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dc.contributor.authorFernández‑Chacón, Macarena
dc.contributor.authorGarcía‑González, Irene
dc.contributor.authorMühleder, Severin
dc.contributor.authorBenedito, Rui
dc.date.accessioned2021-11-04T11:59:58Z
dc.date.available2021-11-04T11:59:58Z
dc.date.issued2021
dc.identifier.issn0969-6970spa
dc.identifier.urihttp://hdl.handle.net/10641/2584
dc.description.abstractThe Notch signalling pathway is one of the main regulators of endothelial biology. In the last 20 years the critical function of Notch has been uncovered in the context of angiogenesis, participating in tip-stalk specification, arterial-venous differentiation, vessel stabilization, and maturation processes. Importantly, pharmacological compounds targeting distinct members of the Notch signalling pathway have been used in the clinics for cancer therapy. However, the underlying mechanisms that support the variety of outcomes triggered by Notch in apparently opposite contexts such as angiogenesis and vascular homeostasis remain unknown. In recent years, advances in -omics technologies together with mosaic analysis and high molecular, cellular and temporal resolution studies have allowed a better understanding of the mechanisms driven by the Notch signalling pathway in different endothelial contexts. In this review we will focus on the main findings that revisit the role of Notch signalling in vascular biology. We will also discuss potential future directions and technologies that will shed light on the puzzling role of Notch during endothelial growth and homeostasis. Addressing these open questions may allow the improvement and development of therapeutic strategies based on modulation of the Notch signalling pathway.spa
dc.language.isoengspa
dc.publisherAngiogenesisspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectNotch signallingspa
dc.subjectEndothelial cellsspa
dc.subjectAngiogenesisspa
dc.subjectVascular homeostasisspa
dc.subjectArterial-venous specificationspa
dc.titleRole of Notch in endothelial biology.spa
dc.typearticlespa
dc.description.versionpre-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent1.454 KBspa
dc.identifier.doi10.1007/s10456-021-09793-7spa
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs10456-021-09793-7spa


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España