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dc.contributor.authorFernández-Gallego, Nieves
dc.contributor.authorJiménez-Saiz, Rodrigo
dc.date.accessioned2023-04-03T11:40:23Z
dc.date.available2023-04-03T11:40:23Z
dc.date.issued2022
dc.identifier.issn0105-4538spa
dc.identifier.urihttps://hdl.handle.net/10641/3323
dc.description.abstractAllergic diseases are allergen-induced immunological disorders characterized by the development of type 2 immunity and IgE responses. The prevalence of allergic diseases has been on the rise alike cardiovascular disease (CVD), which affects arteries of different organs such as the heart, the kidney and the brain. The underlying cause of CVD is often atherosclerosis, a disease distinguished by endothelial dysfunction, fibrofatty material accumulation in the intima of the artery wall, smooth muscle cell proliferation, and Th1 inflammation. The opposed T-cell identity of allergy and atherosclerosis implies an atheroprotective role for Th2 cells by counteracting Th1 responses. Yet, the clinical association between allergic disease and CVD argues against it. Within, we review different phases of allergic pathology, basic immunological mechanisms of atherosclerosis and the clinical association between allergic diseases (particularly asthma, atopic dermatitis, allergic rhinitis and food allergy) and CVD. Then, we discuss putative atherogenic mechanisms of type 2 immunity and allergic inflammation including acute allergic reactions (IgE, IgG1, mast cells, macrophages and allergic mediators such as vasoactive components, growth factors and those derived from the complement, contact and coagulation systems) and late phase inflammation (Th2 cells, eosinophils, type 2 innate-like lymphoid cells, alarmins, IL-4, IL-5, IL-9, IL-13 and IL-17).spa
dc.language.isoengspa
dc.publisherAllergyspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectAllergic inflammationspa
dc.subjectAtherogenesisspa
dc.subjectAtherosclerosisspa
dc.subjectCardiovascular diseasespa
dc.subjectType 2 immunityspa
dc.titleThe impact of type 2 immunity and allergic diseases in atherosclerosis.spa
dc.typejournal articlespa
dc.type.hasVersionAMspa
dc.rights.accessRightsopen accessspa
dc.description.extent4164 KBspa
dc.identifier.doi10.1111/all.15426spa
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/all.15426spa


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España