2024-03-28T11:58:35Zhttp://ddfv.ufv.es/oai/requestoai:ddfv.ufv.es:10641/33222023-04-04T00:00:13Zcom_10641_132col_10641_1428
Project-Based Learning (PBL) and Its Impact on the Development of Interpersonal Competences in Higher Education.
Crespí, Paula
García Ramos, José Manuel
Queiruga Dios, Marián
Active learning
Higher educarion
In response to globalisation, and the cultural, socio-economic, and educational
changes it implies, higher education must offer a comprehensive education that
favours personal and professional growth. To do this, it must promote
competence-based learning through active teaching methodologies. This study will
analyse the use of Project-Based Learning (PBL) methodologies in the context of
transversal subjects, as an efficient technique to develop interpersonal
communication and teamworking skills. This research is quasi-experimental, with a
pre-test/post-test design with an equivalent control group. The sample consists of
610 university students from the Community of Madrid, of whom 387 participated
in the PBL (Experimental Group: EG) and 223 did not (Control Group: CG). A
reliable and validated questionnaire on personal competences was used as a
measurement instrument. The hypotheses on the effectiveness of PBL as a technique
for the development of interpersonal communication and teamworking skills in the
context of transversal subjects are confirmed. The results suggest that greater use of
active methodologies to promote the development of transversal or generic
competences is highly recommended and that the insertion of transversal subjects
into university curricula may be highly beneficial.
post-print
359 KB
2023-04-03T11:32:36Z
2023-04-03T11:32:36Z
2022
article
2254-7339
https://hdl.handle.net/10641/3322
10.7821/naer.2022.7.993
eng
https://naerjournal.ua.es/article/view/v11n2-6
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Journal of New Approaches in Educational Research
oai:ddfv.ufv.es:10641/34892023-11-03T01:00:09Zcom_10641_132col_10641_1421
WorldWide Observatory for Attractive Cities.
Ondiviela García, José Antonio
pre-print
5757 KB
2023-11-02T08:48:49Z
2023-11-02T08:48:49Z
2023
article
https://hdl.handle.net/10641/3489
eng
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Universidad Francisco de Vitoria
oai:ddfv.ufv.es:10641/10012019-09-26T13:26:48Zcom_10641_132col_10641_1423oai:ddfv.ufv.es:10641/25702023-11-02T12:13:22Zcom_10641_132col_10641_1438
An International Consensus List of Potentially Clinically Significant Drug-Drug Interactions in Older People.
Anrys, Pauline
Petit, Anne-Elisabeth
Thevelin, Stefanie
Sallevelt, Bastiaan
Drenth, Clara
Soiza, Roy L.
Correa Pérez, Andrea
Dalleur, Olivia
Spinewine, Anne
Delphi technique
Drug interactions
Aged
Objectives
We aimed to establish an explicit list of potentially clinically significant drug-drug interactions (DDIs) in people aged ≥65 years.
Design
A preliminary list of potentially clinically significant DDIs was compiled, based on 154 DDIs identified from literature review. Subsequently, a 2-round online Delphi survey was undertaken with a multidisciplinary expert panel. A consensus meeting and a final round were conducted to validate the final DDI list and the scope of information provided.
Setting and Participants
Twenty nine experts, including geriatricians and clinical pharmacists from 8 European countries.
Measures
For each DDI, in the first 2 rounds, experts were asked to score the severity of potential harm on a 5-point Likert-type scale. DDIs were directly included on the final list if the median score was 4 (major) or 5 (catastrophic). DDIs with a median score of 3 (moderate) were discussed at a consensus meeting and included if ≥75% of participants voted for inclusion in the final round.
Results
Consensus was achieved on 66 potentially clinically significant DDIs (28 had a median score of 4/5 and 48 of 3 in the Delphi survey). Most concerned cardiovascular, antithrombotic, and central nervous system drugs. The final list includes information on the mechanism of interaction, harm, and management. Treatment modification is recommended for three-quarters of DDIs.
Conclusion and Implications
We validated a list of potentially clinically significant DDIs in older people, which can be used in clinical practice and education to support identification and management of DDIs or to assess prevalence in epidemiologic and intervention studies.
pre-print
896 KB
2021-11-04T09:18:50Z
2021-11-04T09:18:50Z
2021
article
1525-8610
http://hdl.handle.net/10641/2570
10.1016/j.jamda.2021.03.019
eng
https://www.sciencedirect.com/science/article/pii/S1525861021003157?via%3Dihub#!
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Journal of the American Medical Directors Association
oai:ddfv.ufv.es:10641/21042021-02-04T09:29:32Zcom_10641_252col_10641_1446
Teoría mimética y educación sexual. Contra los géneros en conflicto.
Reyero, David
El trabajo pretende analizar el concepto de género y sus implicaciones para la teoría de la educación. Nos vamos haciendo en un proceso mimético también en lo referido a la sexualidad. Las teorías de género entienden todo marco referido a la sexualidad como construcción que podemos poner en disputa. Frente a estas teorías resisten modelos apoyados en la sexualidad binaria y la complementariedad. Ofrecer argumentos que permitan defender la razonabilidad de estos modelos es el objetivo de este trabajo.
post-print
2020-11-18T09:22:51Z
2020-11-18T09:22:51Z
2020
article
2603-6088
http://hdl.handle.net/10641/2104
10.32466/eufv-xg.2020.3.635.121-138
spa
https://portalderevistas.ufv.es/index.php/xgladius/article/view/635
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Universidad Francisco de Vitoria
oai:ddfv.ufv.es:10641/10482019-07-23T16:27:11Zcom_10641_252col_10641_1445
John Henry Newman on faith and reason
Briel, Don J.
Asentimiento
Fe
Razón
Cristianismo
The author explains how, in contrast with the risk “of the twin reduction of faith to a mere
emotive principle and reason to a mechanical exercise”, Newman seeks to re-define and
widen the concepts of reason and philosophy, so that, free from rationalism, philosophy
and reason can again give sense to one’s lived experience. A reason so widened by the
“experience of life” and by a living heart will be much more able to welcome a faith which
is given to it not as a right, or as syllogism, or as a burden, but as gift of love. Thus, faith
is no longer seen as something irrational, distant, accidental, as if it were a simple “private
preference”. Instead, it becomes a very reasonable and warm impulse that changes
man’s perspective over his existence and his Christian commitment, and transfigures
him towards a life of holiness.
El autor explica cómo, en contraste con el riesgo de reducir la fe a una “emoción” y la
razón a un “ejercicio mecánico”, Newman propone redefinir y ampliar los conceptos de
razón y de filosofía para que, liberadas del racionalismo, puedan volver a dar sentido a la
vida real. Una razón así ampliada con “experiencias de vida” y con un corazón palpitante
será mucho más capaz de acoger una fe que le es ofrecida no como un derecho, un silogismo
o una carga, sino como un don de amor. En consecuencia, la fe deja de percibirse
como algo irracional, ajeno y accesorio “como un gusto personal”, y se convierte en un
impulso auténticamente razonable y cordial que cambia la mirada del hombre sobre la
existencia y el cristianismo y transfigura su vida en santidad.
El autor explica cómo, en contraste con el riesgo de reducir la fe a una “emoción” y la
razón a un “ejercicio mecánico”, Newman propone redefinir y ampliar los conceptos de
razón y de filosofía para que, liberadas del racionalismo, puedan volver a dar sentido a la
vida real. Una razón así ampliada con “experiencias de vida” y con un corazón palpitante
será mucho más capaz de acoger una fe que le es ofrecida no como un derecho, un silogismo
o una carga, sino como un don de amor. En consecuencia, la fe deja de percibirse
como algo irracional, ajeno y accesorio “como un gusto personal”, y se convierte en un
impulso auténticamente razonable y cordial que cambia la mirada del hombre sobre la
existencia y el cristianismo y transfigura su vida en santidad.
2015-01-05T12:29:17Z
2015-01-05T12:29:17Z
2014
article
2386-2912
http://hdl.handle.net/10641/1048
eng
Relectiones, Nº 01
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Universidad Francisco de Vitoria
oai:ddfv.ufv.es:10641/34882023-11-28T23:00:11Zcom_10641_1919col_10641_1921oai:ddfv.ufv.es:10641/25942022-01-27T10:48:01Zcom_10641_132col_10641_1434
The recognition of the sacred in theories of possible worlds: some hermeneutic orientations.
Abellán-García Barrio, Álvaro
Encinas, Arturo
Fiction
Possible worlds
Profane
Reality
Sacred
This article addresses the question of the possibilities for the recognition
of the sacred in theories of possible worlds, an area
which has not been explicitly developed but that has important
consequences based on each author’s underlying notion of
“world”. The study will focus on three representatives of the
logical-analytical current (Ryan, Albaladejo and Dole zel) and on
three other authors who take a phenomenological-existential
approach (Eco, Pavel and Garc ıa-Noblejas). Despite the systematic
clarity of the model of analysis applied by the former authors,
their fundamental understanding of reality may inhibit the identification
of the sacred as “real”. Although the existential current is
a priori more disposed to recognize the sacred, a more systematic
approach in their analysis is required for the identification and
thematization of the sacred. The present paper examines the theoretical
presuppositions of each approach in recognizing the
sacred within narrations, as an element in the salvation or perdition
of fictional characters, which is essential for a full understanding
of both the sapiential value of fiction and the meaning of
many works of fiction. To conclude, the paper offers a series of
observations to assist in the systematization of the study of the
sacred in possible fictional worlds.
post-print
1.693 KB
2021-11-11T10:16:51Z
2021-11-11T10:16:51Z
2021
article
2375-3242
http://hdl.handle.net/10641/2594
10.1080/23753234.2021.1961594
eng
https://www.tandfonline.com/doi/full/10.1080/23753234.2021.1961594?scroll=top&needAccess=true
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Church, Communication and Culture
oai:ddfv.ufv.es:10641/29292022-04-26T00:00:20Zcom_10641_132col_10641_1441
Verbal Fluency Tasks: Influence of Age, Gender, and Education and Normative Data for the Spanish Native Adult Population.
Lubrini, Genny
Periáñez, José A.
Laseca-Zaballa, Garazi
Bernabeu Brotons, Elena
Ríos Lago, Marcos
Assessment
Cross-cultural
Aging
Normative data
Verbal fluency
Objective: Phonological and semantic verbal fluency (VF) tasks are frequently used to assess language and executive functions in both clinical and research settings. F, A, and S are the most commonly used letters in phonological tasks across languages and cultures. Unfortunately, the lack of norms for the native Spanish population for these letters, and for certain semantic categories such as “proper names,” may lead to misinterpretation of scores due to demographic differences. The aim of the present study was to provide normative data for F, A, and S and for “proper names,” “animals,” and “fruits and vegetables” for the native Spanish population. Method: 257 healthy subjects took part in the study (ages: 17–100 years, 3–20 years of education). Correlation, multiple regression, and t-tests were used to select the most appropriate variables for stratification. Results: Education was the best predictor of performance in all tasks, followed by age. Given that t-test results showed no differences related to gender, with the only exception of the semantic category “animals,” this variable was not considered for stratification. Consequently, the data were stratified in two education levels (<13, ≥13 years of education) and in two age levels (<60, ≥60) within the low-educational level group. Mean, standard deviation, and percentile scores for each group are provided. Conclusions: The present norms provide a reference for clinicians assessing VF. This data may also facilitate comparisons with other normative studies in cross-cultural and cross-linguistic research.
pre-print
369 KB
2022-04-25T09:29:40Z
2022-04-25T09:29:40Z
2021
article
0887-6177
http://hdl.handle.net/10641/2929
10.1093/arclin/acab056
eng
https://academic.oup.com/acn/article-abstract/37/2/365/6330179?redirectedFrom=fulltext
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Archives of Clinical Neuropsychology
oai:ddfv.ufv.es:10641/7722019-07-23T16:22:38Zcom_10641_252col_10641_1444
Shakespeare como filosofía
Pérez Gállego, Cándido
Shakespeare, William (1564-1616)-Crítica e interpretación
Teatro inglés
post-print
862,13 KB
2013-04-18T01:58:52Z
2013-04-18T01:58:52Z
2003
article
1134-7627
http://hdl.handle.net/10641/772
spa
Mar Océana, Nº 14-15
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Asociación Francisco López de Gómara
Centro Universitario Francisco de Vitoria
oai:ddfv.ufv.es:10641/18282021-02-04T09:24:43Zcom_10641_132col_10641_1438
Under reporting of Parkinson’s disease on death certificates: a population-based study (NEDICES)
Benito León, Julián
Louis, Elan D.
Villarejo Galende, Alberto
Romero Muñoz, Juan Pablo
Bermejo-Pareja, Félix
Death certificates
Elderly
Epidemiology
Parkinson's disease
Population-based study
Under-reporting
Background
Parkinson's disease is frequently omitted as a cause of death from death certificates. A limitation of previous studies that attempted to assess the validity of death certificates is that population-dwelling cases, with milder, undiagnosed Parkinson's disease were likely excluded. As a result, those studies likely overestimated the validity of death certificates because they did not include these milder cases. We assessed the validity of death certificates in a prospective population-based study (NEDICES), which includes previously undiagnosed Parkinson's disease cases detected during the assessment.
Methods
3926 community-dwelling elderly subjects with and without Parkinson's disease were followed during a median of 12.6 years, after which the death certificates of those who died were examined. We calculated the proportion of cases of clinically diagnosed Parkinson's disease for whom a diagnosis of Parkinson's disease was certified as the basic cause of death on death certificates.
Results
1791 (45.6%) of the 3926 participants died over a median follow-up of 7.1 years, including 82 (73.9%) deaths among 111 participants with Parkinson's disease. Parkinson's disease was rarely certified as the basic cause of death (14.6%). Gender, disease stage and the period during which the study was conducted (i.e., 1994 to 2007) did not influence the likelihood that Parkinson's disease would be reported.
Conclusions
Our findings reinforce the notion that the reporting of Parkinson's disease on death certificates remains poor. This suggests a lack of awareness of the importance of Parkinson's disease as a cause of death.
pre-print
261 KB
2020-01-20T12:53:11Z
2020-01-20T12:53:11Z
2014
article
0022-510X
http://hdl.handle.net/10641/1828
10.1016/j.jns.2014.08.048
eng
https://www.sciencedirect.com/science/article/abs/pii/S0022510X14006443?via%3Dihub
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
The Journal of Neuroscience
oai:ddfv.ufv.es:10641/41492024-02-28T01:00:10Zcom_10641_132col_10641_1424
Modelling performance by continents in swimming.
Yustres Amores, Inmaculada
Santos del Cerro, Jesús
González-Mohíno, Fernando
Hermosilla, F.
González-Ravé, José María
Modelling
Performance
Swimming
Introduction: There is a growing interest in the scientific community about the progression and congruity in the performance of talented participants who complete representing different nations in the most important international events. The prediction of incoming performances is nowadays in demand with the objective of returning in talent investment. Talent identification programs have tried to select and develop sports talent over years. However, to our knowledge, there is a lack of research about success in swimming World Championships (WCs) performance considering continents-country and how successful outcomes are influenced by these variables. Therefore, the primary goal is to analyze the effect of early specialization comparing the performance progression model of the countries gathered by continents.
Methods: Participant’s data from all Junior and Senior WCs between 2006 and 2017 from International Swimming Federation (FINA). One-way ANOVA, ANCOVA and regression model were used to explain whether the variable category, age, best z-score, experience, and continent influences the performance obtained in Absolute WC.
Results: Significant differences (p < 0.01) were found between the average performance obtained by the two different categories (junior: swimmers participating in junior WCs before senior WCs; senior: swimmers participating in senior WCs without previous participation in junior WCs), where swimmers from category junior showed significant better performance’s times than seniors, except in America. ANCOVA results showed that generally, the greatest differences where in the earliest ages, with best performance registered in category junior in all the continents. Also, the experience was a significant variable in the general model.
Conclusion: Swimmers who had participated in junior category prior absolute obtained better performance’s times than those swimmers who participated directly in absolute, in the first participation in senior WC. Thus, early specialization is a key factor to obtain better results in senior WCs for all the continents, except in America.
post-print
1150 KB
2024-02-27T13:03:57Z
2024-02-27T13:03:57Z
2023
article
1664-042X
https://hdl.handle.net/10641/4149
10.3389/fphys.2023.1075167
eng
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1075167/full
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Frontiers in Physiology
oai:ddfv.ufv.es:10641/38412024-02-01T01:00:08Zcom_10641_132col_10641_1801
A multivariate causality analysis of CO2 emission, electricity consumption, and economic growth: Evidence from Western and Central Africa.
Gyamerah, Samuel Asante
Gil Alana, Luis A.
CO2 emissions
Africa
Electricity consumption
Economic growth
Vector error correction model
The vector error correction model is used to examine the short- and long-run impacts of electricity
consumption and economic growth on CO2 emissions in Western and Central Africa from 1970 to
2020. This paper adopted time series vector error correction model (VECM) approach to conduct
stationarity test, cointegration test, stability test, and Granger causality test. Cointegration tests
are used to examine the long-run impact of electricity consumption and economic growth on CO2
emissions. It was revealed that CO2 emission, electricity consumption and economic growth are
co-integrated. Electricity consumption and economic growth have a significant and positive effect
on CO2 emission. The study also revealed that the adjustment process is not driven by electricity
consumption, and anytime there is a deviation from the long-run equilibrium, economic growth
and CO2 emission adjust to restore the long-run equilibrium. From the short-run Granger causality, electricity consumption and economic growth do not Granger cause CO2 emissions.
However, past values of CO2 emissions have an effect on the present value of economic growth.
Generally, long-run dynamics of electricity consumption and economic growth were established
to have a greater impact on CO2 emission than the short-run dynamics. Hence, it is important to
promote green economic concepts in the area.
post-print
965 KB
2024-01-31T10:17:48Z
2024-01-31T10:17:48Z
2023
article
2405-8440
https://hdl.handle.net/10641/3841
10.1016/j.heliyon.2023.e12858
eng
https://www.sciencedirect.com/science/article/pii/S2405844023000658
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Heliyon
oai:ddfv.ufv.es:10641/16702019-09-06T00:01:06Zcom_10641_132col_10641_1423
Combination of bioanalytical approaches and quantitative proteomics for the elucidation of the toxicity mechanisms associated to TiO2 nanoparticles exposure in human keratinocytes.
Montalvo Quiros, Sandra
Luque García, José L.
