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dc.contributor.authorFernández Álvarez, Fátima
dc.contributor.authorGarcía García, Gracia
dc.contributor.authorArias, José L.
dc.date.accessioned2021-11-11T12:03:55Z
dc.date.available2021-11-11T12:03:55Z
dc.date.issued2021
dc.identifier.issn1999-4923spa
dc.identifier.urihttp://hdl.handle.net/10641/2603
dc.description.abstractA (core/shell)/shell nanostructure (production performance 50%,mean diameter 330 nm) was built using maghemite, PLGA, and chitosan. An extensive characterization proved the complete inclusion of the maghemite nuclei into the PLGA matrix (by nanoprecipitation solvent evaporation) and the disposition of the chitosan shell onto the nanocomposite (by coacervation). Short-term stability and the adequate magnetism of the nanocomposites were demonstrated by size and electrokinetic determinations, and by defining the first magnetization curve and the responsiveness of the colloid to a permanent magnet, respectively. Safety of the nanoparticles was postulated when considering the results from blood compatibility studies, and toxicity assays against human colonic CCD-18 fibroblasts and colon carcinoma T-84 cells. Cisplatin incorporation to the PLGA matrix generated appropriate loading values ( 15%), and a dual pH- and heat (hyperthermia)-responsive drug release behaviour ( 4.7-fold faster release at pH 5.0 and 45 C compared to pH 7.4 and 37 C). The half maximal inhibitory concentration of the cisplatin-loaded nanoparticles against human lung adenocarcinoma A-549 cells was 1.6-fold less than that of the free chemotherapeutic. Such a biocompatible and tri-stimuli responsive (maghemite/PLGA)/chitosan nanostructure may found a promising use for the effective treatment of lung cancer.spa
dc.language.isoengspa
dc.publisherPharmaceuticsspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectChitosanspa
dc.subjectHeat-triggered drug releasespa
dc.subjectMagnetic drug deliveryspa
dc.subjectpH-responsive drug releasespa
dc.subjectPLGAspa
dc.subjectTriple stimuli-responsive nanoparticlespa
dc.titleA Tri-Stimuli Responsive (Maghemite/PLGA)/Chitosan Nanostructure with Promising Applications in Lung Cancer.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent3.660 KBspa
dc.identifier.doi10.3390/pharmaceutics13081232spa
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/13/8/1232spa


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España