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dc.contributor.authorCoronado, Pluvio
dc.contributor.authorDe Santiago López, Javier
dc.contributor.authorDe Santiago García, Javier
dc.contributor.authorMéndez, Ramiro
dc.contributor.authorFasero Laiz, María
dc.contributor.authorHerraiz, Miguel A.
dc.date.accessioned2022-02-22T12:34:32Z
dc.date.available2022-02-22T12:34:32Z
dc.date.issued2021
dc.identifier.issn1581-3207spa
dc.identifier.urihttp://hdl.handle.net/10641/2851
dc.description.abstractBackground. The aim of the study was to determine if the endometrial tumor volume (TV) measured by magnetic resonance imaging (MRI-TV) is associated with survival in endometrial cancer and lymph nodes metastases (LN+). Patients and methods. We evaluated the MRI imaging and records of 341 women with endometrial cancer and preoperative MRI from 2008 to 2018. The MRI-TV was calculated using the ellipsoid formula measuring three perpendicular tumor diameters. Tumor myometrial invasion was also analyzed. Results. Higher MRI-TV was associated with age ≥ 65y, non-endometrioid tumors, grade-3, deep-myometrial invasion, LN+ and advanced FIGO stage. There were 37 patients with LN+ (8.8%). Non-endometrioid tumors, deep-myometrial invasion, grade-3 and MRI-TV ≥ 10 cm3 were the factors associated with LN+. Using a receiver operating characteristic [ROC] curve, the MRI-TV cut-off for survival was 10 cm3 (area under curve [AUC] = 0.70; 95% CI: 0.61–0.73). 5 years disease-free (DFS) and overall survival (OS) was significantly lower in MRI-TV ≥ 10 cm3 (69.3% vs. 84.5%, and 75.4% vs. 96.1%, respectively). MRI-TV was considered an independent factor of DFS (HR: 2.20, 95% CI: 1.09–4.45, p = 0.029) and OS (HR: 3.88, 95% CI: 1.34–11.24, p = 0.012) in multivariate analysis. Conclusions. MRI-TV was associated with LN+, and MRI-TV ≥ 10 cm3 was an independent prognostic factor of lower DFS and OS. The MRI-TV can be auxiliary information to plan the surgery strategy and predict the adjuvant treatment in women with endometrial cancer.spa
dc.language.isoengspa
dc.publisherRadiology and Oncologyspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectTumoral volumespa
dc.subjectMagnetic resonance imagespa
dc.subjectEndometrial cancerspa
dc.subjectRecurrencespa
dc.subjectSurvivalspa
dc.titleTumoral volume measured preoperatively by magnetic resonance imaging is related to survival in endometrial cancer.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent403 KBspa
dc.identifier.doi10.2478/raon-2020-0064spa
dc.relation.publisherversionhttps://www.sciendo.com/article/10.2478/raon-2020-0064spa


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España