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dc.contributor.authorMori, Francesca
dc.contributor.authorGiovannini, Mattia
dc.contributor.authorBarni, Simona
dc.contributor.authorJiménez-Saiz, Rodrigo
dc.contributor.authorMunblit, Daniel
dc.contributor.authorBiagioni, Benedetta
dc.contributor.authorLiccioli, Giulia
dc.contributor.authorSarti, Lucrezia
dc.contributor.authorLiotti, Lucia
dc.contributor.authorRicci, Silvia
dc.contributor.authorNovembre, Elio
dc.contributor.authorSahiner, Umit
dc.contributor.authorBaldo, Ermanno
dc.contributor.authorCaimmi, Davide
dc.date.accessioned2022-02-18T08:39:10Z
dc.date.available2022-02-18T08:39:10Z
dc.date.issued2021
dc.identifier.issn1664-3224spa
dc.identifier.urihttp://hdl.handle.net/10641/2836
dc.description.abstractThe prevalence of food allergy has increased in recent years, especially in children. Allergen avoidance, and drugs in case of an allergic reaction, remains the standard of care in food allergy. Nevertheless, increasing attention has been given to the possibility to treat food allergy, through immunotherapy, particularly oral immunotherapy (OIT). Several OIT protocols and clinical trials have been published. Most of them focus on children allergic to milk, egg, or peanut, although recent studies developed protocols for other foods, such as wheat and different nuts. OIT efficacy in randomized controlled trials is usually evaluated as the possibility for patients to achieve desensitization through the consumption of an increasing amount of a food allergen, while the issue of a possible long-term sustained unresponsiveness has not been completely addressed. Here, we evaluated current pediatric OIT knowledge, focusing on the results of clinical trials and current guidelines. Specifically, we wanted to highlight what is known in terms of OIT efficacy and effectiveness, safety, and impact on quality of life. For each aspect, we reported the pros and the cons, inferable from published literature. In conclusion, even though many protocols, reviews and meta-analysis have been published on this topic, pediatric OIT remains a controversial therapy and no definitive generalized conclusion may be drawn so far. It should be an option provided by specialized teams, when both patients and their families are prone to adhere to the proposed protocol. Efficacy, long-term effectiveness, possible role of adjuvant therapies, risk of severe reactions including anaphylaxis or eosinophilic esophagitis, and impact on the quality of life of both children and caregivers are all aspects that should be discussed before starting OIT. Future studies are needed to provide firm clinical and scientific evidence, which should also consider patient reported outcomes.spa
dc.language.isoengspa
dc.publisherFrontiers in Immunologyspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectFood allergyspa
dc.subjectOral immunotherapyspa
dc.subjectAnaphylaxisspa
dc.subjectPediatricsspa
dc.titleOral Immunotherapy for Food-Allergic Children: A Pro-Con Debate.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent6382 KBspa
dc.identifier.doi10.3389/fimmu.2021.636612spa
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.636612/fullspa


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España