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dc.contributor.authorTesoro Santos, Laura 
dc.contributor.authorHernández, Ignacio
dc.contributor.authorRamírez Carracedo, Rafael
dc.contributor.authorDíez-Mata, Javier
dc.contributor.authorAlcharani, Nunzio
dc.contributor.authorJiménez-Guirado, Beatriz
dc.contributor.authorOvejero-Paredes, Karina
dc.contributor.authorFilice, Marco
dc.contributor.authorZamorano, Jose Luis
dc.contributor.authorSaura, Marta
dc.contributor.authorZaragoza Sánchez, Carlos 
dc.contributor.authorBotana, Laura
dc.date.accessioned2022-12-12T13:02:32Z
dc.date.available2022-12-12T13:02:32Z
dc.date.issued2022
dc.identifier.issn1999-4923spa
dc.identifier.urihttps://hdl.handle.net/10641/3190
dc.description.abstractBackground: Early response after acute myocardial infarction (AMI) prevents extensive cardiac necrosis, in which inflammation resolution, including expression of anti-inflammatory interleukin-10 (IL-10), may play a key role. (2) Methods: We synthesized NIL10, a micelle-based nanoparticle, to target IL-10 receptor in mice and pigs subjected to AMI. (3) Results: Administration of NIL10 induced cardiac protection of wild-type and IL-10 knockout mice and pigs subjected to AMI. Cardiac protection was not induced in IL-10-receptor null mice, as shown by a significant recovery of cardiac function, in which inflammatory foci and fibrosis were strongly reduced, together with the finding that resolving M2-like macrophage populations were increased after day 3 of reperfusion. In addition, anti-inflammatory cytokines, including IL-4, IL-7, IL-10, IL-13, IL-16, and IL-27 were also elevated. Mechanistically, NIL10 induced activation of the IL-10 receptor/STAT-3 signaling pathway, and STAT3-dependent inhibition of nuclear translocation of pro-inflammatory NF-kB transcription factor. (4) Conclusions: Taken together, we propose using NIL10 as a novel therapeutic tool against AMI-induced cardiac damagespa
dc.language.isoengspa
dc.publisherPharmaceuticsspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectAcute myocardial infarctionspa
dc.subjectInterleukin-10spa
dc.subjectNanoparticlesspa
dc.titleNIL10: A New IL10-Receptor Binding Nanoparticle That Induces Cardiac Protection in Mice and Pigs Subjected to Acute Myocardial Infarction through STAT3/NF-kB Activation.spa
dc.typejournal articlespa
dc.type.hasVersionAMspa
dc.rights.accessRightsopen accessspa
dc.description.extent4711 KBspa
dc.identifier.doi10.3390/pharmaceutics14102044spa
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/14/10/2044spa


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España