TiO2 nanoparticles
Toxicity mechanisms
Quantitative proteomics
Titanium dioxide nanoparticles (TiO2-NPs) are being used in several consumer products. The high refractive
index of nano-scaled titanium dioxide particles allows them to protect from UV radiation, and so, they can be
found as one of the main components of cosmetics and suncreens. Many studies have reported the potential
toxicological effects associated to TiO2-NPs such as ROS generation, DNA damage, apoptosis and cell cycle
arrest, among others. The continuous and systematic use of TiO2-NPs in cosmetic products requires a full
comprehension of the risks involving their sustained contact with the human skin. Thus, it is important to
evaluate not only the hazardous effects but to elucidate the biomolecular mechanisms involved in such effects.
Based on this premises, we have evaluated the potential toxicity of TiO2-NPs using a human epithelial cell
culture (HaCaT cells) as in-vitro model, together with different bioanalytical approaches and mass spectrometrybased quantitative proteomics, to gain a deeper insight into the molecular mechanisms of toxicity associated to
TiO2-NPs exposure
pre-print
451 KB
2019-09-05T11:36:51Z
2019-09-05T11:36:51Z
2019
article
0278-6915
http://hdl.handle.net/10641/1670
10.1016/j.fct.2019.03.036
eng
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Food and Chemical Toxicology
oai:ddfv.ufv.es:10641/26982022-01-20T01:00:22Zcom_10641_132col_10641_1434
Sobre hominización y humanización.
Sánchez Palencia, Ángel
post-print
312 KB
2022-01-19T14:04:14Z
2022-01-19T14:04:14Z
2020
article
2254-9668
http://hdl.handle.net/10641/2698
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Naturaleza y libertad
oai:ddfv.ufv.es:10641/39152024-02-12T15:27:20Zcom_10641_132col_10641_1424
The effect of pitch size manipulation during small sided-games performed by different age category football players: a pilot study.
Espada, Mário C.
Gamonales, José M.
Verardi, Carlos E.L.
Pessôa Filho, Dalton M.
Ferreira, Cátia C.
Robalo, Ricardo A.M.
Dias, Amândio A.P.
Hernández-Beltrán, Víctor
Santos, Fernando J.
Reduced games
Global positioning system
Training
Internal load
External load
This research aimed to analyse the pitch size manipulation effect on internal and
external load and to study the age effect on the studied variables in different smallsided
games (SSGs) formats. Male U-12 (n = 8), U-15 (n = 8) youth football players,
and U-23 (n = 8) professional cohorts participated in the study. Two SSGs formats
were analyzed, goalkeeper (GK) + 4 vs. 4 + GK, 3 minutes play in 20×30 m and 24
× 36 m, with 3 minutes rest between bouts. The variance analysis Anova two-way
was used to analyse two independent factors, pitch size, and age group. The playing
area manipulation had an effect under the following variables: distance (p<0.001),
speed 0–6 km/h (p < 0.001), speed 12–18 km/h (p < 0.001), speed 18–21 km/h (p
< 0.001), accelerations (Ac.) 1–2 m/s2 (p < 0.001), decelerations (Dc.) 2–3 m/s2
(p < 0.001), metabolic power (Pmet) (p < 0.001) and high metabolic load distance
(HMLD) (p < 0.001). The age group influenced the distance covered (p < 0.001),
speed 0–6 km/h (p < 0.001), speed 6–12 km/h (p < 0.001), speed 12–18 km/h (p
< 0.001), speed 21–24 km/h (p = 0.030), Ac. 1–2 m/s2 (p < 0.001), Ac. 1–2 m/s2
(p < 0.001Pmet (p < 0.001), HMLD (p < 0.001) and training impulse (TRIMP)
(p < 0.001). Playing area manipulation in football SSGs promotes an increase in
external load intensity, namely, larger areas are suitable for larger effects at high
speeds (>21 km/h) and TRIMP. A careful and detailed evaluation of training tasks,
considering the different age category football players, is important to optimize the
planning in football, aiming at improving players’ condition and performance and
avoiding health problems and injuries
post-print
762 KB
2024-02-08T11:05:43Z
2024-02-08T11:05:43Z
2023
article
1875-6867
https://hdl.handle.net/10641/3915
10.22514/jomh.2023.110
eng
https://www.jomh.org/articles/10.22514/jomh.2023.110
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Journal of Men's Health
oai:ddfv.ufv.es:10641/24682024-01-29T11:12:53Zcom_10641_9col_10641_1415
Tratamiento deontológico de la muerte en América Latina a través del fotoperiodismo durante la pandemia del COVID-19.
Rodríguez Sánchez, Beatriz
Musicco Nombela, Daniela
pre-print
26592 KB
2021-10-04T09:58:53Z
2021-10-04T09:58:53Z
2021
bachelorThesis
http://hdl.handle.net/10641/2468
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
oai:ddfv.ufv.es:10641/11762019-07-23T15:58:23Zcom_10641_132col_10641_1438
Impact of the Timing of Metoprolol Administration During STEMI on Infarct Size and Ventricular Function.
Mateos Rodríguez, Alonso
Metoprolol
STEMI
Ventricular Function
Infarct
Infarto
BACKGROUND Pre-reperfusion administration of intravenous (IV) metoprolol reduces infarct size in ST-segment
elevation myocardial infarction (STEMI).
OBJECTIVES This study sought to determine how this cardioprotective effect is influenced by the timing of metoprolol
therapy having either a long or short metoprolol bolus-to-reperfusion interval.
METHODS We performed a post hoc analysis of the METOCARD-CNIC (effect of METOprolol of CARDioproteCtioN
during an acute myocardial InfarCtion) trial, which randomized anterior STEMI patients to IV metoprolol or control before
mechanical reperfusion. Treated patients were divided into short- and long-interval groups, split by the median time from
15 mg metoprolol bolus to reperfusion. We also performed a controlled validation study in 51 pigs subjected to 45 min
ischemia/reperfusion. Pigs were allocated to IV metoprolol with a long ( 25 min) or short ( 5 min) pre-perfusion
interval, IV metoprolol post-reperfusion (þ60 min), or IV vehicle. Cardiac magnetic resonance (CMR) was performed
in the acute and chronic phases in both clinical and experimental settings.
RESULTS For 218 patients (105 receiving IV metoprolol), the median time from 15 mg metoprolol bolus to reperfusion
was 53 min. Compared with patients in the short-interval group, those with longer metoprolol exposure had smaller
infarcts (22.9 g vs. 28.1 g; p ¼ 0.06) and higher left ventricular ejection fraction (LVEF) (48.3% vs. 43.9%; p ¼ 0.019) on
day 5 CMR. These differences occurred despite total ischemic time being significantly longer in the long-interval group
(214 min vs. 160 min; p < 0.001). There was no between-group difference in the time from symptom onset to metoprolol
bolus. In the animal study, the long-interval group (IV metoprolol 25 min before reperfusion) had the smallest infarcts
(day 7 CMR) and highest long-term LVEF (day 45 CMR).
CONCLUSIONS In anterior STEMI patients undergoing primary angioplasty, the sooner IV metoprolol is administered
in the course of infarction, the smaller the infarct and the higher the LVEF. These hypothesis-generating
clinical data are supported by a dedicated experimental large animal study.
post-print
808 KB
2016-06-06T10:11:40Z
2016-06-06T10:11:40Z
2016
article
0735-1097
http://hdl.handle.net/10641/1176
eng
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Journal of the American College of Cardiology, Vol. 67, Nº 18
oai:ddfv.ufv.es:10641/29972022-07-10T22:00:11Zcom_10641_1919col_10641_1921oai:ddfv.ufv.es:10641/31232022-09-24T00:00:09Zcom_10641_9col_10641_3122
Smart cities competing for talent: neural nets and clustering algorithm for cities.
Meneses Muñoz, Marta
Smart Cities
Attractiveness
Technology
Clustering
Autoencoder
The future of cities is based on the 3Ts: technology, talent and tolerance. Talent is a fundamental pillar for the development of cities and therefore we must know how to be an attractive city to attract it. Choosing the place where we can develop our potential and put it at the service of others is what every talented young person wants to do. In a globalized world, the information that we can evaluate to facilitate decision making is increasing. As a result, there is great competition and, just like companies, cities need to attract that talent that will lead them to advance and grow.
Through this study, we will group 175 cities considered Smart Cities, by similarity through an unsupervised model without any human bias or subjective opinion. In the same way, this study will help governors to know in which group of cities they are in the search for talent and to know what they should offer to improve their positioning. Thus, we will be able to foster the desire to make cities the place where the person is the center and attract technology companies that enrich cities, and therefore we will also be considering the first "T", technology.
pre-print
1825 KB
2022-09-23T11:21:51Z
2022-09-23T11:21:51Z
2022
bachelorThesis
https://hdl.handle.net/10641/3123
eng
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
oai:ddfv.ufv.es:10641/36202024-01-03T01:00:09Zcom_10641_132col_10641_1423
Biochemical and mutational studies of allantoinase from Bacillus licheniformis CECT 20T.
Martínez-Gómez, Ana Isabel
Soriano Maldonado, Pablo
Martínez-Rodríguez, Sergio
Allantoinases (allantoin amidohydrolase, E.C. 3.5.2.5) catalyze the hydrolysis of the amide bond of allantoin to form allantoic acid, in those organisms where allantoin is not the final product of uric acid degradation. Despite their importance in the purine catabolic pathway, sequences of microbial allantoinases with proven activity are scarce, and only the enzyme from Escherichia coli (AllEco) has been studied in detail in the genomic era. In this work, we report the cloning, purification and characterization of the recombinant allantoinase from Bacillus licheniformis CECT 20T (AllBali). The enzyme was a homotetramer with an apparent Tm of 62 ± 1 °C. Optimal parameters for the enzyme activity were pH 7.5 and 50 °C, showing apparent Km and kcat values of 17.7 ± 2.7 mM and 24.4 ± 1.5 s−1, respectively. Co2+ proved to be the most effective cofactor, inverting the enantioselectivity of AllBali when compared to that previously reported for other allantoinases. The common ability of different cyclic amidohydrolases to hydrolyze distinct substrates to the natural one also proved true for AllBali. The enzyme was able to hydrolyze hydantoin, dihydrouracil and 5-ethyl-hydantoin, although at relative rates 3–4 orders of magnitude lower than with allantoin. Mutagenesis experiments suggest that S292 is likely implicated in the binding of the allantoin ring through the carbonyl group of the polypeptide main chain, which is the common mechanism observed in other members of the amidohydrolase family. In addition, our results suggest an allosteric effect of H2O2 toward allantoinase.
pre-print
829 KB
2024-01-02T07:58:02Z
2024-01-02T07:58:02Z
2014
article
0300-9084
https://hdl.handle.net/10641/3620
10.1016/j.biochi.2013.12.002
eng
https://www.sciencedirect.com/science/article/abs/pii/S0300908413004392
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Biochimie
oai:ddfv.ufv.es:10641/20372021-03-17T08:23:45Zcom_10641_132col_10641_1420
Air quality in London: evidence of persistence, seasonality and trends.
Gil Alana, Luis A.
Yaya, OlaOluwa S.
Carmona González, Nieves
London
Air quality
Time trends
Long memory
Fractional integration
Seasonality
The poor air quality in the London metropolis has sparked our interest in studying the time series dynamics of air pollutants in the city. The dataset consists of roadside and background air quality for seven standard pollutants: nitric oxide (NO), nitrogen dioxide (NO2), oxides of nitrogen (NOx), ozone (O3), particulate matter (PM10 and PM2.5) and sulphur dioxide (SO2), using fractional integration to investigate issues such as persistence, seasonality and time trends in the data. Though we notice a large degree of heterogeneity across pollutants and a persistent behaviour based on a long memory pattern is observed practically in all cases. Seasonality and decreasing linear trends are also found in some cases. The findings in the paper may serve as a guide to air pollution management and European Union (EU) policymakers.
pre-print
455 KB
2020-10-27T11:13:06Z
2020-10-27T11:13:06Z
2020
article
0177-798X
http://hdl.handle.net/10641/2037
10.1007/s00704-020-03305-1
eng
https://link.springer.com/article/10.1007/s00704-020-03305-1
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Theoretical and Applied Climatology
oai:ddfv.ufv.es:10641/38652024-02-06T01:00:09Zcom_10641_132col_10641_1428
Analysing the sentiments about the education system trough Twitter
Mouronte López, Mary Luz
Savall Ceres, Juana
Columbrans, Aina Mora
Education system
Twitter
Sentiment analysis
Data science
Social networks
Perception of education
This paper applies Information and Communication Technologies (ICT) as well as
data analysis to gain a better understanding of the existing perception on the education
system. 45,278 tweets were downloaded and processed. Using a lexicon-based
approach, examining the most frequently used words, and estimating similarities
between terms, we detected that a predominantly negative perception of the education
system exists in most of the analysed countries. A positive perception is identified in
certain low-income nations. Men exhibit a more positive sentiment than women as
well as a higher subjectivity in some countries. The countries that exhibit the most
positive perceptions India, Canada, Pakistan, Australia, South Africa and Kenya are
also those that manifest the highest subjectivity.
post-print
2,02 MB
2024-02-05T11:38:00Z
2024-02-05T11:38:00Z
2023
article
1573-7608
https://hdl.handle.net/10641/3865
10.1007/s10639-022-11493-8
eng
https://link.springer.com/article/10.1007/s10639-022-11493-8
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Education and Information Technologies
oai:ddfv.ufv.es:10641/37812024-02-28T12:21:22Zcom_10641_132col_10641_1422
La aplicación del análisis descriptivo en dibujo y anatomía morfológica y del movimiento.
Ramos Fabra, Lidón
pre-print
180 KB
2024-01-22T12:17:41Z
2024-01-22T12:17:41Z
2023
bookPart
Comunicación, creación artística y audiovisual: un marco para la innovación educativa.
978-84-1170-148-8
https://hdl.handle.net/10641/3781
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
closedAccess
Dykinson
oai:ddfv.ufv.es:10641/35912023-12-16T01:00:10Zcom_10641_132col_10641_1423
Physical Exercise following bariatric surgery in women with Morbid obesity Study protocol clinical trial (SPIRIT compliant).
Soriano Maldonado, Alberto
Martínez-Forte, Sonia
Ferrer-Márquez, Manuel
Martínez-Rosales, Elena
Hernández-Martínez, Alba
Carretero-Ruiz, Alejandro
Villa-González, Emilio
Barranco-Ruiz, Yaira
Rodríguez-Pérez, Manuel A.
Torrente-Sánchez, María José
Carmona-Rodríguez, Lorena
Soriano Maldonado, Pablo
Vargas-Hitos, José A.
Casimiro-And ujar, Antonio J.
Artero, Enrique G.
Fernández-Alonso, Ana M.
Background: Severe and morbid obesity are increasing globally, particularly in women. As BMI increases, the likelihood of
anovulation is higher. The primary aim of the EMOVAR clinical trial is to examine, over the short (16 weeks) and medium (12 months)
term, the effects of a supervised physical exercise program (focused primarily on aerobic and resistance training) on ovarian function
in women with severe/morbid obesity who have undergone bariatric surgery. Secondary objectives are to examine the effects of the
intervention on chronic inflammation, insulin resistance, arterial stiffness, physical fitness, and health-related quality of life.
Methods: This is a randomized controlled trial in which ∼40 female bariatric surgery patients, aged between 18 and 45 years old, will
be included. Participants assigned to the experimental group will perform a total of 48 sessions of supervised concurrent (strength and
aerobic) training (3sessions/week, 60min/session) spread over 16 weeks. Patients assigned to the control group will receive lifestyle
recommendations. Outcomes will be assessed at baseline, week 16 (i.e., after the exercise intervention) and 12 months after surgery.
The primary outcome is ovarian function using the Sex-Hormone Binding Globuline, measured in serum. Secondary outcomes are
serum levels of anti-mullerian hormone, TSH, T4, FSH, LH, estradiol, prolactine, and free androgen index, as well as oocyte count, the
diameters of both ovaries, endometrial thickness, and uterine arterial pulsatility index (obtained from a transvaginal ultrasound), the
duration of menstrual bleeding and menstrual cycle duration (obtained by personal interview) and hirsutism (Ferriman Gallwey Scale).
Other secondary outcomes include serummarkers of chronic inflammation and insulin resistance (i.e., C-reactive protein, interleukin 6,
tumor necrosis factor-alpha, leptin, glomerular sedimentation rate, glucose, insulin and theHOMA-IR), arterial stiffness, systolic, diastolic
and mean blood pressure, body composition, and total weight loss. Physical fitness (including cardiorespiratory fitness, muscular
strength, and flexibility), health-related quality of life (SF-36 v2) and sexual function (Female Sexual Function Index) will also be measured.
Discussion: This study will provide, for the first time, relevant information on the effects of exercise training on ovarian function and
underlying mechanisms in severe/morbid obese women following bariatric surgery.
post-print
502 KB
2023-12-15T12:31:01Z
2023-12-15T12:31:01Z
2020
article
1536-5964
https://hdl.handle.net/10641/3591
10.1097/MD.0000000000019427
eng
https://journals.lww.com/md-journal/fulltext/2020/03200/physical_exercise_following_bariatric_surgery_in.15.aspx
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Medicine
oai:ddfv.ufv.es:10641/35592023-12-13T01:00:07Zcom_10641_132col_10641_1423
Defective Ribonucleoside Diphosphate Reductase Impairs Replication Fork Progression in Escherichia coli.
Guarino Almeida, Estrella
Jiménez Sánchez, Alfonso
Guzmán, Elena C.
The observed lengthening of the C period in the presence of a defective ribonucleoside diphosphate reductase has been assumed to be due solely to the low deoxyribonucleotide supply in the nrdA101 mutant strain. We show here that the nrdA101 mutation induces DNA double-strand breaks at the permissive temperature in a recB-deficient background, suggesting an increase in the number of stalled replication forks that could account for the slowing of replication fork progression observed in the nrdA101 strain in a Rec+ context. These DNA double-strand breaks require the presence of the Holliday junction resolvase RuvABC, indicating that they have been generated from stalled replication forks that were processed by the specific reaction named “replication fork reversal.” Viability results supported the occurrence of this process, as specific lethality was observed in the nrdA101 recB double mutant and was suppressed by the additional inactivation of ruvABC. None of these effects seem to be due to the limitation of the deoxyribonucleotide supply in the nrdA101 strain even at the permissive temperature, as we found the same level of DNA double-strand breaks in the nrdA+ strain growing under limited (2-μg/ml) or under optimal (5-μg/ml) thymidine concentrations. We propose that the presence of an altered NDP reductase, as a component of the replication machinery, impairs the progression of the replication fork, contributing to the lengthening of the C period in the nrdA101 mutant at the permissive temperature.
post-print
206 KB
2023-12-12T12:40:00Z
2023-12-12T12:40:00Z
2007
article
0021-9193
https://hdl.handle.net/10641/3559
10.1128/jb.01632-06
eng
https://journals.asm.org/doi/10.1128/jb.01632-06
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Journal of Bacteriology
oai:ddfv.ufv.es:10641/31832022-12-10T01:00:11Zcom_10641_132col_10641_1423
Conventional Cervical Exercises Compared with a Mixed-Reality-Based Game in Asymptomatic Subjects: An Exploratory Crossover Pilot Study.
