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dc.contributor.authorMartínez Relimpio, Ana María 
dc.contributor.authorBenito, Marta
dc.contributor.authorPérez Izquierdo, Elena
dc.contributor.authorTeijón, César
dc.contributor.authorOlmo, Rosa María
dc.contributor.authorBlanco, María Dolores
dc.date.accessioned2021-07-26T12:06:31Z
dc.date.available2021-07-26T12:06:31Z
dc.date.issued2021
dc.identifier.issn2073-4360spa
dc.identifier.urihttp://hdl.handle.net/10641/2365
dc.description.abstractAmong the different ways to reduce the secondary effects of antineoplastic drugs in cancer treatment, the use of nanoparticles has demonstrated good results due to the protection of the drug and the possibility of releasing compounds to a specific therapeutic target. The -isoform of the folate receptor (FR) is overexpressed on a significant number of human cancers; therefore, folate-targeted crosslinked nanoparticles based on BSA and alginate mixtures and loaded with paclitaxel (PTX) have been prepared to maximize the proven antineoplastic activity of the drug against solid tumors. Nanometric-range-sized particles (169 28 nm–296 57 nm), with negative Z-potential values (between �����0.12 0.04 and �����94.1 0.4), were synthesized, and the loaded PTX (2.63 0.19–3.56 0.13 g PTX/mg Np) was sustainably released for 23 and 27 h. Three cell lines (MCF-7, MDA-MB-231 and HeLa) were selected to test the efficacy of the folate-targeted PTX-loaded BSA/ALG nanocarriers. The presence of FR on the cell membrane led to a significantly larger uptake of BSA/ALG–Fol nanoparticles compared with the equivalent nanoparticles without folic acid on their surface. The cell viability results demonstrated a cytocompatibility of unloaded nanoparticle– Fol and a gradual decrease in cell viability after treatment with PTX-loaded nanoparticle–Fol due to the sustainable PTX release.spa
dc.language.isoengspa
dc.publisherPolymersspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectFolate-targeted nanoparticlesspa
dc.subjectBSA/alginate nanocarriersspa
dc.subjectPaclitaxelspa
dc.subjectCellular uptakespa
dc.subjectCell viabilityspa
dc.titlePaclitaxel-Loaded Folate-Targeted Albumin-Alginate Nanoparticles Crosslinked with Ethylenediamine. Synthesis and In Vitro Characterization.spa
dc.typejournal articlespa
dc.type.hasVersionAMspa
dc.rights.accessRightsopen accessspa
dc.description.extent2347 KBspa
dc.identifier.doi10.3390/polym13132083spa
dc.relation.publisherversionhttps://www.mdpi.com/2073-4360/13/13/2083spa


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España