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dc.contributor.authorSaravia, Rocío
dc.contributor.authorTen Blanco, Marc
dc.contributor.authorPereda Pérez, Inmaculada
dc.contributor.authorBerrendero, Fernando 
dc.date.accessioned2022-01-14T11:49:09Z
dc.date.available2022-01-14T11:49:09Z
dc.date.issued2021
dc.identifier.issn1422-0067spa
dc.identifier.urihttp://hdl.handle.net/10641/2686
dc.description.abstractNicotine, the main psychoactive component in tobacco smoke, plays a major role in tobacco addiction, producing a high morbidity and mortality in the world. A great amount of research has been developed to elucidate the neural pathways and neurotransmitter systems involved in such a complex addictive behavior. The endocannabinoid system, which has been reported to participate in the addictive properties of most of the prototypical drugs of abuse, is also implicated in nicotine dependence. This review summarizes and updates the main behavioral and biochemical data involving the endocannabinoid system in the rewarding properties of nicotine as well as in nicotine withdrawal and relapse to nicotine‐seeking behavior. Promising results from preclinical studies suggest that manipulation of the endocannabinoid system could be a potential therapeutic strategy for treating nicotine addiction.spa
dc.language.isoengspa
dc.publisherInternational Journal of Molecular Sciencesspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectNicotinespa
dc.subjectCannabinoidspa
dc.subjectWithdrawalspa
dc.subjectAnandamidespa
dc.subject2‐ arachidonoylglycerolspa
dc.titleNew Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent641 KBspa
dc.identifier.doi10.3390/ijms222413316spa
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/22/24/13316spa


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España