Diaz-Saez, Marta C.
Navarro-Fernández, Gonzalo
Fernandez-Carnero, Josué
Garrigós-Pedrón, Miriam
Romero Muñoz, Juan Pablo
Beltran-Alacreu, Hector
Virtual reality
Mixed reality
Cervical spine
HoloLens
Mixed reality presents itself as a potential technological tool for the management of people
with musculoskeletal disorders, without having as many adverse side effects as immersive virtual
reality. The objective of this study was to explore the possibilities of a mixed-reality game, performing
task-oriented cervical exercises compared to conventional therapeutic exercises in sensorimotor
outcome measures in asymptomatic subjects. A randomized crossover pilot study was performed
with two intervention groups: a mixed-reality group (MRG) and a conventional exercise group (CEG).
The cervical joint position error test (CJPET) and deep cervical flexor endurance test (DCFET) were
measured as sensorimotor outcomes. Statistically significant differences were found in the pre–post
comparison in the DCFET for both groups (MRG: t = �����3.87, p < 0.01; CEG: t = �����4.01, p < 0.01)
and in the extension of the CJPET for the MRG (t = 3.50, p < 0.01). The rest of the measurements
showed no significant differences comparing both groups pre- and postintervention (p > 0.05). Mixed
reality has apparently the same positive effects as conventional exercises in sensorimotor outcomes
in asymptomatic subjects. These results could help in future studies with mixed virtual reality in the
management of people with musculoskeletal disorders.
post-print
882 KB
2022-12-09T12:40:35Z
2022-12-09T12:40:35Z
2022
article
2076-3417
https://hdl.handle.net/10641/3183
10.3390/app12073657
eng
https://www.mdpi.com/2076-3417/12/7/3657
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Applied Sciences
oai:ddfv.ufv.es:10641/18322021-02-04T09:24:43Zcom_10641_132col_10641_1438
The NEDICES Study: Recent Advances in the Understanding of the Epidemiology of Essential Tremor.
Romero Muñoz, Juan Pablo
Benito Léon, Julián
Bermejo Pareja, Félix
Epidemiology
Essential tremor
BACKGROUND:
Essential tremor (ET) is the most common tremor disorder. ET has classically been viewed as a benign monosymptomatic condition. Yet over the past 10 years, a growing body of evidence indicates that this is a progressive condition that is clinically heterogeneous, and may be associated with a variety of different features. Large epidemiological studies such as the Neurological Disorders of Central Spain (NEDICES), a longitudinal, population-based survey, have contributed significantly to the changing view of the disease. Our aim is to review some of the main results of NEDICES within the larger framework of the epidemiology of ET.
METHODS:
Data for this review were gathered from all our articles published up to October 2011 regarding NEDICES study and "Essential Tremor".
RESULTS:
We have published 18 articles up to October 2011. The prevalence, incidence, and mortality of ET were analyzed in this cohort. In addition, ET was found to be associated with increased frailty and low morale, as well as with a series of non-motor manifestations, including cognitive deficits, mild cognitive impairment, dementia, depressive symptoms, and hearing impairment. Finally, the link between ET and Parkinson's disease (PD) was formally quantified in the NEDICES study, which demonstrated that the risk of developing incident PD was 4.3 times higher in prevalent ET cases than in age-matched controls without ET.
CONCLUSIONS:
This review highlights the contributions of NEDICES towards the advancement of current knowledge of the epidemiology and clinical features of ET, and emphasizes the importance of population-based studies towards the understanding of complex, ageing-related diseases.
post-print
1010 KB
2020-01-21T11:23:23Z
2020-01-21T11:23:23Z
2012
article
2160-8288
http://hdl.handle.net/10641/1832
10.7916/D8N58K4H
eng
https://tremorjournal.org/index.php/tremor/article/view/70
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Tremor and Other Hyperkinet Movements
oai:ddfv.ufv.es:10641/40152024-02-16T01:00:11Zcom_10641_132col_10641_1424
Evolution of Documents Related to Biomechanics Research in Gymnastics.
Hernández-Beltrán, Víctor
Espada, Mário C.
Muñoz-Jiménez, Jesús
León, Kiko
Ferreira, Cátia C.
Parraca, Jose A
Gamonales, José M
Bibliometric
Acrobatics
Biomechanical analysis has been one of the most used procedures when aiming to improve performance in sports and is also very relevant and decisive in the final classification of competitive events in sports such as gymnastics. Hence, this study sought to provide an overview of the number of scientific literature publications related to biomechanics research in gymnastics. The document search was completed in March 2023 and reflected a bibliometric analysis considering the published manuscripts up to 31 December 2022. Data collection was performed on the Web of Science, following the bibliometric analysis law, using Microsoft Excel and VosViewer Software (v1.6.19) for analysis and data processing. A total of 325 documents related to the topic under study were located. The results highlight that the older manuscripts date from 1980, with a growing trend of publications from that moment until now and a very visible increase in 2015, and that Sport Science is the category associated with more published manuscripts. A total of 30 manuscripts have 30 or more citations, 746 authors and co-authors are associated with the publications, and 58 co-authorships have published one or more studies. Moreover, 47 countries or regions have been associated with the topic under study, with the USA, England, and Australia being the countries with the most published articles and citations. The study also found that the highest frequency keywords are: “gymnastics” (n = 122), “biomechanics” (n = 73), “simulation” (n = 27), and “performance” (n = 25), considering the average year of publication of the documents, “balance” (n = 11), “artistic gymnastic” (n = 14) and “training” (n = 25) are the most frequently used terms. This study reveals that the topic of biomechanics in gymnastics has shown sustained growth and deserves the attention of the scientific community, but at the same time, there is still much room for research development.
post-print
3329 KB
2024-02-15T12:09:44Z
2024-02-15T12:09:44Z
2023
article
2673-7078
https://hdl.handle.net/10641/4015
10.3390/biomechanics3040039
eng
https://www.mdpi.com/2673-7078/3/4/39
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Biomechanics
oai:ddfv.ufv.es:10641/6282019-07-23T16:22:13Zcom_10641_252col_10641_1444
Cultura y libertad
Gros Espiell, Héctor
Cultura-Filosofía
Libertad-Filosofía
post-print
1,31 MB
2013-03-08T04:27:58Z
2013-03-08T04:27:58Z
1995
article
1134-7627
http://hdl.handle.net/10641/628
spa
Mar Océana, Nº 02
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Asociación Francisco López de Gómara
oai:ddfv.ufv.es:10641/40272024-02-16T01:00:12Zcom_10641_132col_10641_1438
New environmental factors related to diabetes risk in humans: Emerging bisphenols used in synthesis of plastics.
Moreno-Gómez-Toledano, Rafael
Delgado-Marín, María
Cook-Calvete, Alberto
González-Cucharero, Claudia
Alcharani, Nunzio
Jiménez-Guirado, Beatriz
Hernandez, Ignacio
Ramírez Carracedo, Rafael
Tesoro Santos, Laura
Botana, Laura
Sánchez-Esteban, Sandra
Diez-Mata, Javier
Zamorano, Jose Luis
Bosch, Ricardo J.
Zaragoza Sánchez, Carlos
Saura Redondo, Marta
Bisphenol S
Bisphenol F
Bisphenol AF
Diabetes mellitus
BACKGROUND
Diabetes mellitus (DM) is one of the largest global health emergencies of the 21st century. In recent years, its connection with environmental pollutants, such as bisphenol A (BPA), has been demonstrated; consequently, new structurally similar molecules are used to replace BPA in the plastics industry (BPS, BPF and BPAF).
AIM
To carry out a systematic review to allow coherent evaluation of the state of the art. Subsequently, a meta-analysis was performed to unify the existing quantitative data.
METHODS
Firstly, a systematic review was carried out, using the terms “(bisphenol) AND (Diabetes OR Hyperglycemia)”, to maximize the number of results. Subsequently, three authors analyzed the set of articles. Finally, a meta-analysis was performed for each BP, using RevMan software. In addition, funnel plots were developed to study publication bias.
RESULTS
The systematic analysis of the literature revealed 13 recent articles (2017–2023) related to the study paradigm. The qualitative analysis showed interesting data linking diabetes to the three most widely used substitute BPs in the industry: BPS, BPF and BPAF. Finally, the meta-analysis determined a positive relationship with BPS, BPF and BPAF, which was only statistically significant with BPS.
CONCLUSION
There is a need to apply the precautionary principle, regulating the use of new BPs. Therefore, replacing BPA with BPS, BPF or BPAF is unlikely to protect the population from potential health risks, such as DM
post-print
2334 KB
2024-02-15T20:54:25Z
2024-02-15T20:54:25Z
2023
article
1948-9358
https://hdl.handle.net/10641/4027
10.4239/wjd.v14.i8.1301
eng
https://www.wjgnet.com/1948-9358/full/v14/i8/1301.htm
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
World Journal of Diabetes
oai:ddfv.ufv.es:10641/23492021-07-22T00:00:21Zcom_10641_132col_10641_1424
Caffeine increases whole-body fat oxidation during 1 h of cycling at Fatmax.
Ruiz Moreno, Carlos
Gutiérrez Hellín, Jorge
Amaro Gahete, Francisco J.
González García, Jaime
Giráldez Costas, Verónica
Pérez García, Víctor
Del Coso, Juan
Endurance exercise
Substrate oxidation
Adverse effects
Purpose The ergogenic effect of caffeine on exercise of maximum intensity has been well established. However, there is controversy regarding the effect of caffeine on shifting substrate oxidation at submaximal exercise. The aim of this study was to investigate the effect of acute caffeine ingestion on whole-body substrate oxidation during 1 h of cycling at the intensity that elicits maximal fat oxidation (Fatmax).
Methods In a double-blind, randomized, and counterbalanced experiment, 12 healthy participants (VO2max = 50.7 ± 12.1 mL/ kg/min) performed two acute experimental trials after ingesting either caffeine (3 mg/kg) or a placebo (cellulose). The trials consisted of 1 h of continuous cycling at Fatmax. Energy expenditure, fat oxidation rate, and carbohydrate oxidation rate were continuously measured by indirect calorimetry.
Results In comparison to the placebo, caffeine increased the amount of fat oxidized during the trial (19.4 ± 7.7 vs 24.7 ± 9.6 g, respectively; P = 0.04) and decreased the amount of carbohydrate oxidized (94.6 ± 30.9 vs 73.8 ± 32.4 g; P = 0.01) and the mean self-perception of fatigue (Borg scale= 11 ± 2 vs 10 ± 2 arbitrary units; P = 0.05). In contrast, caffeine did not modify total energy expenditure (placebo = 543 ± 175; caffeine = 559 ± 170 kcal; P = 0.60) or mean heart rate (125 ± 13 and 127 ± 9 beats/min; P = 0.30) during exercise. Before exercise, caffeine increased systolic and diastolic blood pressure whilst it increased the feelings of nervousness and vigour after exercise (P < 0.05).
Conclusion These results suggest that a moderate dose of caffeine (3 mg/kg) increases the amount of fat oxidized during 1 h of cycling at Fatmax. Thus, caffeine might be used as an effective strategy to enhance body fat utilization during submaxi- mal exercise. The occurrence of several side effects should be taken into account when using caffeine to reduce body fat in populations with hypertension or high sensitivity to caffeine.
pre-print
332 KB
2021-07-21T11:47:15Z
2021-07-21T11:47:15Z
2020
article
1436-6207
http://hdl.handle.net/10641/2349
10.1007/s00394-020-02393-z
eng
https://link.springer.com/article/10.1007/s00394-020-02393-z
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
European Journal of Nutrition
oai:ddfv.ufv.es:10641/24622021-10-05T00:00:31Zcom_10641_9col_10641_1415
La estrategia política del partido republicano para volver a hacerse con la mayoría electoral en Estados Unidos.
Fernández Quintana, Hugo
Pedreira Souto, Elena
pre-print
3140 KB
2021-10-04T09:35:11Z
2021-10-04T09:35:11Z
2021
bachelorThesis
http://hdl.handle.net/10641/2462
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
oai:ddfv.ufv.es:10641/35532023-12-12T01:00:09Zcom_10641_132col_10641_1423
Mechanisms and Regulation of Extracellular DNA Release and Its Biological Roles in Microbial Communities.
Ibáñez de Aldecoa, Alejandra L.
Zafra Amorós, Olga
González-Pastor, José E.
Extracellular DNA
Quorum sensing
Horizontal gene transfer
Microbial communities
Biofilms
Social behavior
The capacity to release genetic material into the extracellular medium has been reported
in cultures of numerous species of bacteria, archaea, and fungi, and also in the context
of multicellular microbial communities such as biofilms. Moreover, extracellular DNA
(eDNA) of microbial origin is widespread in natural aquatic and terrestrial environments.
Different specific mechanisms are involved in eDNA release, such as autolysis and active
secretion, as well as through its association with membrane vesicles. It is noteworthy
that in microorganisms, in which DNA release has been studied in detail, the production
of eDNA is coordinated by the population when it reaches a certain cell density, and is
induced in a subpopulation in response to the accumulation of quorum sensing signals.
Interestingly, in several bacteria there is also a relationship between eDNA release and the
development of natural competence (the ability to take up DNA from the environment),
which is also controlled by quorum sensing. Then, what is the biological function of
eDNA? A common biological role has not been proposed, since different functions have
been reported depending on the microorganism. However, it seems to be important
in biofilm formation, can be used as a nutrient source, and could be involved in DNA
damage repair and gene transfer. This review covers several aspects of eDNA research: (i)
its occurrence and distribution in natural environments, (ii) themechanisms and regulation
of its release in cultured microorganisms, and (iii) its biological roles. In addition, we
propose that eDNA release could be considered a social behavior, based on its quorum
sensing-dependent regulation and on the described functions of eDNA in the context of
microbial communities.
post-print
1697 KB
2023-12-11T09:20:27Z
2023-12-11T09:20:27Z
2017
article
1664-302X
https://hdl.handle.net/10641/3553
10.3389/fmicb.2017.01390
eng
https://www.frontiersin.org/articles/10.3389/fmicb.2017.01390/full
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Frontiers in Microbiology
oai:ddfv.ufv.es:10641/29812022-05-24T00:00:21Zcom_10641_132col_10641_1431
Radiofrecuencia en la cicatrización de heridas crónicas. Una revisión en hospital de media estancia.
Barbas Monjo, Miguel Ángel
Velasco García Cuevas, Jara
Rodríguez Lastra, Jesús
Cuenca Zaldívar, Juan Nicolás
Heridas crónicas
Radiofrecuencia
Pie diabético
Las heridas crónicas son un problema de salud significativo. Parece que la estimulación eléctrica produce una reducción significativamente mayor en el área de superficie y cicatrización más completa de las úlceras de difícil cicatrización y de evolución tórpida en comparación con la terapia habitual, sin vendaje compresivo.
Objetivos:
Evaluar el efecto que la radiofrecuencia a baja intensidad y con efectos no térmicos tiene sobre los diferentes componentes del mecanismo del proceso de cicatrización.
Metodología:
Para el tratamiento, se utilizó un dispositivo de tecarterapia (CAPENERGY C200). Se aplicaron un total de 10 sesiones de radiofrecuencia con una periodicidad de 1 vez a la semana con una potencia del 60% y una frecuencia de 1,2 MHz durante 30 minutos.
Resultados:
La presencia de edema, observada en todos los pacientes en la región de la extremidad inferior, desapareció en 30 de los 36 pacientes (Wilcoxon p = 0,004). Este resultado fue confirmado por ultrasonido. El edema celular subcutáneo medio disminuyó en 1,73 cm (Friedman p = 0,000). La temperatura del área tomada antes y después del tratamiento se incrementó en un promedio de 1,4 °C. Estas diferencias son estadísticamente significativas (Wilcoxon p = 0,000).
Conclusiones:
La radiofrecuencia parece que puede reducir el largo proceso de cicatrización de las lesiones de evolución tórpida, y nos encontramos con unas diferencias significativas a lo largo del tratamiento y con una reducción progresiva en las mediciones de las lesiones y mayor rapidez en la cicatrización de las heridas complejas.
post-print
319 KB
2022-05-23T09:15:52Z
2022-05-23T09:15:52Z
2021
article
1134-928X
http://hdl.handle.net/10641/2981
10.4321/s1134-928x2021000100013
spa
https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1134-928X2021000100063
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Gerokomos
oai:ddfv.ufv.es:10641/13652019-07-23T16:01:37Zcom_10641_132col_10641_1438
PrediCTC, liquid biopsy in precision oncology: a technology transfer experience in the Spanish health system.
Alonso Alconada, Lorena
Barbazan, Jorge
Candamio, Sonia
Falco, Josep Lluis
Antón Rodríguez, Cristina
Martín Saborido, Carlos
Fuster, Gustavo
Sampedro, Mabel
Grande, Carlos
Lado, Rubén
Sampietro Colom, Laura
Crego, Eladio
Figueiras, Sergio
León Mateos, Luis
López López, Rafael
Abal, Miguel
Liquid biopsy
Metastatic colorectal cancer
Regulatory roadmap
Benchmarking
Product development
Intellectual property
Cost-effectiveness
Expert panel
Purpose: Management of metastatic disease in oncology includes monitoring of therapy response principally by imaging techniques like CT-Scan. In addition to some limitations, the irruption of liquid biopsy and its application in personalized medicine has encouraged the development of more efficient technologies for prognosis and follow-up of patients in advanced disease.
Methods: PrediCTC constitutes a panel of genes for the assessment of Circulating Tumor Cells (CTC) in metastatic colorectal cancer patients, with demonstrated improved efficiency compared to CT-Scan for the evaluation of early therapy response in a multicenter prospective study. In this work, we designed and developed a technology transfer strategy to define the market opportunity for an eventual implementation of PrediCTC in the clinical practice.
Results: This included the definition of the regulatory framework, the analysis of the regulatory roadmap needed for CE mark, a benchmarking study, the design of a product development strategy, a revision of intellectual property, a cost-effectiveness study and an expert panel consultation.
