A systematic review and meta-analysis on the efficacy of topical povidone iodine in adenoviral conjunctivitis.
Autor: González Martín-Moro, Julio; Zarallo Gallardo, J.; Guzmán Almagro, Elena; Antón Rodríguez, Cristina
Resumen: Purpose: To evaluate if topical povidone iodine (alone (PI) or combined with dexamethasone (PI-DXM)) is superior
to placebo for treating adenoviral conjunctivitis (AC).
Methods: A systematic review was performed according to Preferred Reporting Items for the Systematic Review
and Meta-Analyses (PRISMA) Statement. An electronic search was made of PubMed, Embase and
Cochrane Library. Randomized control studies that compared PI or PI-DXM with placebo were included. At
least three researchers were involved in all phases. Primary outcomes were AC duration and the number of
clinical resolutions during the first week. Secondary outcomes were conjunctival redness and serous discharge
one week after starting treatment and the rate of AC complications.
Results: Only five studies met the inclusion criteria. PI-DXM reduced the duration of the disease by 2.4 days
(IC95% 4.09–0.71), however this result was based only in one study. PI and PI-DXM did not modify the probability
of clinical resolution during the first week; relative risk (RR) = 1.77 (IC95% 0.63–4.96) and 1.70 (IC95%
0.67–4.36). The impact of PI on the probability of pseudomembranes could not be estimated. PI-DXM did not influence
the risk of developing subepithelial infiltrates RR = 0.73 (IC95% 0.02–3.38).
Conclusions: At this time there is great uncertainty about the usefulness of PI on the course of adenoviral conjunctivitis.
PI-DXM may have a small effect on AC duration. To make future reviews possible, it is important to
standardize the way in which these results are reported. Futures studies should include etiological confirmation,
unit of study (eyes vs patients) and report on those aspects that are more relevant for patient quality of life (duration
of the disease, development of complications: pseudomembranes and subepithelial infiltrates).
Identificador universal: https://hdl.handle.net/10641/3629
Fecha: 2023
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