dc.contributor.author | Coronado, Pluvio | |
dc.contributor.author | De Santiago López, Javier | |
dc.contributor.author | De Santiago García, Javier | |
dc.contributor.author | Méndez, Ramiro | |
dc.contributor.author | Fasero Laiz, María | |
dc.contributor.author | Herraiz, Miguel A. | |
dc.date.accessioned | 2022-02-22T12:34:32Z | |
dc.date.available | 2022-02-22T12:34:32Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1581-3207 | spa |
dc.identifier.uri | http://hdl.handle.net/10641/2851 | |
dc.description.abstract | Background. The aim of the study was to determine if the endometrial tumor volume (TV) measured by magnetic
resonance imaging (MRI-TV) is associated with survival in endometrial cancer and lymph nodes metastases (LN+).
Patients and methods. We evaluated the MRI imaging and records of 341 women with endometrial cancer and
preoperative MRI from 2008 to 2018. The MRI-TV was calculated using the ellipsoid formula measuring three perpendicular
tumor diameters. Tumor myometrial invasion was also analyzed.
Results. Higher MRI-TV was associated with age ≥ 65y, non-endometrioid tumors, grade-3, deep-myometrial invasion,
LN+ and advanced FIGO stage. There were 37 patients with LN+ (8.8%). Non-endometrioid tumors, deep-myometrial
invasion, grade-3 and MRI-TV ≥ 10 cm3 were the factors associated with LN+. Using a receiver operating characteristic
[ROC] curve, the MRI-TV cut-off for survival was 10 cm3 (area under curve [AUC] = 0.70; 95% CI: 0.61–0.73). 5 years
disease-free (DFS) and overall survival (OS) was significantly lower in MRI-TV ≥ 10 cm3 (69.3% vs. 84.5%, and 75.4% vs.
96.1%, respectively). MRI-TV was considered an independent factor of DFS (HR: 2.20, 95% CI: 1.09–4.45, p = 0.029) and
OS (HR: 3.88, 95% CI: 1.34–11.24, p = 0.012) in multivariate analysis.
Conclusions. MRI-TV was associated with LN+, and MRI-TV ≥ 10 cm3 was an independent prognostic factor of lower
DFS and OS. The MRI-TV can be auxiliary information to plan the surgery strategy and predict the adjuvant treatment
in women with endometrial cancer. | spa |
dc.language.iso | eng | spa |
dc.publisher | Radiology and Oncology | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Tumoral volume | spa |
dc.subject | Magnetic resonance image | spa |
dc.subject | Endometrial cancer | spa |
dc.subject | Recurrence | spa |
dc.subject | Survival | spa |
dc.title | Tumoral volume measured preoperatively by magnetic resonance imaging is related to survival in endometrial cancer. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dc.rights.accessRights | open access | spa |
dc.description.extent | 403 KB | spa |
dc.identifier.doi | 10.2478/raon-2020-0064 | spa |
dc.relation.publisherversion | https://www.sciendo.com/article/10.2478/raon-2020-0064 | spa |