Conclusion: The definition and analysis of an appropriate technology transfer strategy and the correct balance among regulatory, financial and technical determinants are critical for the transformation of a promising technology into a viable technology, and for the decision of implementing liquid biopsy in the monitoring of therapy response in advanced disease.
pre-print
533 KB
2017-11-17T07:56:29Z
2017-11-17T07:56:29Z
2017
article
1699-3055
http://hdl.handle.net/10641/1365
eng
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Clinical and Translational Oncology
oai:ddfv.ufv.es:10641/21022021-02-04T09:29:32Zcom_10641_252col_10641_1446
Una lectura girardiana de los sistemas totalitarios modernos: el caso de Cuba.
Rodríguez González, Raisiel Damián
Girard (1986) afirma que “en el totalitarismo moderno reaparece todo un conjunto de características primitivas”. Bajo esta línea de pensamiento se enmarca nuestro trabajo. Intentaremos realizar una lectura del totalitarismo que se fundó en la isla de Cuba en 1959 y ver cómo este se ha desarrollado. ¿Se pueden encontrar los elementos esenciales de los sistemas arcaicos sacrificiales en el interior del sistema totalitario cubano? Esta es la pregunta a la que buscaremos dar una respuesta.
post-print
2020-11-18T09:17:33Z
2020-11-18T09:17:33Z
2020
article
2603-6088
http://hdl.handle.net/10641/2102
10.32466/eufv-xg.2020.3.618.81-103
eng
https://portalderevistas.ufv.es/index.php/xgladius/article/view/618
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Universidad Francisco de Vitoria
oai:ddfv.ufv.es:10641/34272023-08-30T00:00:08Zcom_10641_132col_10641_1434
The effect of teacher leadership on students’ purposeful learning.
Fernández Espinosa, Verónica
López González, Jorge
Character education
Flourishing
High school students
Teacher leadership
Vulnerability
Teaching leadership is a key factor for students’ learning and flourishing, and it occurs in an asymmetrical and interpersonal relationship. This research seeks to characterize the teaching leadership of high school teachers through the influence they exert on their students. It is not based on the teacher’s self-perception but on the experience that the students have had. For this purpose, a qualitative study was carried out in Spain with 200 first-year university students in which they answered four questions about the teacher who most influenced them during their high school. The results point to five leadership traits or styles that are not mutually exclusive: empathetic leadership, comforting leadership, motivating leadership, exemplary leadership, and wise leadership. In addition, moments of weakness and vulnerability in students are those that most favour the influence of the teacher in their lives, encouraging vital learning in them. This study highlights the importance of teacher leadership for student character education.
post-print
1771 KB
2023-08-29T07:12:56Z
2023-08-29T07:12:56Z
2023
article
2331-1886
https://hdl.handle.net/10641/3427
10.1080/23311886.2023.2197282
eng
https://www.tandfonline.com/doi/full/10.1080/23311886.2023.2197282
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Cogent Social Sciences
oai:ddfv.ufv.es:10641/10362020-01-15T10:41:19Zcom_10641_252col_10641_1443
David Hume y la ciencia de la opinión.
Diez Álvarez, Luis Gonzalo
Pensamiento político
Educación política
Liberalismo
El David Hume objeto de este artículo no es el filósofo, sino el historiador y el pensador político. El
intelectual preocupado por la evolución histórica de las sociedades que pergeña, en su obra histórica
y ensayística, una teoría del proceso de la civilización construida con materiales propios de una
Ilustración liberal y escéptica. Dicha teoría no fue expuesta por Hume de manera sistemática, con lo
que el presente artículo trata de hacer explícita la unidad que subyace a las fragmentarias reflexiones
políticas, sociales y económicas del pensador escocés. Nuestra tesis es que dichas reflexiones obedecieron
a un fin estabilizador: el de asentar en Gran Bretaña el proceso civilizatorio tras la Revolución
de 1688 acabando con las disputas faccionalistas y contribuyendo a la creación de una ciudadanía
prudente y moderada, alejada de cualquier género de extremismo.
The “David Hume” purpose of this article is not the philosopher but the historian and political thinker. Intellectual concerned
about the historical evolution of societies that outlines in their historical and essays, a theory of the process of civilization
built with materials from a liberal and skeptical Enlightenment. This theory was not advanced by Hume systematically,
so this article is to make explicit the underlying unity to the fragmented political, social and economic considerations Scottish
thinker. Our thesis is that these discussions were due to a stabilizing purpose: to settle in Britain the civilizing process
after the Revolution of 1688 ending the factional disputes and contributing to the creation of a prudent and moderate
citizens, far from any kind of extremism.
post-print
295 KB
2014-11-26T09:54:45Z
2014-11-26T09:54:45Z
2014
article
1885-365X
http://hdl.handle.net/10641/1036
spa
Comunicación y Hombre, Nº 10
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Universidad Francisco de Vitoria
oai:ddfv.ufv.es:10641/39782024-02-14T01:00:14Zcom_10641_132col_10641_1423
Access to liver transplant for women in Spain: a national registry analysis.
Tejedor Bravo, Marta
Neria Serrano, Fernando
De la Rosa, Gloria
Almohalla Alvarez, Carolina
Boscá, Andrea
Fundora, Yilliam
Sánchez-Bueno, Francisco
Berenguer, Marina
Background and aims: Gender inequities in liver transplantation
(LT) have been documented recently in several studies. Providing
national data is crucial as poorer access to liver transplantation for
women than men might be explained by different analytical
approaches or different national contexts. Our aim was to describe
the recipient profile over time in Spain, particularly regarding
potential sex-related differences in access to LT.
Method: All adult patients registered in the RETH-Spanish Liver
Transplant Registry from 2000 to 2018 for LT were included. Baseline
demographics, presence of hepatocellular carcinoma (HCC), cause
and severity of liver disease, time on the waiting list (WL), access to
transplantation, and reasons for removal fromthe WL were assessed.
Results: 9427 patients were analyzed (77.6% men, 55.3 ± 8.6 years of
age). Mean MELD score was reported for 3404 patients (36.1%), and
was 16.5 ± 5.8. Women were less likely to receive a transplant than
men (OR 0.84, 95% CI 0.73, 0.97) and more likely to be excluded for
deterioration (HR 1.21, 95% CI 1.02, 1.44), despite similar liver disease
severity (MELD score 16.6 ± 5.8 vs 16.5 ± 5.8 respectively, N.S) and
only a slightly longer mean time on the WL (244 ± 398 days for
women vs 213 ± 324 for men, p = 0.001). In recent years, this
difference in access to LT was less significant (before 2011 women’s
HR for exclusionwas 1.51 [95% CI 1.01, 2.26] vs 1.17 [95% CI 0.97, 1.41]
after 2011) and could be attributed to overall shorter mean WL times
after 2011 (398 ± 602 vs 154 ± 217 days respectively, p < 0.001). When
analyzed by MELD, WL times were similar by sex for patients with
scores under 16 or above 20, but women had significantly longer
mean WL times than men with MELD scores 16–20 (270 ± 267 vs 211
± 207 days respectively, p < 0.001). Women were shorter (170.5 ± 9.7
vs 158.5 ± 9.8 cm) but had a similar BMI compared to men. Inwomen,
the main indications for transplant were cholestatic liver diseases,
autoimmune hepatitis and NASH, whilst in men it was alcohol (p <
0.001). Women had less HCC than men (27.1 vs 16.6%, p < 0.001).
Conclusion: Shorter WL times contribute to a more equal access to LT
by sex, as it prevents women from deteriorating while waiting and
therefore being excluded from the list.
post-print
1540 KB
2024-02-13T10:28:45Z
2024-02-13T10:28:45Z
2023
other
https://hdl.handle.net/10641/3978
10.1016/S0168-8278(23)01181-9
eng
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Journal of Hepatology
oai:ddfv.ufv.es:10641/6222019-07-23T16:23:04Zcom_10641_252col_10641_1444
José Juan Arrom y las raíces culturales antillanas
Hernández Sánchez-Barba, Mario
Arrom, Juan José-Crítica e interpretación
post-print
108,81 KB
2013-03-01T00:41:32Z
2013-03-01T00:41:32Z
2012
article
1134-7627
http://hdl.handle.net/10641/622
spa
Mar Océana, Nº 30
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Foro Hispanoamericano Francisco de Vitoria
Universidad Francisco de Vitoria
oai:ddfv.ufv.es:10641/5222021-03-25T11:09:26Zcom_10641_252col_10641_1444
La idea del hombre en el Poema del Cid
Sánchez Palencia, Ángel
Poema del Mío Cid
Antropología filosófica
Individuo-Filosofía
post-print
142 KB
2013-02-11T02:43:11Z
2013-02-11T02:43:11Z
2007
article
1134-7627
http://hdl.handle.net/10641/522
spa
Mar Océana, Nº 22
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Universidad Francisco de Vitoria
Foro Hispanoamericano Francisco de Vitoria
oai:ddfv.ufv.es:10641/37272024-02-28T11:49:35Zcom_10641_132col_10641_1424
Marca un ippon a tu evaluación.
Merino Fernández, María
Rodríguez Rodríguez, Bárbara
Alarcón Guerrero, Rafael
Moreno Heredero, Berta
pre-print
2024-01-16T07:46:24Z
2024-01-16T07:46:24Z
2022
bookPart
Innovación docente y prácticas educativas para una educación de calidad.
978-84-1377-920-1
https://hdl.handle.net/10641/3727
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
closedAccess
Dykinson
oai:ddfv.ufv.es:10641/7862019-07-23T16:17:28Zcom_10641_252col_10641_1444
Simón Bolívar: la oportunidad de Hispanoamérica en El general en su laberinto
Iglesias Berzal, Montserrat
García Márquez, Gabriel (1927-) El general en su laberinto
Crítica e interpretación
Bolivar, Simón (1783-1830)
post-print
2,67 MB
2013-04-22T06:35:46Z
2013-04-22T06:35:46Z
2004
article
1134-7627
http://hdl.handle.net/10641/786
spa
Mar Océana, Nº 16
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Centro Universitario Francisco de Vitoria
Asociación Francisco López de Gómara
oai:ddfv.ufv.es:10641/2932022-02-21T10:33:38Zcom_10641_132col_10641_1425
La opinión como argumento en los medios audiovisuales
Sánchez Rodríguez, Gabriel
Periodismo
Medios de comunicación
Interpretación
Opinión
2012-08-09T03:05:25Z
2012-08-09T03:05:25Z
2010-01-26T12:48:32Z
article
http://hdl.handle.net/10641/293
spa
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
oai:ddfv.ufv.es:10641/25282021-10-29T00:00:25Zcom_10641_132col_10641_1434
Elogio del fragmento. La casa de Pierre Zoelly para el escultor Peter Hächler en Lenzburg.
Ramos Alderete, Pablo
Pesqueira Calvo, Carlos
Zoelly, Hächler
fragmento
enigma
ruina
casa
escultura
Frente al objeto terminado, Zoelly se decanta por lo incompleto, por lo
fragmentario. Al mostrar tan solo una parte y un momento de la obra se sumerge
de lleno en una estética del fragmento, que carga de posibilidades lo mostrado,
escondiendo el final, pero abriendo la obra a infinitas interpretaciones. Como
si fuese una ruina inversa, Zoelly pretende, a partir de la evocación, mostrar su
confianza en que la arquitectura tiene un sentido mucho más allá de la mera
funcionalidad. La casa se presenta como enigma: símbolo de algo que no se sabe
qué es pero que está cargado de necesidad.
A través del análisis del modo de presentación elegido por Pierre Zoelly para
mostrar su obra en Elements of an architect’s language y de la propia casa
de Hächler se indaga en las razones y el pensamiento que llevaron a Zoelly a
presentar su obra inacabada, y en las relaciones que se tejen entre arquitecto
y escultor gracias, precisamente, a esa visión fragmentaria. Se pondrá de
manifiesto el valor del fragmento como clave del diálogo, y se presentará una
manera de entender la arquitectura en la que lo importante es la visión parcial.
post-print
897 KB
2021-10-28T08:07:00Z
2021-10-28T08:07:00Z
2020
article
2340-9711
http://hdl.handle.net/10641/2528
10.24192/2386-7027(2020)(v14)(12)
spa
http://ojs.redfundamentos.com/index.php/rita/article/view/531
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Revista indexada de textos académicos
oai:ddfv.ufv.es:10641/15622019-07-23T15:29:39Zcom_10641_132col_10641_1426
Experiencias de respuesta fiscal para el alojamiento colaborativo desde los contextos europeo y de la OCDE.
Calderón Corredor, Zulema
Alojamiento colaborativo
Fiscalidad
post-print
5550 KB
2019-01-30T12:29:01Z
2019-01-30T12:29:01Z
2017
article
1696-0173
http://hdl.handle.net/10641/1562
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Nueva fiscalidad
oai:ddfv.ufv.es:10641/28992022-03-23T01:00:20Zcom_10641_9col_10641_1402
Obsolescencia y regeneración urbana.
Garraye del Cerro, Rubén
pre-print
51384 KB
2022-03-22T09:31:32Z
2022-03-22T09:31:32Z
2018
bachelorThesis
http://hdl.handle.net/10641/2899
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
oai:ddfv.ufv.es:10641/28732023-05-10T10:37:15Zcom_10641_248col_10641_251
Memoria académica 2019/2020
Universidad Francisco de Vitoria
pre-print
32114 KB
2022-03-03T11:15:21Z
2022-03-03T11:15:21Z
2020
other
http://hdl.handle.net/10641/2873
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Universidad Francisco de Vitoria
oai:ddfv.ufv.es:10641/31912022-12-13T01:00:12Zcom_10641_132col_10641_1423
Lipid nanoparticles for antisense oligonucleotide gene interference into brain border-associated macrophages.
Calero, Macarena
Moleiro, Lara H.
Sayd, Aline
Dorca, Yeray
Miquel-Rio, Lluis
Paz, Verónica
Robledo-Montaña, Javier
Enciso, Eduardo
Acción, Fernando
Herráez Aguilar, Diego
Hellweg, Thomas
Sánchez, Luis
Bortolozzi, Analía
Leza, Juan C.
García-Bueno, Borja
Monroy, Francisco
Perivascular/meningeal macrophages
Lipidic nanoparticles
GapmeRs
L-PGDS gene
Neuroinflammation
A colloidal synthesis’ proof-of-concept based on the Bligh–Dyer emulsion inversion method was designed for integrating into lipid nanoparticles (LNPs) cell-permeating DNA antisense oligonucleotides (ASOs), also known as GapmeRs (GRs), for mRNA interference. The GR@LNPs were formulated to target brain border-associated macrophages (BAMs) as a central nervous system (CNS) therapy platform for silencing neuroinflammation-related genes. We specifically aim at inhibiting the expression of the gene encoding for lipocalin-type prostaglandin D synthase (L-PGDS), an anti-inflammatory enzyme expressed in BAMs, whose level of expression is altered in neuropsychopathologies such as depression and schizophrenia. The GR@LNPs are expected to demonstrate a bio-orthogonal genetic activity reacting with L-PGDS gene transcripts inside the living system without interfering with other genetic or biochemical circuitries. To facilitate selective BAM phagocytosis and avoid subsidiary absorption by other cells, they were functionalized with a mannosylated lipid as a specific MAN ligand for the mannose receptor presented by the macrophage surface. The GR@LNPs showed a high GR-packing density in a compact multilamellar configuration as structurally characterized by light scattering, zeta potential, and transmission electronic microscopy. As a preliminary biological evaluation of the mannosylated GR@LNP nanovectors into specifically targeted BAMs, we detected in vivo gene interference after brain delivery by intracerebroventricular injection (ICV) in Wistar rats subjected to gene therapy protocol. The results pave the way towards novel gene therapy platforms for advanced treatment of neuroinflammation-related pathologies with ASO@LNP nanovectors.
post-print
5375 KB
2022-12-12T13:10:10Z
2022-12-12T13:10:10Z
2022
article
2296-889X
https://hdl.handle.net/10641/3191
10.3389/fmolb.2022.887678
eng
https://www.frontiersin.org/articles/10.3389/fmolb.2022.887678/full
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Frontiers in Molecular Biosciences
oai:ddfv.ufv.es:10641/32472023-02-04T01:00:10Zcom_10641_132col_10641_1438
Usefulness of Serial Multiorgan Point-of-Care Ultrasound in Acute Heart Failure: Results from a Prospective Observational Cohort.
Torres-Arrese, Marta
García de Casasola-Sánchez, Gonzalo
Méndez-Bailón, Manuel
Montero-Hernández, Esther
Cobo-Marcos, Marta
Rivas-Lasarte, Mercedes
Caurcel-Díaz, Luis
Rodríguez-Fuertes, Pablo
Villén Villegas, Tomas
Tung-Chen, Yale
Acute heart failure
Venous congestion
Point-of-Care Ultrasound
Background and Objectives: Acute heart failure (AHF) is a common disease and a cause
of high morbidity and mortality, constituting a major health problem. The main purpose of this
study was to determine the impact of multiorgan ultrasound in identifying pulmonary hypertension
(PH), a major prognostic factor in patients admitted due to AHF, and assess whether there are
significant changes in the venous excess ultrasonography (VE US) score or femoral vein Doppler at
discharge. Materials and Methods: Patients were evaluated with a standard protocol of lung ultrasound,
echocardiography, inferior vena cava (IVC) and hepatic, portal, intra-renal and femoral vein Doppler
flow patterns at admission and on the day of discharge. Results: Thirty patients were enrolled during
November 2021. The mean age was seventy-nine years (Standard Deviation–SD 13.4). Seven patients
(23.3%) had a worsening renal function during hospitalization. Regarding ultrasound findings,
VE US score was calculated at admission and at discharge, unexpectedly remaining unchanged or
even worsened (21 patients, 70.0%). The area under the curve for the lung score was 83.9% (p = 0.008),
obtaining a cutoff value of 10 that showed a sensitivity of 82.6% and a specificity of 71.4% in the
identification of intermediate and high PH. It was possible to monitor significant changes between
both exams on the lung score (16.5 vs. 9.3; p < 0.001), improvement in the hepatic vein Doppler
pattern (2.4 vs. 2.1; p = 0.002), improvement in portal vein Doppler pattern (1.7 vs. 1.4; p = 0.023),
without significant changes in the intra-renal vein Doppler pattern (1.70 vs. 1.57; p = 0.293), VE US
score (1.3 vs. 1.1; p = 0.501), femoral vein Doppler pattern (2.4 vs. 2.1; p = 0.161) and IVC collapsibility
(2.0 vs. 2.1; p = 0.420). Conclusions: Our study results suggest that performing serial multiorgan
Point-of-Care ultrasound can help us to better identify high and intermediate probability of PH
patients with AHF. Currently proposed multi-organ, venous Doppler scanning protocols, such as the
VE US score, should be further studied before expanding its use in AHF patients.
post-print
2977 KB
2023-02-03T11:43:18Z
2023-02-03T11:43:18Z
2022
article
1648-9144
https://hdl.handle.net/10641/3247
10.3390/medicina58010124
eng
https://www.mdpi.com/1648-9144/58/1/124
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Medicina
oai:ddfv.ufv.es:10641/25192021-10-28T00:00:24Zcom_10641_132col_10641_1438
Physical activity and exercise: Strategies to manage frailty
Angulo, Javier
El Assar, Mariam
Álvarez-Bustos, Alejandro
Rodríguez Mañas, Leocadio
Aging
Frailty
Physical activity
Exercise
Oxidative stress
Multicomponent intervention
Frailty, a consequence of the interaction of the aging process and certain chronic diseases, compromises functional
outcomes in the elderly and substantially increases their risk for developing disabilities and other adverse
outcomes. Frailty follows from the combination of several impaired physiological mechanisms affecting multiple
organs and systems. And, though frailty and sarcopenia are related, they are two different conditions. Thus,
strategies to preserve or improve functional status should consider systemic function in addition to muscle
conditioning. Physical activity/exercise is considered one of the main strategies to counteract frailty-related
physical impairment in the elderly. Exercise reduces age-related oxidative damage and chronic inflammation,
increases autophagy, and improves mitochondrial function, myokine profile, insulin-like growth factor-1 (IGF-1)
signaling pathway, and insulin sensitivity. Exercise interventions target resistance (strength and power), aerobic,
balance, and flexibility work. Each type improves different aspects of physical functioning, though they could be
combined according to need and prescribed as a multicomponent intervention. Therefore, exercise intervention
programs should be prescribed based on an individual's physical functioning and adapted to the ensuing response.
pre-print
2.493 KB
2021-10-27T09:49:48Z
2021-10-27T09:49:48Z
2020
article
2213-2317
http://hdl.handle.net/10641/2519
10.1016/j.redox.2020.101513
eng
https://www.sciencedirect.com/science/article/pii/S2213231720301178?via%3Dihub
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Redox Biology
oai:ddfv.ufv.es:10641/29852022-05-27T00:00:20Zcom_10641_132col_10641_1434
Transhumanismo y deseo: una aproximación fenomenológica.
