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dc.contributor.authorEspada, Jesús
dc.contributor.authorCarrasco, Elisa
dc.contributor.authorCalvo Sánchez, María Inmaculada
dc.contributor.authorFernández Martos, Sandra
dc.contributor.authorMontoya, Juan José
dc.date.accessioned2022-01-24T12:49:02Z
dc.date.available2022-01-24T12:49:02Z
dc.date.issued2020
dc.identifier.issn1940-087Xspa
dc.identifier.urihttp://hdl.handle.net/10641/2714
dc.description.abstractHere, we describe a protocol to induce switchable in vivo photogeneration of endogenous reactive oxygen species (ROS) in mouse skin. This transient production of ROS in situ efficiently activates cell proliferation in stem cell niches and stimulates tissue regeneration as strongly manifested through the acceleration of burn healing and hair follicle growth processes. The protocol is based on a regulatable photodynamic treatment that treats the tissue with precursors of the endogenous photosensitizer protoporphyrin IX and further irradiates the tissue with red light under tightly controlled physicochemical parameters. Overall, this protocol constitutes an interesting experimental tool to analyze ROS biology.spa
dc.language.isoengspa
dc.publisherJournal of Visualized Experimentsspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleStimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Pho togeneration of Reactive Oxygen Species In Situ.spa
dc.typejournal articlespa
dc.type.hasVersionSMURspa
dc.rights.accessRightsopen accessspa
dc.description.extent245 KBspa
dc.identifier.doi10.3791/60859spa
dc.relation.publisherversionhttps://www.jove.com/es/t/60859/stimulation-stem-cell-niches-tissue-regeneration-mouse-skinspa


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España