dc.contributor.author | Rodríguez Socarrás, Moises Elias | |
dc.contributor.author | Cuadros Rivera, Vanesa | |
dc.contributor.author | Reinoso Elbers, Javier | |
dc.contributor.author | Llanes González, Luis | |
dc.contributor.author | Michel Mercado, Ivan | |
dc.contributor.author | Gomez Rivas, Juan | |
dc.contributor.author | Fernandez Del Alamo, Julio | |
dc.contributor.author | Juarez Del Dago, Pablo | |
dc.contributor.author | Gomez Sancha, Fernando | |
dc.date.accessioned | 2024-01-05T11:53:36Z | |
dc.date.available | 2024-01-05T11:53:36Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0022-5347 | spa |
dc.identifier.uri | https://hdl.handle.net/10641/3651 | |
dc.description.abstract | Purpose:
We assessed the prostate cancer detection accuracy of transperineal prostate biopsy using multiparametric magnetic resonance imaging/ultrasound fusion targeted biopsy and micro-ultrasound during the same procedure. Micro-ultrasound is a new high-resolution imaging system that allows real-time targeted biopsy.
Materials and Methods:
A total of 194 consecutive patients underwent transperineal prostate biopsies using real-time targeted micro-ultrasound (ExactVu™) and ultrasound fusion targeted biopsy (BiopSee®) in the same procedure, from February 2018 to September 2019. Biopsies were performed using a transperineal needle guide attached to the 29 MHz high-resolution micro-ultrasound transducer.
Results:
The overall positive rate was 56% (108) for prostate cancer and 42% (81) for clinically significant prostate cancer (Gleason Grade Group greater than 1), and adding micro-ultrasound and magnetic resonance imaging detected significantly more clinically significant prostate cancer than systematic biopsy (p <0.001). Micro-ultrasound found 12 of 108 (11%) prostate cancers that were missed by all other techniques and 11 (92%) were clinically significant prostate cancer. PI-RADS® and PRI-MUS™ (Prostate Risk Identification Using Micro-Ultrasound) were strong predictors of clinically significant prostate cancer in a logistic regression model (AUC 0.76). For prostate specific antigen greater than 4 ng/ml, PI-RADS greater than 3, there was an improvement in detection rate between PRI-MUS 4 and PRI-MUS 5 (52% Gleason Grade Group greater than 1 to 92% Gleason Grade Group greater than 1). No fever or clinical infection was observed and 17 (8.7%) patients presented with minor complications (Clavien Dindo I).
Conclusions:
This is the first study using a transperineal approach for micro-ultrasound guided biopsy and multiparametric magnetic resonance imaging fusion biopsy. The results show a high accuracy for prostate cancer and clinically significant prostate cancer diagnosis, without infectious complications. The proposed method should be validated in large randomized clinical trials. | spa |
dc.language.iso | eng | spa |
dc.publisher | The Journal of Urology | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.title | Prostate Mapping for Cancer Diagnosis: The Madrid Protocol. Transperineal Prostate Biopsies Using Multiparametric Magnetic Resonance Imaging Fusion and Micro-Ultrasound Guided Biopsies. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dc.rights.accessRights | open access | spa |
dc.description.extent | 2,39 MB | spa |
dc.identifier.doi | 10.1097/JU.0000000000001083 | spa |
dc.relation.publisherversion | https://www.auajournals.org/doi/epdf/10.1097/JU.0000000000001083 | spa |