García Díaz, David
Transhumanismo
Deseo
En este artículo nos acercamos a comprender los presupuestos de la corriente transhumanista para reconocer algunas de las notas fundamentales y universales de la naturaleza humana que son manifestadas a través de sus propuestas. Desde los planteamientos del transhumanismo se puede reconocer al ser humano como un ser anhelante, un ser que naturalmente desea. Además, se reconoce que dicho deseo motiva la acción del hombre y que la persona se encuentra siempre en vías de perfeccionamiento, motivado a superar sin límites lo que la realidad le ofrece para colmar su deseo de plenitud. Asimismo, se analizan las principales propuestas de mejoramiento humano sostenidas desde el transhumanismo para comprender cuáles son los deseos del corazón del hombre que se manifiestan a través de ellas. El reconocimiento de estos deseos puede ser tomado como un buen punto de partida para el diálogo entre el transhumanismo y otras corrientes que reconocen el deseo como parte fundamental de la naturaleza de la persona. Juzgamos también si el transhumanismo puede comprenderse como una respuesta adecuada para satisfacer los anhelos más profundos del corazón humano de felicidad y plenitud, llegando a la conclusión de que las tesis transhumanistas son insuficientes a la hora de calmar las inquietudes fundamentales del corazón humano.
Abstract:
post-print
162 KB
2022-05-26T11:36:30Z
2022-05-26T11:36:30Z
2021
article
1132-1989
http://hdl.handle.net/10641/2985
10.30444/CB.95
spa
http://aebioetica.org/cuadernos-de-bioetica/archivo-on-line/2021/n%C2%BA-105-mayo-agosto.html
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Cuadernos de bioética
oai:ddfv.ufv.es:10641/15402023-12-15T08:05:45Zcom_10641_132col_10641_1430
Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.
Saravia, Rocío
Ten Blanco, Marc
Julià Hernández, Marina
Gagliano, Humberto
Andero, Raül
Armario, Antonio
Maldonado, Rafael
Berrendero, Fernando
Δ9-tetrahydrocannabinol
Stress
Adolescence
Fear extinction
Dendritic spines
Amygdala
Δ9-tetrahydrocannabinol (THC) consumption during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. The interaction between genetic or environmental events and cannabinoid exposure in the adolescent period can also contribute to exacerbate behavioural deficits in adulthood. Here we investigate the effects of THC treatment as well as the consequences of concomitant THC and stress exposure during adolescence in the extinction of fear memory in adult mice. Adolescent mice treated with THC and exposed to stress exhibit impaired cued fear extinction in adulthood. However, no effect was observed in animals exposed to these two factors separately. Notably, resistance to fear extinction was associated with decreased neuronal activity in the basolateral amygdala (BLA) and the infralimbic prefrontal cortex, suggesting a long-term dysregulation of the fear circuit. These changes in neuronal activation were paralleled with structural plasticity alterations. Indeed, an increase of immature dendritic spines in pyramidal neurons of the BLA was revealed in mice simultaneously exposed to THC and stress. Corticosterone levels were also enhanced after the cued fear conditioning session in the same experimental group. These results show that an interaction between cannabis exposure and stress during adolescence may lead to long-term anxiety disorders characterized by the presence of pathological fear.
pre-print
312 KB
2018-11-26T12:39:05Z
2018-11-26T12:39:05Z
2018
article
1873-7064
http://hdl.handle.net/10641/1540
10.1016/j.neuropharm.2018.11.016
eng
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Neuropharmacology
oai:ddfv.ufv.es:10641/19122021-02-04T09:24:45Zcom_10641_132col_10641_1438
Beneficial effects of paricalcitol on cardiac dysfunction and remodelling in a model of established heart failure.
Tamayo, María
Martín‐Nunes, Laura
Val‐Blasco, Almudena
Garcia Miguel Piedras, María José
Navarro García, José Alberto
Lage, Eduardo
Prieto, Patricia
Ruiz Hurtado, Gema
Fernández Velasco, María
Delgado, Carmen
Paricalcitol
K+ currents
Transverse aortic constriction
Heart failure
Electrophysiological remodelling
Ca2+ handling remodelling
Cardiac fibrosis
Background and Purpose
The synthetic vitamin D3 analog paricalcitol acts as a selective activator of vitamin D receptor (VDR). While there is evidence for cardioprotective effects of paricalcitol associated with the VDR pathway, less information is available about the structural and functional cardiac effects of paricalcitol on established heart failure (HF), and particularly its effects on associated electrophysiological or Ca2+-handling remodelling.
Experimental Approach
We used a murine model of transverse aortic constriction (TAC) to study the effect of paricalcitol on established HF. Treatment was initiated 4 weeks after surgery over 5 consecutive weeks and mice were sacrificed 9 weeks after surgery. Cardiac magnetic resonance imaging (CMRI) was performed 4 and 9 weeks after surgery. Hearts were used for biochemical and histological studies and to isolate ventricular myocytes for electrophysiological and calcium imaging studies.
Key Results
CMRI analysis revealed that, compared with vehicle, paricalcitol treatment prevented the progression of ventricular dilation and hypertrophy after TAC and halted the corresponding decline in ejection fraction. These beneficial effects were related to the attenuation of intracellular Ca2+-mishandling remodelling, antifibrotic and antihypertrophic effects, and potentially antiarrhythmic effects by preventing the reduction of K+ current density and the long QT, JT and TpTe intervals observed in HF animals.
Conclusions and implications
The results suggest that paricalcitol treatment in established HF hampers disease progression and improves adverse electrophysiological and Ca2+ handling remodelling, attenuating the vulnerability to HF-associated ventricular arrhythmias. Paricalcitol may emerge as a potential therapeutic option in the treatment of HF.
pre-print
533 KB
2020-05-07T16:48:14Z
2020-05-07T16:48:14Z
2020
article
1476-5381
http://hdl.handle.net/10641/1912
10.1111/bph.15048
eng
https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.15048
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
British Journal of Pharmacology
oai:ddfv.ufv.es:10641/23952021-08-25T00:00:29Zcom_10641_132col_10641_1438
Subjective assessment reported by patients shows differences between single-bundle and double-bundle anterior cruciate ligament reconstruction, systematic review and meta-analysis.
Maestro, Antonio
Herruzo Priego, Irene
Varillas Delgado, David
Martín Saborido, Carlos
To determine the functional recovery, active reincorporation, and anteroposterior and rotational stability of patients undergoing anterior cruciate ligament (ACL) reconstruction using arthroscopy techniques with simple-bundle (SB) or double-bundle (DB). The following databases were searched: PubMed, Embase (Elsevier platform), the Cochrane Central Register of Controlled Trials (Wiley platform), Web of Science, and CINAHL. Level I and II studies involving anterior cruciate ligament arthroscopy were included in the search. Records were screened by title and abstract and assessed the risk of bias of selected studies. Meta-analyses using RevMan 5.3 software were conducted on the following outcomes: knee functionality, objective measurements of knee stability, rotational knee stability and knee anterior stability, sports reincorporation, and subjective assessments. Twenty-four studies of patients undergoing ACL reconstruction were included in the qualitative and quantitative synthesis (1707 patients) for Lysholm score, Subjective International Knee Documentation Committee (IKDC) score, Tegner score, KT-1000/2000, Lachman test, Objective IKDC score, and Pivot-Shift test. A return to pre-injury level showed a significant decrease in the Lysholm score (mean difference, − 0.99; 95% CI − 1.71 to − 0.40; P = 0.007) and Tegner score (mean difference, − 0.07; 95% CI, − 0.13 to − 0.01; P = 0.02) at DB reconstruction, similar to the knee functionality outcome of the subjective IKDC score (mean difference − 1.42; 95% CI − 2.46 to − 0.38; P = 0.007). There is no clear or significant difference in clinical stability and knee function or in sports incorporation with the true difference occurring in the subjective assessment.
post-print
3808 KB
2021-08-24T11:21:27Z
2021-08-24T11:21:27Z
2021
article
2045-2322
http://hdl.handle.net/10641/2395
10.1038/s41598-021-94868-0
eng
https://www.nature.com/articles/s41598-021-94868-0
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Scientific Reports
oai:ddfv.ufv.es:10641/29312022-04-26T00:00:23Zcom_10641_132col_10641_1438
Advances of Genomic Medicine in Psoriatic Arthritis.
Laborde, Carlos M.
Larzabal, Leyre
González-Cantero, Álvaro
Castro-Santos, Patricia
Díaz-Peña, Roberto
Psoriatic arthritis
Spondyloarthropathies
Personalized medicine
Genomics
Genomewide association studies
Transcriptomics
Epigenomics
Psoriatic arthritis (PsA) is a common type of inflammatory arthritis found in up to 40% of
patients with psoriasis. Although early diagnosis is important for reducing the risk of irreversible
structural damage, there are no adequate screening tools for this purpose, and there are no clear
markers of predisposition to the disease. Much evidence indicates that PsA disorder is complex and
heterogeneous, where genetic and environmental factors converge to trigger inflammatory events
and the development of the disease. Nevertheless, the etiologic events that underlie PsA are complex
and not completely understood. In this review, we describe the existing data in PsA in order to
highlight the need for further research in this disease to progress in the knowledge of its pathobiology
and to obtain early diagnosis tools for these patients.
post-print
536 KB
2022-04-25T10:07:01Z
2022-04-25T10:07:01Z
2022
article
2075-4426
http://hdl.handle.net/10641/2931
10.3390/jpm12010035
eng
https://www.mdpi.com/2075-4426/12/1/35
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Journal of Personalized Medicine
oai:ddfv.ufv.es:10641/21762022-01-27T08:53:50Zcom_10641_132col_10641_1428
What Do Secondary Education Students Understand About Social Justice? Students Representations of Social Justice in Different Regions of Spain.
Sáinz López, Vanesa
Jacott, Liliana
Social Justice
Education
Redistribution
Recognition
Representation
This quantitative empirical research analyses secondary school students’ representations of social justice in different regions of Spain. ‘Social Justice Representation Questionnaire- SJRQ’ has been designed and implemented to conduct an empirical analysis of Social Justice in the field of education. This instrument is based on the three dimensional model of social justice (redistribution, recognition and representation). Participants of this study were 3229 secondary education students from 12 to 21 years old. The participants belong to 20 public schools in five Autonomous Communities of Spain. This study aims to determine how the concept of social justice develops in secondary education students of different educational levels and whether gender is a relevant variable. The results confirm that social justice representations of secondary education students follow a developmental trend because students of upper educational levels have a closer vision to social justice. Also, females manifest a greater predisposition towards social justice than males. This study confirm that SJRQ is a useful tool to train Social Justice oriented citizens and to develop training programs adapted to different understanding levels.
pre-print
623 KB
2021-01-14T15:15:03Z
2021-01-14T15:15:03Z
2020
article
0826-4805
http://hdl.handle.net/10641/2176
10.1007/s10780-020-09389-y
eng
https://link.springer.com/article/10.1007/s10780-020-09389-y
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Interchange
oai:ddfv.ufv.es:10641/27292022-01-27T01:00:46Zcom_10641_1919col_10641_1920
RM de cuerpo completo con secuencias de difusión para el estudio del cáncer ginecológico avanzado: Capacidad diagnóstica y predicción de la carga tumoral.
García Prado, Francisco Javier
Chiva de Agustín, José Luis
González Hernando, Concepción
Doctorado en Biotecnología, Medicina y Ciencias Biosanitarias
Los tumores malignos de origen ginecológico presentan diferentes vías de diseminación según su origen. Así, los cánceres de cuerpo y cérvix uterino se diseminan regionalmente de forma local y ganglionar y, de manera tardía, por el peritoneo como carcinomatosis peritoneal (CP). El cáncer de cérvix es el tumor ginecológico más frecuente en el mundo relacionado con el virus del papiloma humano (VPH), y el de cuerpo uterino lo es en países industrializados, en relación con factores de riesgo conocidos. El cáncer de ovario (CO) es la causa más frecuente de mortalidad en el cáncer ginecológico en países desarrollados.
La resección completa de la CP es el mejor factor pronóstico de supervivencia en CO avanzado. La técnica de elección para la evaluación de la cavidad abdominal es la tomografía computarizada (TC), aunque su capacidad diagnóstica para predecir el éxito de la citorreducción es limitada. La tomografía por emisión de positrones (PET/TC) es la técnica de elección en el estudio a distancia del cáncer de cérvix, aunque no lo es en el CO. La CP se muestra como focos de elevada señal en las secuencias de difusión (DW) en resonancia (RM). Objetivos:
Comparar la técnica de la RM de cuerpo completo con imágenes potenciadas en difusión con supresión del fondo (whole-body DW imaging with background suppression MRI (WB-DWIBS/MRI) con los hallazgos quirúrgicos y su confirmación histológica.
Estudiar la correlación de la carga total tumoral predicha con la WB-DWIBS/MRI, esto es, Peritoneal Cancer Index (PCI) + Retroperitoneal Cancer Index (RCI), en comparación con la obtenida con la cirugía y con el CA125, marcador tumoral del CO.
Determinar la capacidad diagnóstica y la capacidad de predicción de la carga tumoral quirúrgica predicha siguiendo la metodología PCI descrita por Sugarbaker para la CP.Valorar la capacidad diagnóstica y la capacidad de predicción de la carga tumoral ganglionar mediante la técnica RCIde forma análoga al PCI.
pre-print
7985 KB
2022-01-26T10:44:04Z
2022-01-26T10:44:04Z
2021
doctoralThesis
http://hdl.handle.net/10641/2729
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
oai:ddfv.ufv.es:10641/16242019-07-23T15:25:35Zcom_10641_132col_10641_1423
Sustained Human Hair Follicle Growth Ex Vivo in a Glycosaminoglycan Hydrogel Matrix.
Fernández Martos, Sandra
Calvo Sánchez, María Inmaculada
García Alonso, Karla
Castro, Begoña
Hashtroody, Bita
Espada, Jesús
Glycosaminoglycans
Hyaluronic acid
Stem cells
Human hair follicl
Glycosaminoglycans (GAGs) and associated proteoglycans have important functions in
homeostatic maintenance and regenerative processes (e.g., wound repair) of the skin. However,
little is known about the role of these molecules in the regulation of the hair follicle cycle. Here we
report that growing human hair follicles ex vivo in a defined GAG hydrogel mimicking the dermal
matrix strongly promotes sustained cell survival and maintenance of a highly proliferative
phenotype in the hair bulb and suprabulbar regions. This significant effect is associated with the
activation of WNT/β-catenin signaling targets (CCDN1, AXIN2) and with the expression of stem
cell markers (CK15, CD34) and growth factors implicated in the telogen/anagen transition (TGFβ2,
FGF10). As a whole, these results point to the dermal GAG matrix as an important component in
the regulation of the human hair follicle growth cycle, and to GAG-based hydrogels as potentially
relevant modulators of this process both in vitro and in vivo.
post-print
4320 KB
2019-04-22T11:14:21Z
2019-04-22T11:14:21Z
2019
article
1661-6596
http://hdl.handle.net/10641/1624
10.3390/ijms20071741
eng
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
International Journal of Molecular Sciences
oai:ddfv.ufv.es:10641/27542022-02-02T01:00:18Zcom_10641_132col_10641_1431
Effects of acute caffeine ingestion on futsal performance in sub-elite players.
López Samanés, Álvaro
Moreno Pérez, Víctor
Travassos, Bruno
Del Coso, Juan
Team sports
Sports nutrition
External load
Sports performance
Purpose
To date, no previous investigation has studied the effect of acute caffeine ingestion on futsal performance during futsal-specific testing and during a simulated match. Therefore, the aim of this investigation was to establish the effects of acute caffeine intake on futsal-specific tests and match-play running performance in male futsal players.
Methods
Sixteen high-performance futsal players participated in a randomized, crossover, placebo-controlled and double-blind experiment. Each player completed two identical trials after ingesting either caffeine (3 mg/kg) or a placebo (cellulose). The trials consisted of a battery of futsal-specific tests (countermovement jump, 20-m sprint test, and a futsal kicking velocity and accuracy test) followed by a simulated futsal match (2 halves of 7.5 min). During the match, players’ running performance was assessed with local positioning system devices.
Results
In comparison to the placebo, caffeine ingestion increased jump height by 2.8% (p = 0.048; ES = 0.29) and reduced the time to complete the 20-m sprint test by -2.2% (p = 0.044; ES = − 0.54). Additionally, acute caffeine intake improved the distance covered at above 14.4 km/h by 19.6% (p = 0.021; ES = 0.58), the number of body impacts by 8.1% (p = 0.040; ES = 0.27) and the number of accelerations/decelerations by 4.2% (p = 0.044; ES = 0.57) during the simulated futsal match. However, no differences were reported in ball velocity or shooting accuracy in the futsal kicking test. There were no differences in the prevalence of side effects reported in the hours after the ingestion of the treatments.
