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Intratympanic infliximab is a safe and effective rescue therapy for refractory immune-mediated hearing loss.
dc.contributor.author | Mata Castro, Nieves | |
dc.contributor.author | Sanz López, Lorena | |
dc.contributor.author | Varillas Delgado, David | |
dc.contributor.author | García Fernández, Alfredo | |
dc.date.accessioned | 2024-02-09T10:11:33Z | |
dc.date.available | 2024-02-09T10:11:33Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0937-4477 | spa |
dc.identifier.uri | https://hdl.handle.net/10641/3926 | |
dc.description.abstract | Purpose To determine the efficacy and safety of the intratympanic infiltration of infliximab at the hearing threshold of patients in follow-up for refractory immune-mediated hearing loss. Methods 17 patients were collected with relapses, despite maintenance treatment with oral azathioprine associated or not with oral prednisone at low doses (between 5 and 7.5 ml/day) or refractory relapses to previous intratympanic corticoid treatment being 19 affected ears infiltrated. We measured the hearing threshold by Pure-Tone Average (PTA) 500–3000 Hz, 125–8000 Hz and 250–8000 Hz in pre-infiltration (baseline) and follow-up 3 weeks post-infiltration with auditory threshold at frequencies 125–8000 Hz. Results The average age was 50.68 years (±15.23 years). After the administration of intratympanic infliximab, an improvement of the hearing threshold was showed in the Pure-Tone Average (PTA) calculated at 500–3000 Hz (p = 0.004), 125–8000 Hz (p = 0.001) and 250–8000 Hz (p = 0.006). An immediate improvement in low frequencies also was observed: 125, 250 and 500 Hz (p = 0.009, p = 0.002 and p < 0.001 respectively) also at 1000 Hz (p = 0.004) and a persistence of the effect at 3 months in the low frequencies: 125 Hz (p = 0.020), 250 Hz (p = 0.006) and 500 Hz (p = 0.002). Conclusions Infliximab intratympanic infiltration improves the hearing threshold in patients with immune-mediated hearing loss. The effect of improving the hearing threshold is higher in low frequencies and persists within 3 months of the infiltration. The administration of intratympanic infliximab is an effective and safe technique. | spa |
dc.language.iso | eng | spa |
dc.publisher | European Archives of Oto-Rhino-Laryngology | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.title | Intratympanic infliximab is a safe and effective rescue therapy for refractory immune-mediated hearing loss. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dc.rights.accessRights | metadata only access | spa |
dc.identifier.doi | 10.1007/s00405-019-05716-x | spa |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s00405-019-05716-x | spa |
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