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dc.contributor.authorTavares, Diana
dc.contributor.authorMouriño, Helena
dc.contributor.authorAntón Rodríguez, Cristina 
dc.contributor.authorMartín Saborido, Carlos 
dc.date.accessioned2023-04-11T12:08:26Z
dc.date.available2023-04-11T12:08:26Z
dc.date.issued2022
dc.identifier.issn2076-393Xspa
dc.identifier.urihttps://hdl.handle.net/10641/3340
dc.description.abstractBackground: quadrivalent inactivated vaccine (QIV) has replaced trivalent inactivated vaccine (TIV). In Portugal, TIV is free of charge for risk groups, including older adults (≥65 years old). In its turn, QIV—which provides broader protection as it includes an additional lineage B strain—was introduced in Portugal in October 2018; only since the 2019/20 influenza season has it been provided free of charge for risk groups. This study evaluates the cost effectiveness of switching from TIV to QIV, from the National Health Service perspective, in the Portuguese elderly mainland population. Methods: A decision tree model was developed to compare TIV and QIV, based on Portuguese hospitalization data for the 2015/16 influenza season. The primary health economic outcome under consideration was the incremental cost-effectiveness ratio (ICER). In addition, one-way sensitivity analysis and probabilistic sensitivity analysis were performed. Results: the high cost of QIV (approximately three times the cost of TIV) would lead to a total increment of EUR 5,283,047, and the resulting ICER would be EUR 26,403,007/QALY, above the usual willingness-to-pay threshold. Conclusions: from the National Health Service perspective, our findings reveal that QIV is not cost effective for the Portuguese elderly population due to the high cost. If the QIV costs were the same as the TIV, then QIV would be cost effective.spa
dc.language.isoengspa
dc.publisherVaccinesspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectInfluenza vaccinesspa
dc.subjectDecision treespa
dc.subjectCost effectiveness analysisspa
dc.subjectOne-way sensitivity analysisspa
dc.subjectProbabilistic sensitivity analysisspa
dc.titleCost Effectiveness of Quadrivalent Versus Trivalent Inactivated Influenza Vaccines for the Portuguese Elderly Population.spa
dc.typejournal articlespa
dc.type.hasVersionAMspa
dc.rights.accessRightsopen accessspa
dc.description.extent1177 KBspa
dc.identifier.doi10.3390/vaccines10081285spa
dc.relation.publisherversionhttps://www.mdpi.com/2076-393X/10/8/1285spa


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España