Conclusion
Three mg/kg of caffeine enhanced several physical variables associated with futsal such as jump and sprint performance, and improved high-speed running and accelerations/decelerations during a simulated futsal match. Caffeine supplementation with a moderate dose can be considered as an effective ergogenic aid for futsal performance with low prevalence of side effects.
pre-print
920 KB
2022-02-01T07:39:59Z
2022-02-01T07:39:59Z
2021
article
1436-6207
http://hdl.handle.net/10641/2754
10.1007/s00394-021-02617-w
eng
https://link.springer.com/article/10.1007/s00394-021-02617-w
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
European Journal of Nutrition volume
oai:ddfv.ufv.es:10641/6532019-07-23T16:21:17Zcom_10641_252col_10641_1444
Bécquer desde Veruela
Domínguez Lasierra, Juan
Bécquer, Gustavo Adolfo
post-print
1,00 MB
2013-03-15T03:32:29Z
2013-03-15T03:32:29Z
1999
article
1134-7627
http://hdl.handle.net/10641/653
spa
Mar Océana, Nº 03
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Asociación Francisco López de Gómara
oai:ddfv.ufv.es:10641/9852019-07-23T15:38:57Zcom_10641_132col_10641_1434
El mercado global requiere una ética global.
Parada Rodríguez, José Luis
Ética
2014-06-24T10:26:28Z
2014-06-24T10:26:28Z
2013
article
http://hdl.handle.net/10641/985
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Revista Ethic, 12
oai:ddfv.ufv.es:10641/38422024-02-01T01:00:12Zcom_10641_132col_10641_1441
The Relationship between Binge Drinking and Binge Eating in Adolescence and Youth: A Systematic Review and Meta-Analysis.
Sampedro-Piquero, Patricia
Zancada-Menéndez, Clara
Bernabeu Brotons, Elena
Moreno Fernández, Román Darío
Adolescence
Alcohol
Binge drinking
Binge eating
Emotional eating
Meta-analysis
Youth
Adolescence and youth are critical periods in which alcohol consumption is usually initiated, especially in the form of binge drinking. In recent years, it is increasingly common to find adolescents and young people who also present binge behaviors towards unhealthy food with the aim of alleviating their anxiety (emotional eating) and/or because of impulsive personality. Despite the social and health relevance of this issue, it remains scarcely studied and more preventive research needs to be developed. Our meta-analysis study aimed to evaluate the relationship and co-occurrence of both binge behaviors during adolescence and young adulthood to clarify the link between binge drinking and eating. Selective literature search on different online databases was performed. We identified discrete but significant results regarding the direct association between binge drinking and binge eating in correlation coefficients and odds ratio. Future research should focus on the common psychological background and motives behind these problematic behaviors owing to their clinical implications for effective prevention and treatment.
post-print
2,31 MB
2024-01-31T10:35:53Z
2024-01-31T10:35:53Z
2022
article
1660-4601
https://hdl.handle.net/10641/3842
10.3390/ijerph20010232
eng
https://www.mdpi.com/1660-4601/20/1/232
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
International Journal of Environmental Research and Public Health
oai:ddfv.ufv.es:10641/19562021-03-24T09:54:23Zcom_10641_132col_10641_1801
Exchange rate dynamics in South Africa.
Boateng, Alexander
Claudio Quiroga, Gloria
Gil Alana, Luis A.
Exchange rate dynamics
Long memory
South Africa
The structure of the nominal exchange rates in South Africa is examined by using fractional integration. We investigate the levels and the volatilities against the US dollar, the British pound, the Euro, the Japanese yen, the Chinese yuan, the Australian dollar, and the Botswanan pula. The results indicate that most series are unit root, I(1) and though there is some evidence of mean reversion, the orders of integration are close to 1, implying high levels of persistence. However, there is evidence of mean reversion for Bostwana Pula in various subsamples. For the volatilities, the stationary long memory is observed in all cases.
pre-print
521 KB
2020-07-20T11:41:57Z
2020-07-20T11:41:57Z
2020
article
0003-6846
http://hdl.handle.net/10641/1956
10.1080/00036846.2019.1688245
eng
https://www.tandfonline.com/doi/full/10.1080/00036846.2019.1688245
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Applied Economics
oai:ddfv.ufv.es:10641/28742023-05-10T10:37:49Zcom_10641_248col_10641_251
Memoria académica 2020/2021
Universidad Francisco de Vitoria
pre-print
21248 KB
2022-03-03T11:16:16Z
2022-03-03T11:16:16Z
2021
other
http://hdl.handle.net/10641/2874
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Universidad Francisco de Vitoria
oai:ddfv.ufv.es:10641/25202021-10-28T00:00:25Zcom_10641_132col_10641_1434
Carlos V e Isabel: Imperatorum Itinera.
Möller Recondo, Claudia
Jiménez Zamora, Isidoro
Viajes
Corte
Carlos V
Isabel de Portugal
España
Se presentan los resultados parciales de una investigación sobre los viajes realizados por Carlos V e Isabel de Portugal con el fin de mostrar de otra manera a la España imperial y de ver cómo se movía el poder. Este trabajo comienza en Sevilla, el 10 de marzo de 1526 (durante la boda) y termina en Toledo, el 1 de mayo de 1539 (cuando muere la Emperatriz). Hemos elaborado una periodización de los viajes conjuntos, que son de nuestro especial interés, pero también hemos trabajado en aquellos en los que, aun estando ambos en España, no realizaron en común.
pre-print
4.539 KB
2021-10-27T10:16:07Z
2021-10-27T10:16:07Z
2020
article
0210-9425
http://hdl.handle.net/10641/2520
10.24197/ihemc.40.2020.175-214
spa
https://revistas.uva.es/index.php/invehisto/article/view/3488
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Investigaciones históricas, época moderna y contemporánea
oai:ddfv.ufv.es:10641/16072019-07-23T15:54:24Zcom_10641_132col_10641_1438
Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment.
Sen, Sayan
Ahmad, Yousif
Dehbi, Hakim-Moulay
Alegría Barrero, Eduardo
BACKGROUND Physicians are not always comfortable deferring treatment of a stenosis in the left anterior descending
(LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors
describe, using the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation)
trial, MACE rates when LAD lesions are deferred, guided by physiological assessment using fractional flow reserve (FFR)
or the instantaneous wave-free ratio (iFR).
OBJECTIVES The purpose of this study was to establish the safety of deferring treatment in the LAD using FFR or iFR
within the DEFINE-FLAIR trial.
METHODS MACE rates at 1 year were compared between groups (iFR and FFR) in patients whose physiological
assessment led to LAD lesions being deferred. MACE was defined as a composite of cardiovascular death, myocardial
infarction (MI), and unplanned revascularization at 1 year. Patients, and staff performing follow-up, were blinded to
whether the decision was made with FFR or iFR. Outcomes were adjusted for age and sex.
RESULTS A total of 872 patients had lesions deferred in the LAD (421 guided by FFR, 451 guided by iFR). The event rate
with iFR was significantly lower than with FFR (2.44% vs. 5.26%; adjusted HR: 0.46; 95% confidence interval [CI]: 0.22
to 0.95; p ¼ 0.04). This was driven by significantly lower unplanned revascularization with iFR and numerically lower MI
(unplanned revascularization: 2.22% iFR vs. 4.99% FFR; adjusted HR: 0.44; 95% CI: 0.21 to 0.93; p ¼ 0.03; MI: 0.44%
iFR vs. 2.14% FFR; adjusted HR: 0.23; 95% CI: 0.05 to 1.07; p ¼ 0.06).
CONCLUSIONS iFR-guided deferral appears to be safe for patients with LAD lesions. Patients in whom
iFR-guided deferral was performed had statistically significantly lower event rates than those with
FFR-guided deferral.
post-print
445 KB
2019-04-09T08:52:28Z
2019-04-09T08:52:28Z
2019
article
0735-1097
http://hdl.handle.net/10641/1607
https://doi.org/10.1016/j.jacc.2018.10.070
eng
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Journal of the American College of Cardiology
oai:ddfv.ufv.es:10641/38312024-01-30T01:00:10Zcom_10641_132col_10641_1438
Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction.
Paz-García, Marta
Povo-Retana, Adrián
Jaén, Rafael I.
Prieto, Patricia
Peraza, Diego A.
Zaragoza Sánchez, Carlos
Hernández Jiménez, Macarena
Pineiro, David
Regadera, Javier
García-Bermejo, María L.
Rodríguez-Serrano, E. Macarena
Sánchez García, Sergio
Moro, María Ángeles
Lizasoaín, Ignacio
Delgado, Carmen
Valenzuela, Carmen
Boscá, Lisardo
ApTOLL
Aptamer
Inflammation
Ischemia/reperfusion
Myocardial infarction
TLR4
Experimental evidence indicates that the control of the inflammatory response after myocardial infarction is a key strategy to reduce cardiac injury. Cellular damage after blood flow restoration in the heart promotes sterile inflammation through the release of molecules that activate pattern recognition receptors, among which TLR4 is the most prominent. Transient regulation of TLR4 activity has been considered one of the potential therapeutic interventions with greater projection towards the clinic. In this regard, the characterization of an aptamer (4FT) that acts as a selective antagonist for human TLR4 has been investigated in isolated macrophages from different species and in a rat model of cardiac ischemia/reperfusion (I/R). The binding kinetics and biological responses of murine and human macrophages treated with 4FT show great affinity and significant inhibition of TLR4 signaling including the NF-κB pathway and the LPS-dependent increase in the plasma membrane currents (Kv currents). In the rat model of I/R, administration of 4FT following reoxygenation shows amelioration of cardiac injury function and markers, a process that is significantly enhanced when the second dose of 4FT is administered 24 h after reperfusion of the heart. Parameters such as cardiac injury biomarkers, infiltration of circulating inflammatory cells, and the expression of genes associated with the inflammatory onset are significantly reduced. In addition, the expression of anti-inflammatory genes, such as IL-10, and pro-resolution molecules, such as resolvin D1 are enhanced after 4FT administration. These results indicate that targeting TLR4 with 4FT offers new therapeutic opportunities to prevent cardiac dysfunction after infarction.
post-print
1,60 MB
2024-01-29T09:46:20Z
2024-01-29T09:46:20Z
2023
article
0753-3322
https://hdl.handle.net/10641/3831
10.1016/j.biopha.2023.114214
eng
https://www.sciencedirect.com/science/article/pii/S0753332223000021?via%3Dihub
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Biomedicine & Pharmacotherapy
oai:ddfv.ufv.es:10641/38042024-02-28T12:23:38Zcom_10641_132col_10641_1438
Trastuzumab Associated with Successive Cytotoxic Therapies Beyond Disease Progression in Metastatic Breast Cancer.
García-Sáenz, José A.
Martín, Miguel
Puente, Javier
López-Tarruella, Sara
Casado, Antonio
Moreno, Fernando
Grande-Pulido, E.
Díaz-Rubio, E.
Chemotherapy
HER2
Fluorescence in situ hybridization
Immunohistochemistry
Predictive factors
Purpose
To determine the activity of successive trastuzumab-containing regimens in HER2-overexpressing metastatic breast cancer (MBC) as well as the response rate (RR), time to progression (TTP), and predictive factors for response.
Patients and Methods
We performed a descriptive retrospective study of trastuzumab activity in patients with HER2-overexpressing MBC treated at our hospital from October 1999 to October 2003.
Results
Fifty-eight patients were evaluated, in whom an overall RR (complete response plus partial response) of 39.7% was obtained for first-time administration of trastuzumab; stable disease (SD) was seen in 29.3%, and the clinical benefit rate was 69%. Median TTP was 6 months (range, 1 months to > 39 months). A total of 31 patients (53.4%) received a second trastuzumab-containing regimen, with an RR of 25.8%; SD was seen in 12.9%, and the clinical benefit rate was 38.7%. Median TTP was 3 months (range, 1 months to > 22 months). A total of 8 patients (14.3%) received a third trastuzumab-containing regimen. The RR for the third trastuzumab regimen was 12.5%; SD was seen in 12.5%, and the clinical benefit rate was 25%. Median TTP was 2 months (range, 1 months to > 12 months). A total of 4 patients (7.1%) received a fourth trastuzumab-containing regimen, with an RR of zero and SD in 25%. Predictive factors for response were disease in soft tissue or bone (P = 0.03; odds ratio [OR], 3.25; 95% confidence interval [CI], 1.08–9.8) and metastases at > 2 sites (P = 0.03; OR, 6.2; 95% CI, 1.25–30.9). We observed a better RR in the second trastuzumab-containing regimen when the patient responded to the first regimen (P = 0.03; OR, 13.2; 95% CI, 1.36–126).
Conclusion
Trastuzumab-containing regimens beyond disease progression in MBC show activity even in heavily pretreated patients. The activity noted does not allow us to ascertain the independent contribution of trastuzumab in this setting. There were more responses in patients with few metastases in the soft tissues or bone. Patients who have shown a previous response to trastuzumab can show a response to a second trastuzumab-containing regimen.
pre-print
237 KB
2024-01-23T12:32:06Z
2024-01-23T12:32:06Z
2005
article
1938-0666
https://hdl.handle.net/10641/3804
10.3816/CBC.2005.n.035
eng
https://www.clinical-breast-cancer.com/article/S1526-8209(11)70851-5/pdf
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
closedAccess
Clinical breast cancer
oai:ddfv.ufv.es:10641/40352024-02-17T01:00:10Zcom_10641_132col_10641_1425
Metaphorical value in the narrative of a conversion: The sacred and profane memoirs of Captain Charles Ryder in Brideshead Revisited by Evelyn Waugh.
Hernández Ruiz, María Victoria
Conversion
Literary theory
Metaphor
Brideshead Revisited
Ordinary language has difficulty transmitting certain spiritual experiences, such as mystical ecstasy or the process of conversion. These experiences, which cannot be expressed in words, and which involve both the spiritual and the corporeal, are called ineffable. But the literary tradition is full of examples in which these incommunicable truths are expressed linguistically: from St. Augustine to C.S. Lewis, from St. John of the Cross to John Henry Newman, many authors have expressed their mystical or conversion experiences through metaphor. Evelyn Waugh’s novel Brideshead Revisited presents the action of divine grace on the characters, as seen through the eyes of the narrator as he undergoes his conversion. The intention of this article is to discover how the use of metaphor succeeds in expressing the action of divine grace in a conversion, providing important insights into the way poetic language can communicate the ineffable experience of the intimate encounter with divinity. To this end, the article analyses three metaphors of novel, (the twitch upon the thread, the balking horse and the hut collapsing under the avalanche) taking into consideration literary theory and what it says about metaphor.
post-print
1539 KB
2024-02-16T12:40:49Z
2024-02-16T12:40:49Z
2023
article
2375-3234
https://hdl.handle.net/10641/4035
10.1080/23753234.2023.2239288
eng
https://www.tandfonline.com/doi/full/10.1080/23753234.2023.2239288
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Church, Communication and Culture
oai:ddfv.ufv.es:10641/33602023-05-27T22:00:12Zcom_10641_1919col_10641_1921oai:ddfv.ufv.es:10641/32832023-03-30T22:00:11Zcom_10641_1919col_10641_1921oai:ddfv.ufv.es:10641/6622019-07-23T16:21:23Zcom_10641_252col_10641_1444
Propiedades materiales: herencia y vínculos afectivos
Escartín Alcubierre, Carmen
Relaciones humanas
post-print
1,27 MB
2013-03-19T07:48:17Z
2013-03-19T07:48:17Z
1999
article
1134-7627
http://hdl.handle.net/10641/662
spa
Mar Océana, Nº 03
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Asociación Francisco López de Gómara
oai:ddfv.ufv.es:10641/6052019-07-23T16:22:43Zcom_10641_252col_10641_1444
La prudencia
Estrada, José Ramón
Prudencia
Virtudes
Filosofía cristiana
post-print
176,09 KB
2013-02-26T04:03:38Z
2013-02-26T04:03:38Z
2011
article
1134-7627
http://hdl.handle.net/10641/605
spa
Mar Océana, Nº 29
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Foro Hispanoamericano Francisco de Vitoria
Universidad Francisco de Vitoria
oai:ddfv.ufv.es:10641/22802021-04-09T09:09:00Zcom_10641_252col_10641_1443
Sensibilidad y rigor en la traducción: la autonimia como solución apelativa.
Pourmazaheri, Afsaneh
Autonimia
Designación
¿Cómo procede un redactor de relatos de viajes cuando tiene que evocar un universo de referencia fundamentalmente heterogéneo a la lengua que comparte con sus lectores, para nombrar los referentes que no han recibido un nombre en esa lengua? A veces, el autor estima que su lector es capaz de tratar este tipo de texto, mientras que la estimación realizada es totalmente errónea y culmina en una ruptura de la comprensión por parte del lector. Esto ocurre principalmente cuando el referente textual se aleja del referente real. El distanciamiento o acercamiento cognitivo y semántico se analizan a nivel de las palabras extranjeras no aplicadas, pero que en ocasiones pueden adaptarse perfectamente al mundo del receptor con la ayuda de estrategias implementadas por el autor, sobre todo gracias a la autonimia, que analizaremos atentamente. Para nosotros se trata de estudiar, dentro de una perspectiva semánticodiscursiva, los distintos procesos (autonímicos) que permiten al redactor describir el referente exótico a partir de un corpus restringido de textos de viajeros franceses en Persia.
post-print
2021-04-09T09:08:34Z
2021-04-09T09:08:34Z
2019
article
1885-365X
http://hdl.handle.net/10641/2280
10.32466/eufv-cyh.2019.15.379.23-37
spa
https://portalderevistas.ufv.es/index.php/comunicacionyhombre/article/view/379
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Universidad Francisco de Vitoria
oai:ddfv.ufv.es:10641/41102024-02-27T01:00:10Zcom_10641_132col_10641_1438
Traumatic stress symptoms among Spanish healthcare workers during the COVID-19 pandemic: a prospective study.
Portillo-Van Diest, Ana
Vilagut, Gemma
Alayo, Itxaso
Molina Martín, Juan D.
Mortier, Philippe
COVID-19
Health personnel
Prospective cohort study
Traumatic stress
Aim
To investigate the occurrence of traumatic stress symptoms (TSS) among healthcare workers active during the COVID-19 pandemic and to obtain insight as to which pandemic-related stressful experiences are associated with onset and persistence of traumatic stress.
