dc.contributor.author | Berg, Alexander R. | |
dc.contributor.author | Petrole, Rylee F. | |
dc.contributor.author | Li, Haiou | |
dc.contributor.author | Sorokin, Alexander V. | |
dc.contributor.author | González-Cantero, Álvaro | |
dc.contributor.author | Playford, Martin P. | |
dc.contributor.author | Mehta, Nehal N. | |
dc.contributor.author | Teague, Heather L. | |
dc.date.accessioned | 2024-03-02T10:05:26Z | |
dc.date.available | 2024-03-02T10:05:26Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2297-055X | spa |
dc.identifier.uri | https://hdl.handle.net/10641/4212 | |
dc.description.abstract | Background and objective: Psoriasis is a systemic inflammatory condition with poor cholesterol transport measured by cholesterol efflux capacity (CEC) that is associated with a heightened risk of cardiovascular disease (CVD). In psoriasis patients, we sought to characterize the lipoprotein profile by size using a novel nuclear magnetic resonance algorithm in patients with low CEC compared to normal CEC.
Methods: Lipoprotein profile was assessed using the novel nuclear magnetic resonance LipoProfile-4 deconvolution algorithm. Aortic vascular inflammation (VI) and non-calcified burden (NCB) were characterized via positron emission tomography-computed tomography and coronary computed tomography angiography. To understand the relationship between lipoprotein size and markers of subclinical atherosclerosis, linear regression models controlling for confounders were constructed.
Results: Psoriasis patients with low CEC had higher more severe psoriasis (p = 0.04), VI (p = 0.04) and NCB (p = 0.001), concomitant with smaller high-density lipoprotein (HDL) (p < 0.001) and low-density lipoprotein (LDL) particles (p < 0.001). In adjusted models HDL size (β = −0.19; p = 0.02) and LDL size (β = −0.31; p < 0.001) associated with VI and NCB. Lastly, HDL size strongly associated with LDL size in fully adjusted models (β = −0.27; p < 0.001).
Conclusion: These findings demonstrate that in psoriasis, low CEC associates with a lipoprotein profile comprised of smaller HDL and LDL particles which correlates with vascular health and may be driving early onset atherogenesis. Further, these results demonstrate a relationship between HDL and LDL size and provide novel insights into the complexities of HDL and LDL as biomarkers of vascular health. | spa |
dc.language.iso | eng | spa |
dc.publisher | Frontiers in Cardiovascular Medicine | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Psoriasis | spa |
dc.subject | Cholesterol efflux | spa |
dc.subject | High density lipoprotein | spa |
dc.subject | Low density lipoprotein | spa |
dc.subject | Lipoprotein size | spa |
dc.subject | Atheroscelrosis | spa |
dc.title | Cholesterol efflux capacity is associated with lipoprotein size and vascular health in mild to moderate psoriasis. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | SMUR | spa |
dc.rights.accessRights | open access | spa |
dc.description.extent | 1259 KB | spa |
dc.identifier.doi | 10.3389/fcvm.2023.1041457 | spa |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1041457/full | spa |