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dc.contributor.authorDuraj, Tomás
dc.contributor.authorCarrión Navarro, Josefa
dc.contributor.authorSeyfried, Thomas N.
dc.contributor.authorGarcía Romero, Noemí 
dc.contributor.authorAyuso Sacido, Ángel 
dc.date.accessioned2022-01-13T12:47:13Z
dc.date.available2022-01-13T12:47:13Z
dc.date.issued2021
dc.identifier.issn2212-8778spa
dc.identifier.urihttp://hdl.handle.net/10641/2659
dc.description.abstractBackground Aberrant metabolism is recognized as a hallmark of cancer, a pillar necessary for cellular proliferation. Regarding bioenergetics (ATP generation), most cancers display a preference not only toward aerobic glycolysis (“Warburg effect”) and glutaminolysis (mitochondrial substrate level-phosphorylation) but also toward other metabolites such as lactate, pyruvate, and fat-derived sources. These secondary metabolites can assist in proliferation but cannot fully cover ATP demands. Scope of review The concept of a static metabolic profile is challenged by instances of heterogeneity and flexibility to meet fuel/anaplerotic demands. Although metabolic therapies are a promising tool to improve therapeutic outcomes, either via pharmacological targets or press-pulse interventions, metabolic plasticity is rarely considered. Lack of bioenergetic analysis in vitro and patient-derived models is hindering translational potential. Here, we review the bioenergetics of cancer and propose a simple analysis of major metabolic pathways, encompassing both affordable and advanced techniques. A comprehensive compendium of Seahorse XF bioenergetic measurements is presented for the first time. Major conclusions Standardization of principal readouts might help researchers to collect a complete metabolic picture of cancer using the most appropriate methods depending on the sample of interest.spa
dc.language.isoengspa
dc.publisherMolecular Metabolismspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectCancerspa
dc.subjectEnergy metabolismspa
dc.subjectGlycolysisspa
dc.subjectOxidative phosphorylationspa
dc.subjectResearch designspa
dc.titleMetabolic therapy and bioenergetic analysis: The missing piece of the puzzle.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent3250 KBspa
dc.identifier.doi10.1016/j.molmet.2021.101389spa
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2212877821002404?via%3Dihubspa


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España