Methods
This is a multicenter prospective cohort study. Spanish healthcare workers (N = 4,809) participated at an initial assessment (i.e., just after the first wave of the Spain COVID-19 pandemic) and at a 4-month follow-up assessment using web-based surveys. Logistic regression investigated associations of 19 pandemic-related stressful experiences across four domains (infection-related, work-related, health-related and financial) with TSS prevalence, incidence and persistence, including simulations of population attributable risk proportions (PARP).
Results
Thirty-day TSS prevalence at T1 was 22.1%. Four-month incidence and persistence were 11.6% and 54.2%, respectively. Auxiliary nurses had highest rates of TSS prevalence (35.1%) and incidence (16.1%). All 19 pandemic-related stressful experiences under study were associated with TSS prevalence or incidence, especially experiences from the domains of health-related (PARP range 88.4–95.6%) and work-related stressful experiences (PARP range 76.8–86.5%). Nine stressful experiences were also associated with TSS persistence, of which having patient(s) in care who died from COVID-19 had the strongest association. This association remained significant after adjusting for co-occurring depression and anxiety.
Conclusions
TSSs among Spanish healthcare workers active during the COVID-19 pandemic are common and associated with various pandemic-related stressful experiences. Future research should investigate if these stressful experiences represent truly traumatic experiences and carry risk for the development of post-traumatic stress disorder.
post-print
374 KB
2024-02-26T11:13:22Z
2024-02-26T11:13:22Z
2023
article
2045-7960
https://hdl.handle.net/10641/4110
10.1017/S2045796023000628
eng
https://www.cambridge.org/core/journals/epidemiology-and-psychiatric-sciences/article/traumatic-stress-symptoms-among-spanish-healthcare-workers-during-the-covid19-pandemic-a-prospective-study/6EA28777DDD4C1A4EAFFE15B1CB80DD4
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Epidemiology and Psychiatric Sciences
oai:ddfv.ufv.es:10641/13552019-07-23T16:00:46Zcom_10641_132col_10641_1438
Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer.
Rynne-Vidal, Angela
Au-Yeung, Chi Lam
Jiménez-Heffernan, José A.
Pérez-Lozano, María Luisa
Cremades-Jimeno, Lucía
Bárcena, Carmen
Cristóbal García, Ignacio
Fernández-Chacón, Concepción
Yeung, Tsz Lun
C Mok, Samuel
Sandoval, Pilar
López Cabrera, Manuel
Peritoneal metastasis
Ovarian cancer
Carcinoma-associated fibroblasts
Mesothelial-to-mesenchymal transition
Ascites
Peritoneal dissemination is the primary metastatic route of ovarian cancer (OvCa), and is often accompanied
by the accumulation of ascitic fluid. The peritoneal cavity is lined by mesothelial cells (MCs), which can be
converted into carcinoma-associated fibroblasts (CAFs) through mesothelial-to-mesenchymal transition (MMT).
Here, we demonstrate that MCs isolated from ascitic fluid (AFMCs) of OvCa patients with peritoneal implants
also undergo MMT and promote subcutaneous tumour growth in mice. RNA sequencing of AFMCs revealed that
MMT-related pathways – including transforming growth factor (TGF)- signalling – are differentially regulated,
and a gene signature was verified in peritoneal implants from OvCa patients. In a mouse model, pre-induction
of MMT resulted in increased peritoneal tumour growth, whereas interfering with the TGF- receptor reduced
metastasis. MC-derived CAFs showed activation of Smad-dependent TGF- signalling, which was disrupted in OvCa
cells, despite their elevated TGF- production. Accordingly, targeting Smad-dependent signalling in the peritoneal
pre-metastatic niche in mice reduced tumour colonization, suggesting that Smad-dependent MMT could be crucial
in peritoneal carcinomatosis. Together, these results indicate that bidirectional communication between OvCa cells
and MC-derived CAFs, via TGF--mediated MMT, seems to be crucial to form a suitable metastatic niche. We
suggest MMT as a possible target for therapeutic intervention and a potential source of biomarkers for improving
OvCa diagnosis and/or prognosis.
post-print
2310 KB
2017-10-11T10:26:46Z
2017-10-11T10:26:46Z
2017
article
1096-9896
http://hdl.handle.net/10641/1355
eng
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Journal of Pathology
oai:ddfv.ufv.es:10641/31552023-11-02T11:49:27Zcom_10641_132col_10641_1435
Sodium alginate and Chitosan aided design of form-stable Polyrotaxane based phase change materials with ultra-high latent heat.
Yin, Guang-Zhong
Yang, Xiao-Mei
López, Alba Marta
Wang, Mei-Ting
Ye, Wen
Xu, Baoyun
De-Yi, Wang
Polyrotaxane
Sodium alginate
Chitosan
We prepared a series of highly porous Polyrotaxane/sodium alginate, and Polyrotaxane/Chitosan foam alloys according to a sustainable pathway by using water as the only solvent. The foam alloys were further used as supporter materials for poly (ethylene glycol) (PEG) encapsulation, to fabricate shape-stable bio-based phase change materials (PCMs). The pore morphology and the internal interface between PEG and foam alloys were characterized by scanning electron microscope (SEM). Due to the good compatibility between foam alloys and PEG, the PCM performed perfect anti-leakage properties. The introduction of sodium alginate or Chitosan ensures the shape stability of the PCMs during the phase transition. The PCMs performed good cycle stability and showed ultra-high latent heat (171.6 J g−1–189.5 J g−1). Finally, we compared the typical indicators of this work with those reported in the literature, and the comparison highlighted that the present PCMs have the significant advantages: high melting enthalpy, convenient preparation and outstanding sustainability. Notably, the work provided a sustainable idea for the design of anti-leakage and shape-stable PEG-based PCMs.
pre-print
1327 KB
2022-11-16T11:21:13Z
2022-11-16T11:21:13Z
2022
article
0141-8130
https://hdl.handle.net/10641/3155
10.1016/j.ijbiomac.2022.09.149
eng
https://www.sciencedirect.com/science/article/pii/S0141813022020803?via%3Dihub
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
International Journal of Biological Macromolecules
oai:ddfv.ufv.es:10641/3592019-07-23T15:26:33Zcom_10641_132col_10641_1423
TSPAN13 expression in ovarian cancer
Bonnin, Ana
Arencibia, José Manuel
Martín, Susana
Vidart, José Antonio
Furió, Vicente
Coronado, Pluvio
Cáncer
Vicerrectorado de Investigación UFV
2012-08-09T03:05:34Z
2012-08-09T03:05:34Z
2009-09
article
105/09
http://hdl.handle.net/10641/359
eng
Congress ESMO 34;Berlín, 2009
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
oai:ddfv.ufv.es:10641/21962021-02-04T09:24:53Zcom_10641_132col_10641_1424
Deep learning self-regulation strategies: Validation of a situational model and its questionnaire.
Panadero, Ernesto
Alonso Tapia, Jesús
García Pérez, Daniel
Fraile Ruiz, Juan
Sánchez Galán, José Manuel
Pardo, Rodrigo
Learning strategies
Goal orientation
Self-efficacy
Self-regulated learning
Assessment of learning strategies
Measuring self-regulated learning is crucial to improve our educational interventions. Self-report has been the major data collection method and a number of questionnaires exist. Importantly, the vast majority of the questionnaires are constructed from general theoretical models. Our aim was to develop a model and its questionnaire –i.e. Deep Learning Strategies questionnaire- to investigate how students regulate their learning strategies in more realistic learning situations. Four scales were created: (1) Basic learning self-regulation strategies; (2) Visual elaboration and summarizing strategies; (3) Deep information processing strategies; and (4) Social learning self-regulation strategies. A total of 601 higher education students formed the sample. We analyzed, first, the internal validity of the questionnaire. Three structural models were tested: (M1) mono-factor; (M2) scales correlate among them freely, and (M3) the scales are indicators of a general construct. The latter model showed a slight better fit. Additionally, a path analysis was carried out to study the degree in which the use of the Deep learning strategies depends on personal factors and is associated to performance. It was found that the use depends directly and positively on Learning goal orientation, on the self-messages defining the Self-regulation style of emotion and motivation focused on learning, and on Effort. Besides, these two last variables convey the effect of Self-efficacy that, at the same time, affects Effort. Academic performance depends positively on Effort but negatively to the use of Deep learning strategies. It is hypothesized this negative relationship is due to the method of measurement of academic performance.
pre-print
1467 KB
2021-01-28T09:47:56Z
2021-01-28T09:47:56Z
2021
article
1136-1034
http://hdl.handle.net/10641/2196
10.1016/j.psicod.2020.11.003
eng
https://www.sciencedirect.com/science/article/abs/pii/S1136103420300411?via%3Dihub
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Revista de Psicodidáctica
oai:ddfv.ufv.es:10641/36382024-01-04T01:00:08Zcom_10641_132col_10641_1438
Insulin and HOMA in Spanish prepubertal children: Relationship with lipid profile.
Garcés, Carmen
Cano, Beatriz
Granizo, Juan J
Benavente, Mercedes
Viturro, Enrique
Gutiérrez Guisado, Javier
De Oya, Iria
Lasunción, Miguel A
De Oya, Manuel
Insulin
HOMA
Free fatty acids
Lipid profile
Objective:
The effects of insulin or insulin resistance on the lipid profile seem to change with age. The aim of this study was to analyze insulin levels and an insulin resistance index and to investigate the relationship between these and the lipid profile in a population-based sample of Spanish prepubertal children.
Methods:
1048 (524 boys and 524 girls) randomly selected prepubertal children were studied. Children were 6 to 8 years old with a mean age of 6.7. Plasma lipid, FFA and insulin levels were measured. The homeostatic model assessment (HOMA) was calculated as an indicator of insulin resistance.
Results:
When analyzing percentile values of insulin, HOMA and FFA by sex, we observed that girls had significantly higher insulin concentrations than boys (except at the 10th percentile) and significantly higher FFA (except at the 90th percentile) with no significant differences between sexes for HOMA. Multivariate regression analyses showed that insulin was positively associated with glucose, triglycerides and apoB in boys but not in girls, and negatively associated with FFA in both genders.
Conclusions:
We report here data about the distribution of insulin in the Spanish prepubertal population. The higher levels of insulin in prepubertal girls could indicate that girls start to be more insulin resistant than boys at this age, although other manifestations of insulin resistance are not yet detectable.
pre-print
211 KB
2024-01-03T12:25:24Z
2024-01-03T12:25:24Z
2005
article
0009-9120
https://hdl.handle.net/10641/3638
10.1016/j.clinbiochem.2005.07.004
eng
https://www.sciencedirect.com/science/article/abs/pii/S0009912005001918?via%3Dihub
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Clinical Biochemistry
oai:ddfv.ufv.es:10641/18642021-02-04T09:31:44Zcom_10641_1919col_10641_1920
Belleza, forma y función en la obra de Ronan y Erwan Bouroullec.
Campos Gómez, Roberto
López Raso, Pablo
Humanidades y Ciencias Sociales
pre-print
37152 KB
2020-02-18T13:00:36Z
2020-02-18T13:00:36Z
2017
doctoralThesis
http://hdl.handle.net/10641/1864
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
oai:ddfv.ufv.es:10641/31792022-12-10T01:00:14Zcom_10641_132col_10641_1435
Assessing the Performance of Design Variations of a Thermoacoustic Stirling Engine Combining Laboratory Tests and Model Results.
Iniesta, Carmen
Olazagoitia, José Luis
Víñolas Prat, Jordi
Gros, Jaime
Thermoacoustic Stirling engine
Reactive acoustic power
Acoustic network improvement
Early-stage design
post-print
4424 KB
2022-12-09T11:45:37Z
2022-12-09T11:45:37Z
2022
article
2075-1702
https://hdl.handle.net/10641/3179
10.3390/machines10100958
eng
https://www.mdpi.com/2075-1702/10/10/958
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Machines
oai:ddfv.ufv.es:10641/32932023-03-02T01:00:10Zcom_10641_132col_10641_1438
International consensus conference recommendations on ultrasound education for undergraduate medical students.
Hoppmann, Richard A.
Villén, Tomás
Mustafa, Hassan
Objectives
The purpose of this study is to provide expert consensus recommendations to establish a global ultrasound curriculum for undergraduate medical students.
Methods
64 multi-disciplinary ultrasound experts from 16 countries, 50 multi-disciplinary ultrasound consultants, and 21 medical students and residents contributed to these recommendations. A modified Delphi consensus method was used that included a systematic literature search, evaluation of the quality of literature by the GRADE system, and the RAND appropriateness method for panel judgment and consensus decisions. The process included four in-person international discussion sessions and two rounds of online voting.
Results
A total of 332 consensus conference statements in four curricular domains were considered: (1) curricular scope (4 statements), (2) curricular rationale (10 statements), (3) curricular characteristics (14 statements), and (4) curricular content (304 statements). Of these 332 statements, 145 were recommended, 126 were strongly recommended, and 61 were not recommended. Important aspects of an undergraduate ultrasound curriculum identified include curricular integration across the basic and clinical sciences and a competency and entrustable professional activity-based model. The curriculum should form the foundation of a life-long continuum of ultrasound education that prepares students for advanced training and patient care. In addition, the curriculum should complement and support the medical school curriculum as a whole with enhanced understanding of anatomy, physiology, pathophysiological processes and clinical practice without displacing other important undergraduate learning. The content of the curriculum should be appropriate for the medical student level of training, evidence and expert opinion based, and include ongoing collaborative research and development to ensure optimum educational value and patient care.
Conclusions
The international consensus conference has provided the first comprehensive document of recommendations for a basic ultrasound curriculum. The document reflects the opinion of a diverse and representative group of international expert ultrasound practitioners, educators, and learners. These recommendations can standardize undergraduate medical student ultrasound education while serving as a basis for additional research in medical education and the application of ultrasound in clinical practice.
post-print
1979 KB
2023-03-01T12:59:19Z
2023-03-01T12:59:19Z
2022
article
2036-3176
https://hdl.handle.net/10641/3293
10.1186/s13089-022-00279-1
eng
https://theultrasoundjournal.springeropen.com/articles/10.1186/s13089-022-00279-1
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
The Ultrasound Journal
oai:ddfv.ufv.es:10641/25492023-12-15T08:15:06Zcom_10641_132col_10641_1428
Questionnaire on the Training Profile of a Learning Therapy Specialist: Creation and Validation of the Instrument.
Martín Martínez, Laura
Vela Llaurado, Esther
initial training
teachers
learning therapy
validation
questionnaire
This article provides a description of the creation and validation process for a questionnaire
designed to analyze the initial training received by students of degree programs in pre-primary and
primary education, specializing in learning therapy. The instrument consists of 175 items in three
sections: the first collects sociodemographic data; the second analyzes the initial training received;
and the third and final section analyzes the perception of this initial training. The questionnaire
was subjected to a double validation process: an evaluation by a panel of experts and a pilot group,
these permitted the validation of the content and construct, as well as the corresponding reliability
assessment. The results confirm the validity of the questionnaire with an excellent reliability index,
allowing the e ective evaluation of the training profile of learning therapy specialists.
post-print
257 KB
2021-11-02T08:34:10Z
2021-11-02T08:34:10Z
2020
article
2071-1050
http://hdl.handle.net/10641/2549
10.3390/su12219159
eng
https://www.mdpi.com/2071-1050/12/21/9159
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Sustainability
oai:ddfv.ufv.es:10641/36812024-01-12T01:00:08Zcom_10641_132col_10641_1426
Gobernanza corporativa y sostenibilidad: una aproximación legal y humanística.
Palao Uceda, Juan
El gobierno corporativo y la responsabilidad social corporativa (RSC) se han encontrado y han unido fuerzas en una promoción conjunta de la sostenibilidad y de los tres factores en los que esta se divide, los ambientales, los sociales y los de gobierno corporativo (ASG/ESG). Las últimas reformas normativas y el propio mercado exigen a las grandes corporaciones una implicación con la sostenibilidad cada vez más intensa. En este contexto, la reputación se ha consolidado como el mejor instrumento del que disponen los administradores para impulsar el crecimiento y la consolidación de las sociedades en el mercado.
pre-print
2024-01-11T09:50:10Z
2024-01-11T09:50:10Z
2022
bookPart
Gobierno corporativo, sostenibilidad y reputación.
9788411254175
https://hdl.handle.net/10641/3681
spa
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Thomson Reuters Aranzadi
oai:ddfv.ufv.es:10641/30292022-07-06T00:00:26Zcom_10641_132col_10641_1423
Grape Polyphenols to Arrest in Vitro Proliferation of Human Leukemia Cells: A Systematic Review and Meta-analysis.
García Martínez, Daniel Jesús
Calzada Funes, Javier
Martín Saborido, Carlos
Santos Tejedor, Cruz
Grape polyphenols
Leukemia
Cell proliferation
Meta-analysis
Leukemia is a heterogeneous group of hemopoietic cancers, which accounts for 2.6% of new cases per year of total cancer incidence worldwide. Grapes and grape-derived products, such as grape juice, are naturally rich in polyphenols, bioactive compounds with antioxidant properties. Certain polyphenols have been proved to alter oxidative balance, both in inducing apoptosis in cancer cells and in preventing cancer development via controlling oxidative stress. To assess the therapeutic potential of grape polyphenols in the treatment of leukemia, a systematic review and meta-analysis of the reported data on leukemia was carried out. Following the PRISMA guide, a literature review of published papers on leukemia and polyphenols from the last 50 years was conducted, and 17 scientific articles published from 2002 to 2017 were included in the study. Resveratrol 50 μM had the highest growth inhibition effect (67%) followed by quercetin (30%). The results also point to a differential effect of polyphenols based on cell lineage; monocytes- and myelocytic-derived cell lines are the most susceptible, with a mean of 85% and 64% proliferation inhibition, respectively. Moreover, results show that growth inhibition cannot be associated with a molecular effect of polyphenols on the cell cycle arrest.
pre-print
303 KB
2022-07-05T10:53:44Z
2022-07-05T10:53:44Z
2022
article
1525-6103
http://hdl.handle.net/10641/3029
10.1080/87559129.2020.1810700
eng
https://www.tandfonline.com/doi/abs/10.1080/87559129.2020.1810700?journalCode=lfri20
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Food Reviews International
oai:ddfv.ufv.es:10641/6292019-07-23T16:22:12Zcom_10641_252col_10641_1444
El informe del coronel Serrano sobre la expedición militar a Ponape de 1890
Togores, Luis Eugenio
España-Colonias-Filipinas
Pacífico (Región)-Colonización
post-print
1,08 MB
2013-03-08T04:47:29Z
2013-03-08T04:47:29Z
1995
article
1134-7627
http://hdl.handle.net/10641/629
spa
Mar Océana, Nº 02
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Asociación Francisco López de Gómara
oai:ddfv.ufv.es:10641/36522024-02-28T11:32:18Zcom_10641_132col_10641_1438
Outcomes of an enhanced recovery after radical cystectomy program in a prospective multicenter study: compliance and key components for success.
