Advances of Genomic Medicine in Psoriatic Arthritis.
Author: Laborde, Carlos M.; Larzabal, Leyre; González-Cantero, Álvaro; Castro-Santos, Patricia; Díaz-Peña, Roberto
Abstract: Psoriatic arthritis (PsA) is a common type of inflammatory arthritis found in up to 40% of
patients with psoriasis. Although early diagnosis is important for reducing the risk of irreversible
structural damage, there are no adequate screening tools for this purpose, and there are no clear
markers of predisposition to the disease. Much evidence indicates that PsA disorder is complex and
heterogeneous, where genetic and environmental factors converge to trigger inflammatory events
and the development of the disease. Nevertheless, the etiologic events that underlie PsA are complex
and not completely understood. In this review, we describe the existing data in PsA in order to
highlight the need for further research in this disease to progress in the knowledge of its pathobiology
and to obtain early diagnosis tools for these patients.
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