dc.contributor.author | Tesoro Santos, Laura | |
dc.contributor.author | Hernández, Ignacio | |
dc.contributor.author | Ramírez Carracedo, Rafael | |
dc.contributor.author | Díez-Mata, Javier | |
dc.contributor.author | Alcharani, Nunzio | |
dc.contributor.author | Jiménez-Guirado, Beatriz | |
dc.contributor.author | Ovejero-Paredes, Karina | |
dc.contributor.author | Filice, Marco | |
dc.contributor.author | Zamorano, Jose Luis | |
dc.contributor.author | Saura, Marta | |
dc.contributor.author | Zaragoza Sánchez, Carlos | |
dc.contributor.author | Botana, Laura | |
dc.date.accessioned | 2022-12-12T13:02:32Z | |
dc.date.available | 2022-12-12T13:02:32Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1999-4923 | spa |
dc.identifier.uri | https://hdl.handle.net/10641/3190 | |
dc.description.abstract | Background: Early response after acute myocardial infarction (AMI) prevents extensive
cardiac necrosis, in which inflammation resolution, including expression of anti-inflammatory
interleukin-10 (IL-10), may play a key role. (2) Methods: We synthesized NIL10, a micelle-based
nanoparticle, to target IL-10 receptor in mice and pigs subjected to AMI. (3) Results: Administration
of NIL10 induced cardiac protection of wild-type and IL-10 knockout mice and pigs subjected to AMI.
Cardiac protection was not induced in IL-10-receptor null mice, as shown by a significant recovery of
cardiac function, in which inflammatory foci and fibrosis were strongly reduced, together with the
finding that resolving M2-like macrophage populations were increased after day 3 of reperfusion. In
addition, anti-inflammatory cytokines, including IL-4, IL-7, IL-10, IL-13, IL-16, and IL-27 were also
elevated. Mechanistically, NIL10 induced activation of the IL-10 receptor/STAT-3 signaling pathway,
and STAT3-dependent inhibition of nuclear translocation of pro-inflammatory NF-kB transcription
factor. (4) Conclusions: Taken together, we propose using NIL10 as a novel therapeutic tool against
AMI-induced cardiac damage | spa |
dc.language.iso | eng | spa |
dc.publisher | Pharmaceutics | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Acute myocardial infarction | spa |
dc.subject | Interleukin-10 | spa |
dc.subject | Nanoparticles | spa |
dc.title | NIL10: A New IL10-Receptor Binding Nanoparticle That Induces Cardiac Protection in Mice and Pigs Subjected to Acute Myocardial Infarction through STAT3/NF-kB Activation. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dc.rights.accessRights | open access | spa |
dc.description.extent | 4711 KB | spa |
dc.identifier.doi | 10.3390/pharmaceutics14102044 | spa |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/14/10/2044 | spa |