dc.contributor.author | Tamayo, María | |
dc.contributor.author | Martín Nunes, Laura | |
dc.contributor.author | Garcia Miguel Piedras, María José | |
dc.contributor.author | Martín Calvo, María | |
dc.contributor.author | Martí Morente, Daniel | |
dc.contributor.author | Gil Fernández, Marta | |
dc.contributor.author | Gómez Hurtado, Nieves | |
dc.contributor.author | Moro, María Ángeles | |
dc.contributor.author | Bosca, Lisardo | |
dc.contributor.author | Fernández Velasco, María | |
dc.contributor.author | Delgado, Carmen | |
dc.date.accessioned | 2022-06-09T10:40:14Z | |
dc.date.available | 2022-06-09T10:40:14Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1422-0067 | spa |
dc.identifier.uri | http://hdl.handle.net/10641/2998 | |
dc.description.abstract | Adverse ventricular remodeling is the heart’s response to damaging stimuli and is linked to
heart failure and poor prognosis. Formyl-indolo [3,2-b] carbazole (FICZ) is an endogenous ligand for
the aryl hydrocarbon receptor (AhR), through which it exerts pleiotropic effects including protection
against inflammation, fibrosis, and oxidative stress. We evaluated the effect of AhR activation by
FICZ on the adverse ventricular remodeling that occurs in the early phase of pressure overload in
the murine heart induced by transverse aortic constriction (TAC). Cardiac structure and function
were evaluated by cardiac magnetic resonance imaging (CMRI) before and 3 days after Sham or TAC
surgery in mice treated with FICZ or with vehicle, and cardiac tissue was used for biochemical studies.
CMRI analysis revealed that FICZ improved cardiac function and attenuated cardiac hypertrophy.
These beneficial effects involved the inhibition of the hypertrophic calcineurin/NFAT pathway,
transcriptional reduction in pro-fibrotic genes, and antioxidant effects mediated by the NRF2/NQO1
pathway. Overall, our findings provide new insight into the role of cardiac AhR signaling in the
injured heart. | spa |
dc.language.iso | eng | spa |
dc.publisher | International Journal of Molecular Sciences | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Aryl hydrocarbon receptor | spa |
dc.subject | Fibrosis | spa |
dc.subject | Cardiac hypertrophy | spa |
dc.subject | Oxidative stress | spa |
dc.subject | Cardiac remodeling | spa |
dc.subject | Formyl-indolo | spa |
dc.subject | Carbazole | spa |
dc.title | The Aryl Hydrocarbon Receptor Ligand FICZ Improves Left Ventricular Remodeling and Cardiac Function at the Onset of Pressure Overload-Induced Heart Failure in Mice. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | SMUR | spa |
dc.rights.accessRights | open access | spa |
dc.description.extent | 3293 KB | spa |
dc.identifier.doi | 10.3390/ijms23105403 | spa |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/23/10/5403 | spa |