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An Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points From the (TCAMS)

dc.contributor.authorCalderón, Félix
dc.contributor.authorBarros, David
dc.contributor.authorLeón Díaz, María Luisa
dc.contributor.authorCastro, Julia
dc.date.accessioned2023-12-22T11:43:02Z
dc.date.available2023-12-22T11:43:02Z
dc.date.issued2011
dc.identifier.issn1948-5875spa
dc.identifier.urihttps://hdl.handle.net/10641/3614
dc.description.abstractIn 2010, GlaxoSmithKline published the structures of 13533 chemical starting points for antimalarial lead identification. By using an agglomerative structural clustering technique followed by computational filters such as antimalarial activity, physicochemical properties, and dissimilarity to known antimalarial structures, we have identified 47 starting points for lead optimization. Their structures are provided. We invite potential collaborators to work with us to discover new clinical candidates.spa
dc.language.isoengspa
dc.publisherACS Medicinal Chemistry Lettersspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectMalariaspa
dc.subjectLead optimizationspa
dc.subjectOpen innovationspa
dc.titleAn Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points From the (TCAMS)spa
dc.typejournal articlespa
dc.type.hasVersionSMURspa
dc.rights.accessRightsopen accessspa
dc.description.extent294 KBspa
dc.identifier.doi10.1021/ml200135pspa
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/ml200135pspa


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