensitivity 0.84, specificity 0.89, accuracy 0.89, and kappa 0.41. Average global-PCI was 7. The pelvis and right hypochondrium showed the highest positive rate and DP, while the intestinal regions presented the lowest. Previous studies reported higher sensitivity than CT or PET/CT, although only a few used the PCI. Conclusions WB-DWIBS/MRI is reliable to depict, quantify and to predict complete cytoreductive surgery in OC
dc.publisherEuropean Journal of Radiologyspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectPeritoneal carcinomatosisspa
dc.subjectMR imagingspa
dc.subjectOvarian cancerspa
dc.subjectWhole-body magnetic resonance imagingspa
dc.subjectDiffusion weighted imagingspa
dc.titleDiffusion-Weighted Magnetic Resonance Imaging in Peritoneal Carcinomatosis from Ovarian Cancer: Diagnostic performance in correlation with surgical
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