Llorente, C.
Guijarro, A.
Hernández, V.
Fernández-Conejo, G.
Llanes González, Luis
García Del Valle, S.
Bladder cancer
ERAS
Radical cystectomy
Urothelial cancer
Objective: To investigate the effect of an Enhanced Recovery After Surgery (ERAS) program on complications and length of stay (LOS) after radical cystectomy (RC) and to assess if the number and type of components of ERAS play a key role on the decrease of surgical morbidity.
Materials and methods: We analyzed the data of 277 patients prospectively recruited in 11 hospitals undergoing RC initially managed according to local practice (Group I) and later within an ERAS program (Group II). Two main outcomes were defined: 90-day complications rate and LOS. As secondary variables we studied 90-day mortality, 30-day readmission and transfusion rate.
Results: Patients in Group II had a higher use of ERAS measures (98.6%) than those in Group I (78.2%) (p < 0.05). Patients in Groups I and II experienced similar complications (70.5% vs. 66%, p = 0.42). LOS was not different between Groups I and II (12.5 and 14 days, respectively, p = 0.59). The risk of having any complication decreases for patients having more than 15 ERAS measures adopted [RR = 0.815; 95% confidence interval (CI) 0.667-0.996; p = 0.045]. Avoidance of transfusion and nasogastric tube, prevention of ileus, early ambulation and a fast uptake of a regular diet are independently associated with the absence of complications.
Conclusions: Complications and LOS after RC were not modified by the introduction of an ERAS program. We hypothesize that at least 15 measures should be applied to maximize the benefit of ERAS.
pre-print
1,27 MB
2024-01-05T12:02:31Z
2024-01-05T12:02:31Z
2020
article
1433-8726
https://hdl.handle.net/10641/3652
10.1007/s00345-020-03132-z
eng
https://link.springer.com/article/10.1007/s00345-020-03132-z
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
closedAccess
World Journal of Urology
oai:ddfv.ufv.es:10641/25402021-10-29T00:00:32Zcom_10641_132col_10641_1423
Teaching chemical engineering to biotechnology students in the time of COVID-19: Assessment of the adaptation to digitalization.
Ripoll Morales, Vanessa
Godino Ojer, Marina
Calzada Funes, Javier
Biochemical engineering
COVID-19
Emergency remote teaching
Higher-order thinking skills
Collaborative learning
Diversity outreach
With the global outbreak of COVID-19 in March 2020, there was an immediate shutdown of face-to-face classes and a sudden shift to on-line learning. Confinement required finding innovative approaches to teaching and student assessment. This paper aims to share the experience of adapting the course in Biochemical Engineering, part of the Biotechnology program at Francisco de Vitoria University (Madrid, Spain), to remote learning.
A sequence of collaborative learning activities, with active student participation, was designed to replace the traditional mid-term exam. Activities were carefully implemented, considering the range of learning styles. Engineering skills, transversal competences and higher-order thinking skills were fostered through these activities.
The analysis of the teaching/learning experience was based on teacher observations, academic performance and student surveys. All indicators showed that the adopted methodology had a positive impact of student performance. Student participation, especially among those repeating the course, also improved. Furthermore, students gained a more accurate and positive perception of the link between Chemical Engineering and Biotechnology, which may have a favourable impact on the teaching of Bioreactors in the coming academic year.
pre-print
846 KB
2021-10-28T10:58:32Z
2021-10-28T10:58:32Z
2021
article
1749-7728
http://hdl.handle.net/10641/2540
10.1016/j.ece.2020.11.001
eng
https://www.sciencedirect.com/science/article/pii/S174977282030052X
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Education for Chemical Engineers
oai:ddfv.ufv.es:10641/22952021-04-22T00:00:19Zcom_10641_132col_10641_1438
Análisis del valor predictivo de los criterios de aislamiento preventivo en una unidad de cuidados intensivos.
Abella Álvarez, A.
Janeiro Lumbreras, D.
Lobo Valbuena, Beatriz
Naharro Abellán, A.
Torrejón Pérez, Inés
Enciso Calderón, V.
Varillas Delgado, David
Conejo Márquez, I.
García Manzanedo, S.
López de la Oliva Calvo, L.
García Arias, María
Gordo Vidal, Federico
Pre-emptive isolation
Antimicrobial resistance
Multidrug-resistant bacteria
Intensive Care Unit
Objetivo: evaluar la precisión diagnóstica de los criterios empleados para detectar el paciente realmente portador de microrganismos multi-resistentes (MMR)
Diseño: Estudio prospectivo, observacional de mayo 2014 a mayo 2015
Ámbito: Unidad de Cuidados Intensivos polivalente.
Pacientes cohorte de pacientes ingresados de forma consecutiva que cumplían los siguientes criterios de aislamiento preventivo: hospitalización de más de 4 días en los últimos 3 meses (“hospital”); antibioterapia durante una semana en el último mes (“antibiótico”), pacientes institucionalizados o en contacto con cuidados sanitarios (“institución o cuidado”); portador de MMR los últimos 6 meses (“MMR previo”).
Variables: edad, sexo, Simplified Acute Physiology Score 3, tipo de paciente (médico vs quirúrgico), estancia en UCI, mortalidad en UCI, mortalidad hospitalaria y tiempo de aislamiento. Se realizó un análisis multivariable con regresión logística múltiple entre cada uno de los factores de riesgo y el que el paciente fuera realmente portador de MMR.
Resultados: Durante el periodo de estudio ingresaron 575 pacientes y cumplieron los criterios un 28%. De los 162 pacientes con criterios 51 (31%) eran portadores de MMR y de los que no cumplían criterios 29 (7%) sí que tenían portadores. En el análisis multivariable la única variables asociada de forma independiente con el ser portador fue “MMR previo” con una OR 12.14 (IC 95% 4.24 - 34.77)
Conclusiones El único criterio que se asoció de forma independiente con la capacidad de detectar los pacientes con MMR al ingreso en la UCI fue haber presentado un “MMR previo”
pre-print
229 KB
2021-04-21T12:33:27Z
2021-04-21T12:33:27Z
2021
article
0210-5691
http://hdl.handle.net/10641/2295
10.1016/j.medin.2019.09.022
spa
https://www.medintensiva.org/es-analisis-del-valor-predictivo-criterios-articulo-S0210569119302451
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Medicina intensiva
oai:ddfv.ufv.es:10641/6952019-07-23T16:21:55Zcom_10641_252col_10641_1444
Quinto Centenario del nacimiento de Carlos I
Hernández Sánchez-Barba, Mario
Carlos I, Rey de España
España-Historia-1517-1556, Carlos I
América-Descubrimiento y exploración
post-print
384,43 KB
2013-04-01T05:05:33Z
2013-04-01T05:05:33Z
2000
article
1134-7627
http://hdl.handle.net/10641/695
spa
Mar Océana, Nº 05
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Asociación Francisco López de Gómara
Centro Universitario Francisco de Vitoria
oai:ddfv.ufv.es:10641/25752023-11-02T12:31:17Zcom_10641_132col_10641_1424
Effects of Ibuprofen Use on Lymphocyte Count and Oxidative Stress in Elite Paralympic Powerlifting.
Aidar, Felipe J.
Fraga, Guacira S.
Getirana-Mota, Márcio
Marçal, Anderson Carlos
Santos, Jymmys L.
de Souza, Raphael Fabricio
Pires Ferreira, Alexandre Reis
Borba Neves, Eduardo
de Freitas Zanona, Aristela
Bulhões-Correia, Alexandre
Merino Fernández, María
Paralympic Powerlifting
Ibuprofen
Muscle strength
Oxidative stress
Recovery of function
Background: Paralympic Powerlifting (PP) training tends to promote fatigue and oxidative stress. Objective: To analyze the effects of ibuprofen use on performance and oxidative stress in post-training PP athletes. Methodology: Ten national level PP athletes (age: 27.13 ± 5.57) were analyzed for oxidative stress in post-training. The study was carried out in three weeks, (1) familiarization and (2 and 3) evaluated the recovery with the use of a placebo (PLA) and ibuprofen (IBU), 800 mg. The Peak Torque (PT), Torque Development Rate (TDR), Fatigue Index (FI), reactive substances to thiobarbituric acid (TBARS) and sulfhydryl groups (SH) were evaluated. The training consisted of five sets of five repetitions (80–90%) 1-Repetition Maximum (1-RM) in the bench press. Results: The IBU showed a higher PT (24 and 48 h, p = 0.04, ɳ2 p = 0.39), a lower FI (24 h, p = 0.01, ɳ2p = 0.74) and an increased lymphocyte count (p < 0.001; ɳ2p = 4.36). There was no change in oxidative stress. Conclusions: The use of IBU provided improvements in strength and did not protect against oxidative stress
post-print
915 KB
2021-11-04T10:42:17Z
2021-11-04T10:42:17Z
2021
article
2079-7737
http://hdl.handle.net/10641/2575
10.3390/biology10100986
eng
https://www.mdpi.com/2079-7737/10/10/986
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Biology
oai:ddfv.ufv.es:10641/40162024-02-16T01:00:14Zcom_10641_132col_10641_1438
Tuberculosis in Spain: An opinion paper
Moreno Guillén, Santiago
Rodríguez-Artalejo, Fernando
Ruiz-Galiana, Julián
Martín Delgado, María Cruz
Bouza, Emilio
Tuberculosis
Diagnosis
Extrapulmonary tuberculosis
Latent tuberculosis
Pediatric tuberculosis
Populations at risk
Intensive Care Unit
This document is the result of the deliberations of the Committee on Emerging Pathogens and COVID-19 of the Illustrious Official College of Physicians of Madrid (ICOMEM) regarding the current situation of tuberculosis, particularly in Spain. We have reviewed aspects such as the evolution of its incidence, the populations currently most exposed and the health care circuits for the care of these patients in Spain. We have also discussed latent tuberculosis, the reality of extrapulmonary disease in the XXI century and the means available in daily practice for the diagnosis of both latent and active forms. The contribution of molecular biology, which has changed the perspective of this disease, was another topic of discussion. The paper tries to put into perspective both the classical drugs and their resistance figures and the availability and indications of the new ones. In addition, the reality of direct observation in the administration of antituberculosis drugs has been discussed. All this revolution is making it possible to shorten the treatment time for tuberculosis, a subject that has also been reviewed. If everything is done well, the risk of relapse of tuberculosis is small but it exists. On the other hand, many special situations have been discussed in this paper, such as tuberculosis in pediatric age and tuberculosis as a cause for concern in surgery and intensive care. The status of the BCG vaccine and its present indications as well as the future of new vaccines to achieve the old dream of eradicating this disease have been discussed. Finally, the ethical and medicolegal implications of this disease are not a minor issue and our situation in this regard has been reviewed.
post-print
367 KB
2024-02-15T12:17:06Z
2024-02-15T12:17:06Z
2023
article
1988-9518
https://hdl.handle.net/10641/4016
10.37201/req/115.2023
eng
https://seq.es/abstract/rev-esp-quimioter-2023-november-2-2/
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Revista Española de Quimioterapia
oai:ddfv.ufv.es:10641/28862022-03-05T01:01:11Zcom_10641_132col_10641_1438
The hippocampus as the switchboard between perception and memory.
Tredera, Matthias S.
Charest, Ian
Michelmann, Sebastian
Martín-Buro, María Carmen
Roux, Frederic
Carceller-Benito, Fernando
Ugalde-Canitrot, Arturo
Rollings, David T.
Sawlani, Vijay
Chelvarajah, Ramesh
Wimber, Maria
Hanslmayr, Simon
Staresina, Bernhard P.
Adaptive memory recall requires a rapid and flexible switch
from external perceptual reminders to internal mnemonic representations.
However, owing to the limited temporal or spatial
resolution of brain imaging modalities used in isolation, the
hippocampal–cortical dynamics supporting this process remain
unknown. We thus employed an object-scene cued recall paradigm
across two studies, including intracranial electroencephalography
(iEEG) and high-density scalp EEG. First, a sustained increase in hippocampal
high gamma power (55 to 110 Hz) emerged 500 ms after
cue onset and distinguished successful vs. unsuccessful recall. This
increase in gamma power for successful recall was followed by a
decrease in hippocampal alpha power (8 to 12 Hz). Intriguingly,
the hippocampal gamma power increase marked the moment at
which extrahippocampal activation patterns shifted from perceptual
cue toward mnemonic target representations. In parallel,
source-localized EEG alpha power revealed that the recall signal
progresses from hippocampus to posterior parietal cortex and
then to medial prefrontal cortex. Together, these results identify
the hippocampus as the switchboard between perception and
memory and elucidate the ensuing hippocampal–cortical dynamics
supporting the recall process.
post-print
1844 KB
2022-03-04T12:27:58Z
2022-03-04T12:27:58Z
2021
article
0027-8424
http://hdl.handle.net/10641/2886
10.1073/pnas.2114171118
eng
https://www.pnas.org/doi/10.1073/pnas.2114171118
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Proceedings of the National Academy of Sciences (PNAS)
oai:ddfv.ufv.es:10641/6272019-07-23T16:26:25Zcom_10641_252col_10641_1444
Crónica Iberoamericana
Valcárcel Arribas, Rafael
América latina-Integración política
América latina-Integración económica
Unión Europea-Relaciones-América latina
post-print
1,21 MB
2013-03-05T09:47:53Z
2013-03-05T09:47:53Z
1995
article
1134-7627
http://hdl.handle.net/10641/627
spa
Mar Océana, Nº 02
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Asociación Francisco López de Gómara
oai:ddfv.ufv.es:10641/5112019-07-23T16:17:38Zcom_10641_252col_10641_1444
El decenio de Naciones Unidas para el avance de las mujeres (1975-1985)
Giménez Armentia, Pilar
Mujeres-Situación social
Igualdad de oportunidades
Naciones Unidas
Organismos Internacionales
post-print
159,74 KB
2013-02-06T04:37:45Z
2013-02-06T04:37:45Z
2007
article
1134-7627
http://hdl.handle.net/10641/511
spa
Mar Océana, Nº 21
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Universidad Francisco de Vitoria
Foro Hispanoamericano Francisco de Vitoria
oai:ddfv.ufv.es:10641/37942024-02-28T12:25:46Zcom_10641_132col_10641_1438
Identification of TNF-alpha and MMP-9 as potential baseline predictive serum markers of sunitinib activity in patients with renal cell carcinoma using a human cytokine array.
Pérez-Gracia, J. L.
Prior, C.
Guillén-Grima, F.
Segura, V.
González, A.
Panizo, A.
Melero, I.
Grande-Pulido, E.
Gurpide, A.
Gurpide, A.
Gil-Bazo, I.
Calvo, A.
Sunitinib
Renal cell carcinoma
TNF-a
MMP-9
Selection of extreme phenotypes
BACKGROUND: Several drugs are available to treat metastatic renal-cell carcinoma (MRCC), and predictive markers to identify the most
adequate treatment for each patient are needed. Our objective was to identify potential predictive markers of sunitinib activity in
MRCC.
METHODS: We collected sequential serum samples from 31 patients treated with sunitinib. Sera of six patients with extreme
phenotypes of either marked responses or clear progressions were analysed with a Human Cytokine Array which evaluates 174
cytokines before and after treatment. Variations in cytokine signal intensity were compared between both groups and the most
relevant cytokines were assessed by ELISA in all the patients.
RESULTS: Twenty-seven of the 174 cytokines varied significantly between both groups. Five of them (TNF-a, MMP-9, ICAM-1, BDNF
and SDF-1) were assessed by ELISA in 21 evaluable patients. TNF-a and MMP-9 baseline levels were significantly increased in nonresponders and significantly associated with reduced overall survival and time-to-progression, respectively. The area under the ROC
curves for TNF-a and MMP-9 as predictive markers of sunitinib activity were 0.83 and 0.77.
CONCLUSION: Baseline levels of TNF-a and MMP-9 warrant further study as predictive markers of sunitinib activity in MRCC. Selection
of patients with extreme phenotypes seems a valid method to identify potential predictive factors of response.
pre-print
653 KB
2024-01-23T11:27:12Z
2024-01-23T11:27:12Z
2009
article
1532-1827
https://hdl.handle.net/10641/3794
10.1038/sj.bjc.6605409
eng
https://www.nature.com/articles/6605409
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
closedAccess
British Journal of Cancer
oai:ddfv.ufv.es:10641/17902021-02-04T09:24:42Zcom_10641_132col_10641_1438
CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2N141I neurons.
Ortiz Virumbrales, Maitane
Moreno, César L.
Kruglikov, Ilya
Marazuela, Paula
Sproul, Andrew
Jacob, Samson
Zimmer, Matthew
Paull, Daniel
Zhang, Bin
Schadt, Eric E.
Ehrlich, Michelle E.
Tanzi, Rudolph E.
Arancio, Ottavio
Noggle, Scott
Gandy, Sam
Alzheimer’s disease
Electrophysiology
Basal forebrain
Cholinergic
Presenilin
Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to be affected in all forms
of AD, and their dysfunction is clinically correlated with impaired short-term memory formation and retrieval. We
present an optimized in vitro protocol to generate human BFCNs from iPSCs, using cell lines from presenilin 2
(PSEN2) mutation carriers and controls. As expected, cell lines harboring the PSEN2N141I mutation displayed an
increase in the Aβ42/40 in iPSC-derived BFCNs. Neurons derived from PSEN2N141I lines generated fewer maximum
number of spikes in response to a square depolarizing current injection. The height of the first action potential at
rheobase current injection was also significantly decreased in PSEN2N141I BFCNs. CRISPR/Cas9 correction of the
PSEN2 point mutation abolished the electrophysiological deficit, restoring both the maximal number of spikes and
spike height to the levels recorded in controls. Increased Aβ42/40 was also normalized following CRISPR/Casmediated
correction of the PSEN2N141I mutation. The genome editing data confirms the robust consistency of
mutation-related changes in Aβ42/40 ratio while also showing a PSEN2-mutation-related alteration in
electrophysiology.
post-print
6813 KB
2020-01-15T11:45:54Z
2020-01-15T11:45:54Z
2017
article
2051-5960
http://hdl.handle.net/10641/1790
10.1186/s40478-017-0475-z
eng
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-017-0475-z
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
openAccess
Acta Neuropathologica Communications
oai_dc////100