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dc.contributor.authorBouthelier, Antonio
dc.contributor.authorFernández-Arroyo, Lucía
dc.contributor.authorMesa-Ciller, Claudia
dc.contributor.authorCibrian, Danay
dc.contributor.authorMartín-Cófreces, Noa Beatriz
dc.contributor.authorCastillo-González, Raquel
dc.contributor.authorCalero, Macarena
dc.contributor.authorHerráez Aguilar, Diego
dc.contributor.authorGuajardo-Grence, Andrea
dc.contributor.authorPacheco, Ana María
dc.contributor.authorMarcos-Jiménez, Ana
dc.contributor.authorQuiroga, Borja
dc.contributor.authorMorado, Marta
dc.contributor.authorMonroy, Francisco
dc.contributor.authorMuñoz-Calleja, Cecilia
dc.contributor.authorSánchez-Madrid, Francisco
dc.contributor.authorUrrutia, Andrés A.
dc.contributor.authorAragonés, Julián
dc.description.abstractInhibition of the heterodimeric amino acid carrier SLC7A5/SLC3A2 (LAT1/CD98) has been widely studied in tumor biology but its role in physiological conditions remains largely unknown. Here we show that the SLC7A5/SLC3A2 heterodimer is constitutively present at different stages of erythroid differentiation but absent in mature erythrocytes. Administration of erythropoietin (EPO) further induces SLC7A5/SLC3A2 expression in circulating reticulocytes, as it also occurs in anemic conditions. Although Slc7a5 gene inactivation in the erythrocyte lineage does not compromise the total number of circulating red blood cells (RBCs), their size and hemoglobin content are significantly reduced accompanied by a diminished erythroblast mTORC1 activity. Furthermore circulating Slc7a5-deficient reticulocytes are characterized by lower transferrin receptor (CD71) expression as well as mitochondrial activity, suggesting a premature transition to mature RBCs. These data reveal that SLC7A5/SLC3A2 ensures adequate maturation of reticulocytes as well as the proper size and hemoglobin content of circulating
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.titleErythroid SLC7A5/SLC3A2 amino acid carrier controls red blood cell size and
dc.typejournal articlespa
dc.rights.accessRightsopen accessspa
dc.description.extent3,49 MBspa

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España