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dc.contributor.authorGonzález-Cantero, Álvaro
dc.contributor.authorTeklu, Meron
dc.contributor.authorSorokin, Alexander V
dc.contributor.authorPrussick, Ronald
dc.contributor.authorGonzález-Cantero, Jorge
dc.contributor.authorMartin- Rodriguez, Jose Luis
dc.contributor.authorPatel, Nidhi
dc.contributor.authorParel, Philip M
dc.contributor.authorManyak, Grigory A
dc.contributor.authorTeague, Heather L
dc.contributor.authorRodante, Justin A
dc.contributor.authorKeel, Andrew
dc.contributor.authorPérez-Hortet, Cristina
dc.contributor.authorSanchéz-Moya, Ana I
dc.contributor.authorJiménez, Natalia
dc.contributor.authorBallester, Asunción
dc.contributor.authorSolis, Jorge
dc.contributor.authorFernandez-Friera, Leticia
dc.contributor.authorBarderas, María G
dc.contributor.authorGonzalez-Calvin, Jorge L
dc.contributor.authorJaen, Pedro
dc.contributor.authorPlayford, Martin P
dc.contributor.authorDey, Amit K
dc.contributor.authorGelfand, Joel M
dc.contributor.authorMehta, Nehal N
dc.description.abstractPsoriasis is associated with a higher risk of liver diseases. We investigated the impact of hepatic steatosis (European cohort) and hepatic inflammation (United States cohort) on subclinical atherosclerosis. In the European cohort (n = 76 psoriasis participants and 76 controls), nonalcoholic fatty liver disease, assessed by the sonographic hepatorenal index, was more prevalent in psoriasis than in controls (61% vs. 45%; P = 0.04). Participants with psoriasis with nonalcoholic fatty liver disease had a higher prevalence of subclinical atherosclerosis (ultrasonographic presence of plaque in femoral or carotid arteries) than participants with psoriasis without nonalcoholic fatty liver disease (61% vs. 23%; P = 0.006) and controls with nonalcoholic fatty liver disease (61% vs. 32%; P < 0.05). Sonographic hepatorenal index was a determinant of subclinical atherosclerosis in psoriasis (OR = 3.5; P = 0.01). In the United States cohort (n = 162 participants with psoriasis who underwent positron emission tomography and coronary computed tomography angiography), those with high hepatic 2-[fluorine-18]fluoro-2-deoxy-D-glucose uptake had higher noncalcified (1.3 [0.49 mm2] vs. 1.0 [0.40 mm2]), fibrofatty (0.23 [0.15 mm2] vs. 0.11 [0.087 mm2]), and lipid-rich necrotic core (4.3 [2.3 mm2] vs. 3.0 [1.7 mm2]) coronary burden (all P < 0.001). Hepatic 2-[fluorine-18]fluoro-2-deoxy-D-glucose uptake associated with noncalcified (β = 0.28; P < 0.001), fibrofatty (β = 0.49; P < 0.001), and lipid-rich necrotic core (β = 0.28; P = 0.003) burden. These results show the downstream cardiovascular effects of subclinical liver disease in
dc.publisherJournal of Investigative Dermatologyspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.titleSubclinical Liver Disease Is Associated with Subclinical Atherosclerosis in Psoriasis: Results from Two Observational
dc.description.extent723 KBspa

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