Altered Functional Connectivity in Essential Tremor. A Resting-State fMRI Study.

Repositorio Dspace/Manakin

Altered Functional Connectivity in Essential Tremor. A Resting-State fMRI Study.

Mostrar el registro completo del ítem

Título: Altered Functional Connectivity in Essential Tremor. A Resting-State fMRI Study.
Autor: Benito-León, Julián; Louis, Elan D.; Romero Muñoz, Juan Pablo; Hernández-Tamames, Juan Antonio; Manzanedo, Eva; Álvarez-Linera, Juan; Bermejo-Pareja, Félix; Posada, Ignacio; Rocon, Eduardo
Resumen: Essential tremor (ET) has been associated with a spectrum of clinical features, with both motor and nonmotor elements, including cognitive deficits. We employed resting-state functional magnetic resonance imaging (fMRI) to assess whether brain networks that might be involved in the pathogenesis of nonmotor manifestations associated with ET are altered, and the relationship between abnormal connectivity and ET severity and neuropsychological function. Resting-state fMRI data in 23 ET patients (12 women and 11 men) and 22 healthy controls (HC) (12 women and 10 men) were analyzed using independent component analysis, in combination with a ‘‘dualregression’’ technique, to identify the group differences of resting-state networks (RSNs) (default mode network [DMN] and executive, frontoparietal, sensorimotor, cerebellar, auditory/language, and visual networks). All participants underwent a neuropsychological and neuroimaging session, where resting-state data were collected. Relative to HC, ET patients showed increased connectivity in RSNs involved in cognitive processes (DMN and frontoparietal networks) and decreased connectivity in the cerebellum and visual networks. Changes in network integrity were associated not only with ET severity (DMN) and ET duration (DMN and left frontoparietal network), but also with cognitive ability.Moreover, in at least 3 networks (DMN and frontoparietal networks), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, verbal memory, visual memory, and language) and depressive symptoms. Further, in the visual network, decreased connectivity was associated with worse performance on visuospatial ability. ET was associated with abnormal brain connectivity in major RSNs that might be involved in both motor and nonmotor symptoms. Our findings underscore the importance of examining RSNs in this population as a biomarker of disease.
Identificador universal: http://hdl.handle.net/10641/1193
Fecha: 2015


Ficheros en el ítem

Ficheros Tamaño Formato Ver
Altered_Functional_Connectivity_in_Essential 5.pdf 625.3Kb PDF Ver/Abrir

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro completo del ítem

Atribución-NoComercial-SinDerivadas 3.0 España Excepto si se señala otra cosa, la licencia del ítem se describe comoAtribución-NoComercial-SinDerivadas 3.0 España

Buscar en DSpace


Búsqueda avanzada

Listar

Mi cuenta

Estadísticas

Enlaces