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dc.contributor.authorMartín Martínez, Yasmina 
dc.contributor.authorNegredo, Pilar
dc.contributor.authorAvendaño, Carlos
dc.date.accessioned2022-03-04T12:13:01Z
dc.date.available2022-03-04T12:13:01Z
dc.date.issued2021
dc.identifier.issn1863-2653spa
dc.identifier.urihttp://hdl.handle.net/10641/2884
dc.description.abstractNervous systems respond with structural changes to environmental changes even in adulthood. In recent years, experience-dependent structural plasticity was shown not to be restricted to the cerebral cortex, as it also occurs at subcortical and even peripheral levels. We have previously shown that two populations of trigeminal nuclei neurons, trigeminothalamic barrelette neurons of the principal nucleus (Pr5), and intersubnuclear neurons in the caudal division of the spinal trigeminal nucleus (Sp5C) that project to Pr5 underwent morphometric and topological changes in their dendritic trees after a prolonged total or partial loss of afferent input from the vibrissae. Here we examined whether and what structural alterations could be elicited in the dendritic trees of the same cell populations in young adult rats after being exposed for 2 months to an enriched environment (EE), and how these changes evolved when animals were returned to standard housing for an additional 2 months. Neurons were retrogradely labeled with BDA delivered to, respectively, the ventral posteromedial thalamic nucleus or Pr5. Fully labeled cells were digitally reconstructed with Neurolucida and analyzed with NeuroExplorer. EE gave rise to increases in dendritic length, number of trees and branching nodes, spatial expansion of the trees, and dendritic spines, which were less pronounced in Sp5C than in Pr5 and differed between sides. In Pr5, these parameters returned, but only partially, to control values after EE withdrawal. These results underscore a ubiquity of experience-dependent changes that should not be overlooked when interpreting neuroplasticity and developing plasticity-based therapeutic strategies.spa
dc.language.isoengspa
dc.publisherBrain Structure and Functionspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectDendritic treesspa
dc.subjectBarrelsspa
dc.subjectEnriched environmentspa
dc.subjectMorphometryspa
dc.subjectAdult brain plasticityspa
dc.subjectDextran aminespa
dc.titleExperience-dependent plasticity in early stations of sensory processing in mature brains: effects of environmental enrichment on dendrite measures in trigeminal nuclei.spa
dc.typejournal articlespa
dc.type.hasVersionAMspa
dc.rights.accessRightsopen accessspa
dc.description.extent2959 KBspa
dc.identifier.doi10.1007/s00429-021-02424-3spa
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00429-021-02424-3?utm_source=xmol&utm_medium=affiliate&utm_content=meta&utm_campaign=DDCN_1_GL01_metadata#citeasspa


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España